RISC and CISC architectures take different approaches to processing instructions. CISC uses complex, multi-step instructions that operate directly on memory, requiring less code but more processing time per instruction. RISC breaks instructions into simple, single-clock operations that emphasize registers, requiring more code but allowing for faster, more consistent execution through pipelining. While CISC aims to minimize instructions, RISC aims to minimize processing time per instruction through simplified hardware and software.