SharePoint Syntex can help organize unstructured files like documents, audio, and video using machine learning. It can classify content, extract key details, and group related items to unlock organizational knowledge. Some practical uses include extracting address and tax information from invoices, tracking timesheets for contract workers, processing digital forms for open enrollment, and managing expiring contracts and statements of work. The system requires only a few positive examples for training and can then automate tasks using Power Apps or other tools.