WuXi Discovery Services’ Post

🔬 Virtual Screening: The Future of Drug Discovery Virtual screening is a cutting-edge in silico approach for modeling molecular interactions in target and lead discovery processes. It provides valuable data on ligand-target binding, offering key insights into the mechanisms of biomolecules involved in various diseases. Docking can be performed on a range of biomolecules, including proteins and nucleic acids, yielding critical information about different types of interactions. #VirtualScreening #Biotechnology #DrugDiscovery #BiomedicalResearch #MolecularInteractions #ProteinDocking #HealthScience #MedicineOfTheFuture

🌟 Embark on a journey into tailored GPCRs with Eurofins CALIXAR's specialized protein production services. 🔬GPCRs are key targets in drug development, with about 30% of market drugs targeting them due to their involvement in diverse physiological processes and diseases, offering significant potential for therapeutic impact by modulating cellular signaling pathways. At Eurofins CALIXAR, our membrane protein services encompass a comprehensive range of offerings tailored to support drug discovery efforts targeting GPCRs. We specialize in membrane protein expression, solubilization, purification, and characterization, ensuring the delivery of high-quality proteins essential for understanding their structure and function. Additionally, we provide biochemical assays and characterization services to elucidate the mechanisms and interactions of your target GPCRs, facilitating a deep understanding of their role in disease pathways.   🚀 Whether you're in the early stages of research and development or further along in your projects, Eurofins CALIXAR is here to support you in advancing your therapeutic discovery targeting GPCRs. 👉Design your custom proteins: https://lnkd.in/e784nB38   #EurofinsDiscovery #EurofinsDiscoverX #CustomProteins #GPCRs #proteinengineering  

Cell Lysis for Downstream Protein Research 🧪 📑 Cell lysis is an important first step in many research applications, including molecular diagnosis of pathogens, immunoassays for point of care applications, for studying protein function and structure, and in assessing drug response. Different cell lysis techniques are used across many fields, for many types of organisms, and many types of starting materials. However, the underlying goal of each cell lysis technique remains the same: disrupt the cell membrane without causing damage to targeted intracellular components. Check out the sample protocol at https://lnkd.in/g-FT9q8Q #biotech #experiment #research

The Global Metabolomics by Chemical Isotope Labeling LC-MS service provides semi-quantitative, untargeted metabolic profiling by using chemical isotope labeling combined with liquid chromatography and mass spectrometry. This advanced technique allows for precise and high-resolution analysis of a wide range of metabolites in biological samples. By delivering detailed insights into metabolic pathways and biochemical changes, this service supports research in metabolic disease, drug discovery, and systems biology, helping researchers understand complex metabolic networks and identify potential biomarkers. To learn more check out: https://lnkd.in/eiksy3xR #TMIC #Metabolomics #SemiQuantitative #Untargeted #Metabolites #chromatography #biochemical #biomarkers #research #Global

🌟 Unlock the Power of Phenotype MicroArrays™ for Mammalian Cells with Anatech! 🌟   Discover how Phenotype MicroArray™ Mammalian assays can transform your research. Investigate up to 1,400 metabolic and chemical sensitivity phenotypes using 96-well plates pre-loaded with essential compounds like carbon and nitrogen substrates, ions, hormones, cytokines, and anti-cancer agents.   By adding your cells of interest along with biolog’s proprietary redox dye, you can observe colour changes driven by NADH production. These changes are then read and analysed by Odin, giving you valuable insights into cellular behaviour.   Find out all you need to know at https://lnkd.in/dgT3YF_g 🔬✨   #Anatech #PhenotypeMicroArrays #MammalianCells #Biolog #CellResearch #OdinAnalysis #WebChanges #AnatechWebChanges #Anatech

Apoptosis is defined as programmed cellular death. Currently available methods do not allow to measure cell-specific apoptosis in high-throughput. Biocytometry represents a promising method for the single-cell analysis of cellular immunophenotypes. It utilises bioparticles expressing antibody mimetics that recognise antigen markers and in response produce a luminescent reporter signal. In this AppNote the method was used to identify a sub-population of apoptotic HaCaT cells. Click here to read AN395: https://lnkd.in/eEg5xnJW #Biotechnology #Bioanalysis #Luminescence #Biosensor #Cytotoxicity #Biomarker #ReporterGene #CellDeath #Science #Research #LaboratoryWork #LaboratoryEquipment #Lifescience #AssayDevelopment #MicroplateReaders #PlateReader #WeAreBMGLABTECH

"Protocol to identify protein-protein interaction networks in Solanum tuberosum using transient TurboID-based proximity labeling" with Agrisera antibodies to BirA (mutated/TurboID) and matching secondary antibodies. To article: https://lnkd.in/d2csDxzc #proteininteractions

Unveiling protein secrets through antibody-based analytical techniques. 🔬 You can now download the cheat sheet (as a PDF file): https://lnkd.in/etmgF6xp Are you looking for a quick reference sheet for everything related to techniques that use #antibodies for #research? This is the file you need to keep with you. Do you know someone who might benefit from this? Please share this link or the file with them. A big thanks to the #antibody manufacturers who have made wonderful antibodies and been a part of my research: abcam, Cell Signaling Technology (CST), Thermo Fisher Scientific, Proteintech Group, Santa Cruz Biotechnology (SCBT), R&D Systems, MilliporeSigma Thanks to Elena for the document edits. And a shoutout to Jessica, to whom I had promised that I was baking this up. #science #biology #medicine #proteins #lablife

This paper provides valuable insights into enhancing EV-based therapeutic delivery systems and opens up new possibilities for customized cargo delivery using engineered CHO cells. Highlights:** - CHO cells, commonly used for recombinant therapeutic protein production, can also serve as EV producer cells. EVs are promising for delivering bioactive cargo. - Genetic constructs and split green fluorescent protein technology were used to engineer CHO cells for custom EV production. - The custom EV approach achieved significantly higher cargo loading compared to passive strategies. - Successful delivery of engineered cargo was observed in recipient cells. You can read the full article here, https://lnkd.in/g_QFHy4u

Minimizing endotoxin level is critical for cell culture and bioprocessing applications. Why is it important to ensure low endotoxin levels in your formulation or cell culture? Endotoxins, also known as lipopolysaccharides, are toxic pyrogens found in the outer membrane of Gram-negative bacteria and are released into their environment following the lysis of their host cells. These microbes can influence results when exposed to scientific experiments, often leading to discrepancies in molecular biology, assay development, and purification processes. At Boston BioProducts, we offer full customization of your buffers and reagents, including a range of quality control tests such as endotoxin testing. Learn more: https://hubs.la/Q02HFVlp0 #endotoxin #pyrogen #bacteria #gramnegative #LALAssay #microbes #labsafety