SignalFire

Last night, we co-hosted an MCP Lightning Talks event with Jamsocket at our NYC office, where industry experts unpacked Anthropic’s Model Context Protocol and its game-changing impact. It was great to discuss how MCP is bridging the gap between agents and applications with some of the brightest minds in tech. Thank you to everyone who joined us (we had 262 signups 🙌 ), and made the evening unforgettable. Special thanks to our hosts Ryan Wexler and Paul Butler. Our lineup of speakers included: - Paul Butler (Founder of Jamsocket) - Alex Kesling (CTO of Caurus) - Sarmad Qadri (Co-founder & CEO of LastMile AI) - Andrew Hamilton (CTO of Layer) If you missed out, check out our video recap for all the insights and learn about our upcoming events. Let’s keep pushing the boundaries of what’s possible with AI! (Link to video recap in comments) #AI #Developer #MCP #ModelContextProtocol #LLM #MachineLearning #AIInfra #AIAgents #DeveloperTools

Congrats to SignalFire portfolio company Plural on this milestone! 👏 We're excited to see how Samuel Weaver and his stellar team continue to push the boundaries and redefine enterprise Kubernetes management.

As investors on the front lines of AI innovation, we’re seeing specialized vertical SaaS solutions rapidly outpace one-size-fits-all approaches across healthcare, logistics, finance, manufacturing, and more. The potential of vertical AI represents a $6 trillion opportunity in annual services spend in the U.S. alone—10 times the $600 billion market cap of all cloud software combined. In this article, SignalFire‎'s Chris Farmer and Wayne Hu‎ break down the key frameworks fueling this new wave of AI vertical SaaS, where domain expertise and data moats are the real differentiators. (Link in comments.) #AI #VerticalSaaS #VerticalAI #GenAI

Curious about how AI is fast-tracking drug discovery? Meet Tomasz Osinski, PhD, Research Computing Facilitator in Life Science at the University of Southern California whom we caught up with at NVIDIA GTC. Thomasz is on the front lines of high-performance computing (HPC) and guides faculty and students on how to fast-track discoveries by tapping into innovations like AlphaFold and AI-driven 3D protein modeling for drug discovery. He joined Jarod Reyes to share how AI is reshaping biomedical research, creating new opportunities, and making breakthroughs more accessible for students, researchers, and startups. Watch the interview here: https://lnkd.in/gsNTZUqD #AI #LifeSciences #HealthcareAI #Pharma #HealthcareInnovation #DrugDiscovery

Ever had to build an HR function from scratch—multiple times? This team has. Join Shelby Wolpa, Kelli Doré, Bryce Rattner Keithley, and SignalFire partner Heather Doshay at Pando's Horizon 2025 on April 29 as they reveal their tried-and-true playbook for fast-growth teams. You'll learn: - How to prioritize people initiatives on a lean budget - The key systems you can’t skip - Pitfalls to avoid with distributed teams RSVP here → https://lnkd.in/d2etyjiZ #PandoHorizons2025 #talent #peoplemanagement #HR

We’re in the thick of the action at #NVIDIAGTC, surrounded by experts and conversations on the latest AI innovations. SignalFire's Jarod Reyes caught up with Craig Dennis from Cloudflare on how AI is fueling everything from seamless front-end dev to automating everyday tasks he hates doing. 🤖 Craig's team recently launched an agents framework that transforms everyday experiences: - For example, you snap a photo of a concert poster → AI extracts band info → researches the artist → creates a playlist → sends reminder emails before their show What would have required multiple specialized libraries and complex code just a few years ago now happens through AI in one seamless flow! 💡 Key insights from our conversation: - Start with structured outputs to see what's possible before custom-building solutions - AI has progressed far beyond "predicting the next token" — today's models are genuinely reasoning - The UI development process has been revolutionized — Craig literally dictates app requirements while driving his kids to school and comes home to completed code - When to throw it all at a large language model vs. when to code from scratch. Plus, hear his take on how AI enthusiasm in San Francisco compares to Portland. His advice for engineers starting with AI is to begin with the tasks they really don't want to do. That's where AI can make the biggest, immediate impact. Watch the full interview here: https://lnkd.in/g7SnfwPR #AI #CloudComputing #GTC2025 #AIAgents

It's been an incredible week at #NVIDIAGTC, and the SignalFire team has been busy! Yesterday Ryan Wexler had the chance to flip the script and present our “reverse pitch” to startups. We’re a VC firm built like a startup—which means data science and AI aren’t just buzzwords; they’re the backbone of how we help founders from day one. We’re actively investing across the AI stack—model development, dev infra, real-world applications—and we back it all up with our firm's proprietary Beacon AI platform, which tracks 650M employees and 80M companies. This gives us an unmatched data advantage in identifying and supporting world-class startups. It’s an exciting time to be building, and we'd love to see how SignalFire can help fuel your vision. #GTC2025 #GTC25 #ML #Startups NVIDIA GTC

In an unprecedented move, Snowflake and Databricks have both invested in our portfolio company Anomalo—a validation of the AI-powered data quality platform that Elliot Shmukler and team have built. 👏 As AI adoption explodes across every industry, bad data equals bad outcomes. Anomalo ensures you can trust your data before it powers mission-critical AI or business decisions—safeguarding against the brand-killing mistakes we’ve seen in the headlines recently. The fact that these two competitive powerhouses both recognize Anomalo's value speaks volumes about the mission-critical need for robust data quality monitoring in today's AI-first world. Huge congratulations to Elliot and the entire Anomalo team on this milestone! Your dedication to data reliability was clear from the start. #DataQuality #AI #VC

Heading to NVIDIA GTC in San Jose? Don’t miss our exclusive "Agentic AI Founder & Developer Dinner" with NVIDIA, BAG Ventures, Tensor Ventures, and Citizens Bank. If you’re building enterprise AI Agents, this is your chance to connect with top VCs and innovators—all in one room. We’re nearly at capacity, so comment "AGENTS" on Brandon Johnson's post below and he'll DM you the RSVP link. You can also catch SignalFire's Jarod Reyes and Ryan Wexler at the Reverse VC Pitch event, where investors from top VC firms will present their firms and their vision for the future of their core industries. This unique event flips the script, allowing investors to pitch directly to founders and entrepreneurs. #NVIDIAGTC #GTC25

We’re teaming up with #GenAI4Pharma to spotlight an all-star BioPharma lineup at our San Francisco office. Meet our healthcare dream team (including Sooah Cho) and our portfolio founders as they share how #GenerativeAI is turbocharging #BioPharma from R&D all the way through clinical and commercialization. If you're looking to define the future of healthcare, you won’t want to miss this.