Fios Genomics’ Post

When I started my scientific career microarrays were all the rage - "so much data"; "game changer" etc etc. Then sequencing came along and it added the problems of computational power, storage capacity etc. In recent years we've now gone to the resolution of sequencing the transcriptome of a single cell with sometimes tens of thousands of cells in a single experiment. "What can we do to make this even more complex?". "Lets add a spatial component to compound all the issues!". If dealing with spatial or single cell data and the complexities around computational resource and how to interpret results has tipped you over the edge - get in touch!

A little clip of Dr. April Kloxin's presentation, "Harnessing Advanced Cell Culture Models for Drug Discovery Breakthroughs". Check out how #RASTRUM 3D cell models have expedited her workflow! 🎥 Missed the webinar? Watch the recording here: https://lnkd.in/gt_KPqeE #3DBiology #3DCellCulture #DrugDiscovery #InnovationInBiology #InventiaInsights #Biotech #CellBiology #LifeSciences

Today, we dive into #bioinformatics and the crucial role it plays in our holistic multi-omics approach, to help you make more informed decisions and to streamline your drug development process. 👨💻🌐 Stay tuned for upcoming posts where we'll explore this powerful toolset in more detail. For more information on the extensive services our bioinformaticians provide, visit our dedicated webpage : https://lnkd.in/dRAzH_rb #Bioinformatics #MultiOmics #Omics #DrugDevelopment #BiomarkerDiscovery

🔍Very interesting article in the September edition of GEN (Genetic Engineering & Biotechnology News, pages 22-24) comparing scale-out vs. scale-up: https://lnkd.in/eEUUQkHD For RNA production, scaling out provides key advantages: 🤸♂️ Flexibility in production scale ✨ Ease of operation 💰 CAPEX savings 🚀 Improved production performance   At Quantoom Biosciences, our RNA production operates in a repeat batch mode: 20mL IVT. All IVT reactions in Ntensify™ midi perform uniformly and with minimized shear forces. Plus, purchasing disposables in bulk helps reduce costs, as they are suitable across all production scales. By choosing scale-out, RNA production is efficient, adaptable, and cost-effective! #RNA #ScaleOut #Ntensify

A little snippet of Dr. April Kloxin's talk "Harnessing Advanced Cell Culture Models for Drug Discovery Breakthroughs" where she gives us a great overview of how #RASTRUM 3D cell models have enhanced her workflow.

Don't miss Janet Piñero, our Head of Bioinformatics, presenting at BioTechX! You may already be familiar with DISGENET, but have you seen the brand new platform? DISGENET simplifies gene-disease research by integrating scattered data from diverse data sources, such as databases scientific literature, and clinical trials, into a single resource. Join Janet on Wednesday, October 9th at 5:05 PM in Theatre 3 to learn about DISGENET's new features and its potential to accelerate drug discovery and precision medicine. Visit us at booth 620 or send a meeting request. We'd love to connect with you during the conference! #BioTechX #Pharma #Biotech #Bioinformatics #Genomics #PrecisionMedicine #DISGENET #DataForTomorrowsHealth

"Make or break questions for a drug discovery project often come down to, “does modulating this target do what we want?” and, “what else does modulating this target do?” In order to answer those questions quickly and make drug discovery decisions with confidence, an understanding of target engagement and corresponding on- and off-target effects on biology is critical. " https://lnkd.in/g3W2gTN5 #drugdiscovery #drugdelivery #decisiontools

Exciting news from SBH Sciences! 💡 We're excited to share our updated company presentation, showcasing how SBH Sciences has assisted over 350 biotech companies globally over the last 27 years. Highlights include: ✅ Bringing 7 NCE's to clinical trials ✅ Comprehensive Cell-Based Products ✅ Advanced Bioanalytical Services ✅ Expert Cell Culture Services ✅ Specialized Protein Purification Services ✅ Valuable data insights Discover more about our products and services here: https://lnkd.in/eTmnyYjy #companypresentation #contractresearchorganizaton #biotech #natick #diagnostics

Beyond Viability: Advancing CHO Cell Culture Process Strategies to Modulate Host Cell Protein Levels While purification strategies usually offer substantial HCP clearance, certain problematic HCPs, particularly lipases, pose significant challenges. This study investigates the accumulation of various problematic HCPs in CHO cell culture using transcriptomics, revealing correlations between cell culture parameters and HCP activity. Contrary to conventional assumptions, viability alone does not reliably predict HCP levels, with factors such as clone selection, host cell line choice, and media feed type significantly influencing HCP accumulation. Leveraging transcriptomics-based approaches, we demonstrate the potential of upstream process control strategies to mitigate HCP presence and improve biologic product quality. Our findings underscore the importance of considering diverse cell culture parameters in bioprocess optimization to ensure product stability and quality. https://lnkd.in/g27Z3pc3 #aspenalert #biotech #bioprocess