This document discusses considerations for large-scale SharePoint deployments on SQL Server. It provides examples of real-world deployments handling over 10TB of content. It covers understanding SharePoint databases, SQL performance tuning, and architectural design best practices. These include separating databases onto unique volumes, optimizing TempDB, maintaining around 100GB per content database, and using RAID 10 for performance. Statistical results are presented from deployments handling over 70 million documents loaded in under 12 days with expected performance.