This document discusses operating Apache Flink on Apache Mesos at scale. It provides an overview of Mesos and its two-level scheduling architecture. It then discusses why Flink and Mesos are well-suited to each other, and how the Flink Mesos integration works. Finally, it covers best practices for operating Flink on Mesos at scale, including containerization, resource allocation, multi-tenancy, configuration changes, and high availability.