MolDrug’s Post

Unveiling protein secrets through antibody-based analytical techniques. 🔬 You can now download the cheat sheet (as a PDF file): https://lnkd.in/etmgF6xp Are you looking for a quick reference sheet for everything related to techniques that use #antibodies for #research? This is the file you need to keep with you. Do you know someone who might benefit from this? Please share this link or the file with them. A big thanks to the #antibody manufacturers who have made wonderful antibodies and been a part of my research: abcam, Cell Signaling Technology (CST), Thermo Fisher Scientific, Proteintech Group, Santa Cruz Biotechnology (SCBT), R&D Systems, MilliporeSigma Thanks to Elena for the document edits. And a shoutout to Jessica, to whom I had promised that I was baking this up. #science #biology #medicine #proteins #lablife

Save big on bioscience research essentials! 🔬 Dive into our 50% OFF sale on Protease Inhibitor Cocktail for Mammalian Cells and Tissue (PIC-2, A-0014). Don’t miss out! PIC-2 is a mixture of protease inhibitors that will inhibit many proteases including aspartic, cysteine, serine, metalloproteases, and aminopeptidases. To learn more or order online, go to: https://lnkd.in/gzv7GKXr Email or call us if you have any questions or want to place an order! #ResearchEssentials #ProteaseInhibitor #ProteaseInhibitorCocktail #LabLife #Sale #Biosciences #LifeSciences #Research

This week, meet our team in the UK at the British Mass Spectrometry Society - BMSS and the British Society for Proteome Research (BSPR) Super Meeting! Learn how MOBIE can revolutionize your lab workflows. MOBIE offers: - Superior resolution for confident identification of complex samples. - Increased throughput to get more results faster. - Unprecedented reproducibility for reliable data you can trust. - Greater instrument uptime for maximized efficiency. - Simplified workflows for a smoother user experience. Meet our CEO, Melissa Sherman, Ph.D., and she'll help you see how MOBIE can push the boundaries of mass spec. Learn more: https://hubs.ly/Q02Nqd2f0 MOBILion #MassSpec #ProteinCharacterization #HRIMAdvancements #TeamMassSpec #bioanalytical #MassSpectrometry #SeparationSciences #SLIM #biopharma #biotherapeutics #Glycans #Isomerome #HRIM #molecules #peptides #oligos #antibodies #proteomics #metabolomics #Science #Research #MS #Bioinformatics #lipidomics #LCMS #HPLC

In addition to identifying chemical starting points for early drug discovery processes, DNA-encoded library (DEL) technology has now expanded to new applications, including the discovery of bifunctional affinity ligands historically considered difficult to develop. At this year’s Gordon Research conference, WuXi AppTec presented a poster describing how DEL can enable the rapid discovery of novel affinity ligands, such as tracers for biochemical and cellular assays, and building a ‘universal’ chimeric antigen receptor (CAR) to enhance the control and safety profile of CAR-based immunotherapies. Click 👇 to view our poster. Questions? Contact us by clicking here: https://lnkd.in/eG97YXCs #Biotech #Biopharma #DrugDiscovery #GRC #DEL #CART https://lnkd.in/efst8-S4

The Global Metabolomics by Chemical Isotope Labeling LC-MS service provides semi-quantitative, untargeted metabolic profiling by using chemical isotope labeling combined with liquid chromatography and mass spectrometry. This advanced technique allows for precise and high-resolution analysis of a wide range of metabolites in biological samples. By delivering detailed insights into metabolic pathways and biochemical changes, this service supports research in metabolic disease, drug discovery, and systems biology, helping researchers understand complex metabolic networks and identify potential biomarkers. To learn more check out: https://lnkd.in/eiksy3xR #TMIC #Metabolomics #SemiQuantitative #Untargeted #Metabolites #chromatography #biochemical #biomarkers #research #Global

📊 Deformulation Assays for #CRISPR LNPs!?! Best for last? Our final Oligos, Oligos, Oligos! webinar will be held Nov 21st at 9 am EST / 15:00 CST. I know many industry teammates were just at the International mRNA Health Conference and are probably overloaded with new info, but you won’t want to miss this! Big thanks to all of our featured speakers in this November’s webinar series. I’ll admit I have a favorite; we saved the best for last! What are you to do as an analytical scientist working on a new multi cargo #LNP? You’re handed a formulated particle and need to start qualifying new methods for component concentrations, their integrity and more… Acuitas Therapeutics, Inc., known for breakthroughs in synthetic lipids and novel LNP formulations, has been working with us on assays of just this sort. We have a choose-your-own-adventure scenario to present: choose a novel size exclusion or rapid IP-RP method with some important method robustness tweaks. These are brilliant experimentation stories from 2 talented scientists: Mateusz Imiołek and Razvan Cojocaru! 🗓️ Register here: https://lnkd.in/e2CCvDgV #GeneTherapy #CellTherapy #Biotechnology #LifeatWaters #AnalyticalChemistry Waters Corporation ————————— I’m Matt Lauber - an analytical biochemist who loves separating biomolecules, detecting masses, and all things biotechnology! ☑️ Follow & subscribe 🔔

A NEW POWERFUL NATURAL DEFENSE Lactive is a synergistic patented product, born from the observation of the extraordinary mechanism with which babies defend themselves from pathogen attacks. From the mother's milk, in fact, the baby, thanks to its natural enzymes, generates these peptides that effectively defend it. 👉 Antiviral Activity 👈 Scientific evidence shows that it is able to prevent viral infections by preventing the virus from entering the host cell. BIBLIOGRAPHY Effects of Lactoferrin and Lactoferricin on the Release of Interleukin 8 from Human Polymorphonuclear. Ichizo Shinoda, Mitsunori Takase, Yasuo Fukuwatari, Seiichi Shimamura, Manfred Köller & Wolfgang König (1996) Leukocytes, Bioscience, Biotechnology, and Biochemistry, 60:3, 521-523, DOI: 10.1271/bbb.60.521 Find out more, Contact us! customerservice_italy@bict.it #lactive #lactoferricin #naturalhealt #naturalpeptide #boostyourproduct #lactoferrin #innovation #biotech #medicaldevice #ingredienteattivo #lattoferricina #antivirale #antibatterico #immunostimolante #microbioma https://lnkd.in/evVgM4KM

Identifying novel tractable druggable pockets using covalent fragment-based screening. Covalent fragment-based screening has emerged as a powerful approach in drug discovery for prioritization of tractable protein targets that are: 1. Amenable to binding small molecules and 2. Alter disease biology upon binding The use of irreversible covalent fragment screening allows: A. Identification of hits for challenging to target proteins B. Proteome wide screening in complex biological mixture C. Establishing functionality with modestly binding hits without extensive medicinal chemistry optimization, reducing cost and time in making a go/no-go decision.

New App Note!: "Enhancing Size-Exclusion Chromatography of Large Biomolecular Analytes With Rigorously Designed GTxResolve™ Premier SEC 1000 Å 3 µm Columns." Benefits: ⭐ Novel ethylene bridged HO-PEO bonded 3 µm particles that provide improved chemical inertness and high efficiencies 💫 ⭐ Excellent resolution for large biomolecules, including high molecular weight protein complexes and nucleic acids 🧬 ⭐ Reproducibility confirmed by quality control batch testing with two molecule types - both protein and nucleic acid-based samples ✅ ⭐ Enhanced chromatographic performance manifests as higher signal, sharper peaks, and more plates 📈 ⭐ Minimal adsorption and significantly reduced secondary interactions to the column matrix to facilitate more robust results with more mobile phase compositions 🚀 #chromatography #biomolecules #proteins #nucleicacids #science #research #biomaterials #lipidnanoparticles #nanoparticles #analyticalchemistry #cellandgenetherapy #ATMP #newmodalities Waters Corporation Waters | Wyatt Technology

What is dbDNA™? Named after its schematic structure, dbDNA™ is a minimal, linear, double stranded and covalently closed DNA construct that can encode long, complex, or unstable DNA sequences, eliminates bacterial sequences and has a strong expression profile. Learn how Touchlight is making DNA simple by moving away from restrictive biological approaches and instead using enzyme biochemistry, eliminating the need for bacterial sequences: https://lnkd.in/e8meAqY #biotech #drugdevelopment #biopharma #pharma