Corey Stay AdapTatum’s Post

Accelerating Cell Culture Media Development Using Bayesian Optimization-Based Iterative Experimental Design Here, we have applied a Bayesian Optimization-based iterative framework for experimental design to accelerate cell culture media development for two applications. First, we show this approach yields new compositions of media with cytokine supplementation to maintain the viability and distribution of PBMCs in culture. Second, we applied this framework to optimize the production of three recombinant proteins in K.phaffii cultivations. For both applications, we identified conditions with improved outcomes compared to the initial standard media using 3 to 30 times fewer experiments than other methods such as the Design of Experiments. Subsequently, we also demonstrated the extensibility of our approach to efficiently account for additional design factors through transfer learning. https://lnkd.in/g9c_7ZxK #aspenalert #biotech #bioprocess

Did you know that RNA circularization could unlock new therapeutic possibilities? We’re excited to see Abogen Biotech’s latest findings published in Nucleic Acids Research! 🚀Their innovative approach to RNA circularization utilized our EasyAna dsRNA, FlysisAmp Cells-to-CT products, and HiScript III. This research could pave the way for advanced circRNA therapies. 👉 Interested in the details? Scan the QR code to read the complete study! #LifeSciences #Biotech #CircRNA #Research

🔍Very interesting article in the September edition of GEN (Genetic Engineering & Biotechnology News, pages 22-24) comparing scale-out vs. scale-up: https://lnkd.in/eEUUQkHD For RNA production, scaling out provides key advantages: 🤸♂️ Flexibility in production scale ✨ Ease of operation 💰 CAPEX savings 🚀 Improved production performance   At Quantoom Biosciences, our RNA production operates in a repeat batch mode: 20mL IVT. All IVT reactions in Ntensify™ midi perform uniformly and with minimized shear forces. Plus, purchasing disposables in bulk helps reduce costs, as they are suitable across all production scales. By choosing scale-out, RNA production is efficient, adaptable, and cost-effective! #RNA #ScaleOut #Ntensify

📢 Revolutionizing Bioeconomy: Boosting Protein Synthesis 💡 Ribosome pool engineering can increase protein synthesis yields, lowering drug manufacturing costs and transforming the bioeconomy. 💊🌱🧬 Researchers from Northwestern University and Stanford University studied the effect of ribosomal RNA operon sequences on protein synthesis in Escherichia coli. They found that differences in ribosomal sequences led to functional changes in protein production. By manipulating ribosome sequences, biomanufacturing strains can improve protein synthesis yields. 🧫🔬🚀 #BioprocessUpdates #ribosomepoolengineering #bioeconomy #proteinsynthesis #drugmanufacturing #biomanufacturing #ribosomalRNA #Escherichiacoli #proteinproduction #research #NorthwesternUniversity #StanfordUniversity #biotechnology #scientificstudy #innovation #biomanufacturingstrains ▷ Read the full article here: 📎 https://lnkd.in/eKjavmzs

Checkout the PolyJet™ In Vitro DNA Transfection Reagent by SignaGen Laboratories — available now at 43% OFF during out Black Friday Sale! Formulated with proprietary polymer synthesis technology for efficient and reproducible transfection in mammalian cells. 🐸🧬🔬 LEARN MORE: https://hubs.li/Q02ZPJmD0 The PolyJet™ reagent ensures rapid and complete degradation after endocytosis, minimizing cytotoxicity. It offers high titers of virus production and is suitable for both single and multi-DNA transfection. Explore its broad transfection spectrum today! 🌟 SHOP SALE: https://hubs.li/Q02ZPHNf0 VIEW FLYER: https://hubs.li/Q02ZPJt80 📆 Sale Ends: November 29th, 2024 #PolyJet #DNAtransfection #Biotechnology #MammalianCells #Science #Research #CellCulture #Genetics #TransfectionEfficiency #LabLife #Innovation #FroggaBio #Biodegradable #RecombinantProtein #STEM #PolymerSynthesis #TransfectionProtocol #CellBiology #LifeSciences #LabResearch #PolyJetReagent #SignaGen #LabTech #TransfectionReagent #ScientificDiscovery #Bioengineering #CellularResearch

Lipid Nanoparticles (LNPs) are transforming the landscape of CRISPR delivery systems, offering a powerful alternative to electroporation and lipo transfection. In our latest blog post, we dive into why LNPs are emerging as a preferred choice of delivery for CRISPR-based therapy development. 🔗 Learn more: https://lnkd.in/eAV2UVEy #CRISPR #GeneEditing #LipidNanoparticles #Biotechnology #TherapyDevelopment #GeneticEngineering #InnovativeMedicine #HealthcareTech

Checkout the PolyJet™ In Vitro DNA Transfection Reagent by SignaGen Laboratories — available now at FroggaBio! Formulated with proprietary polymer synthesis technology for efficient and reproducible transfection in mammalian cells. 🐸🧬🔬 LEARN MORE: https://hubs.li/Q02PKZLN0 The PolyJet™ reagent ensures rapid and complete degradation after endocytosis, minimizing cytotoxicity. It offers high titers of virus production and is suitable for both single and multi-DNA transfection. Explore its broad transfection spectrum today! 🌟 #PolyJet #DNAtransfection #Biotechnology #MammalianCells #Science #Research #CellCulture #Genetics #TransfectionEfficiency #LabLife #Innovation #FroggaBio #Biodegradable #RecombinantProtein #STEM #PolymerSynthesis #TransfectionProtocol #CellBiology #LifeSciences #LabResearch #PolyJetReagent #SignaGen #LabTech #TransfectionReagent #ScientificDiscovery #Bioengineering #CellularResearch

Beyond Viability: Advancing CHO Cell Culture Process Strategies to Modulate Host Cell Protein Levels While purification strategies usually offer substantial HCP clearance, certain problematic HCPs, particularly lipases, pose significant challenges. This study investigates the accumulation of various problematic HCPs in CHO cell culture using transcriptomics, revealing correlations between cell culture parameters and HCP activity. Contrary to conventional assumptions, viability alone does not reliably predict HCP levels, with factors such as clone selection, host cell line choice, and media feed type significantly influencing HCP accumulation. Leveraging transcriptomics-based approaches, we demonstrate the potential of upstream process control strategies to mitigate HCP presence and improve biologic product quality. Our findings underscore the importance of considering diverse cell culture parameters in bioprocess optimization to ensure product stability and quality. https://lnkd.in/g27Z3pc3 #aspenalert #biotech #bioprocess

Synthetic Biology Market worth $35.7 billion by 2027 Download PDF Brochure: https://lnkd.in/dYRNscVS The size of global #syntheticbiology market in terms of revenue was estimated to be worth $11.4 billion in 2022 and is poised to reach $35.7 billion by 2027, growing at a CAGR of 25.6% 𝐓𝐡𝐞 𝐜𝐨𝐦𝐩𝐚𝐧𝐢𝐞𝐬 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐝 𝐢𝐧 𝐭𝐡𝐢𝐬 𝐫𝐞𝐩𝐨𝐫𝐭 𝐢𝐧𝐜𝐥𝐮𝐝𝐞 Thermo Fisher Scientific, Merck Group Agilent Technologies Novozymes Ginkgo Bioworks, Inc. Amyris Precigen, GenScript Twist Bioscience Synthetic Genomics Vaccines Inc Codexis, Inc. Synthego Corporation Creative Enzymes Eurofins Scientific Finland Oy 𝐎𝐭𝐡𝐞𝐫 𝐜𝐨𝐦𝐩𝐚𝐧𝐢𝐞𝐬 𝐭𝐡𝐚𝐭 𝐚𝐫𝐞 𝐨𝐩𝐞𝐫𝐚𝐭𝐢𝐧𝐠 𝐢𝐧 𝐭𝐡𝐢𝐬 𝐦𝐚𝐫𝐤𝐞𝐭 𝐠𝐥𝐨𝐛𝐚𝐥𝐥𝐲 Arzeda bluebird bio Cellectis Zymergen Synthego Corporation Intrexon Corporation DNA Script Arbor Biotechnologies CRISPR Therapeutics Evolva Synthetic Biology Australasia Benchling Beam Therapeutics Joyn Bio Aether Eligo Bioscience Arcturus Therapeutics Inscripta, Inc. Moderna PlasmidFactory GmbH - The Minicircle Company Locus Biosciences, Inc. EnzymeWorks, Inc. Aptamer Group Leaf Expression Systems Oxford Biomedica Editas Medicine #syntheticbiology #synbio #biotechnology #geneticengineering #bioinnovation

It could cure the incurable, revolutionize vaccines and immortalize cells: RNA explained. As Tom Cech reveals in his new book “The Catalyst: RNA and the Quest to Unlock Life’s Deepest Secrets,” RNA (ribonucleic acid) is having its moment, with research surging globally and more than 400 RNA-based drugs in development. Read: https://lnkd.in/exKT9KDB #sciencesdelavie #biotechnology #biotechnology #innovation #innovations #research #sciences #medicaments #research #drugresearch #laboratories #labs #chemistry #chemistry #biology #biologie #biopharma #rna #rnatherapeutics #arn #revolution #happy