SignalFire

💰Our SignalFire team is ready to partner with founders to usher in a new era of AI-enabled #Health & #Longevity for all. 🤯 But I'll admit that I've never felt a deeper sense of responsibility, given these powerful #AI technologies are poised to fundamentally disrupt the very fabric of society. Bill Gates suggests that "AI will replace many doctors and teachers—humans won't be needed 'for most things' within 10 years." 🔎 This is why I've been obsessed with how we can monitor, evaluate, and deploy AI safely at scale in healthcare. I had the privilege of sitting down with Robert Wachter - University of California, San Francisco, Justin Norden, MD, MBA, MPhil - Qualified Health, Munjal Shah - Hippocratic AI, and Abhinav Shashank - Innovaccer to debate these questions: ❓Will we live in an AI-Automated (vs AI-Augmented) care delivery world by 2030? ❓When do we think the US government will have regulations to enforce standards for AI evaluation and monitoring in healthcare? ❓Will the battle royale between payor AI-agents and provider AI-agents potentially drive up overall healthcare administrative costs even higher in this next chapter? 📽️ If you missed it, check out the videos from the Health AI Summit that we recently co-hosted alongside Travis May, Shaper Capital, Transformation Capital, a16z Bio + Health, and others in comments below. 📢 We'll be continuing these conversations to shape the Future of Health AI at Health Evolution this week. DM me if you'd like to join the discussions with Eric Larsen and our team Yuanling Yuan & Sahir Raoof. 🙌

SignalFire‎ just closed on over $1 billion in new capital, pushing our AUM to approximately $3 billion! We’re grateful for our investors’ confidence in our AI-native approach, thesis-driven investment strategy, and in-house operational expertise. With our proprietary Beacon AI platform, we’re not just spotting trends—we’re powering early-stage startups that are set to redefine industries from healthcare and cybersecurity to infrastructure and beyond. We’ll use this fresh capital to continue backing visionary founders transforming bold ideas and theoretical AI into market-defining companies. A huge thank you to our founders, investors, and community for your continued trust and support. We can’t wait to build the next era of applied AI together.  (Link to the announcement in comments)

The healthcare system failed Jeremy and his family. His struggle navigating the system became a painful turning point—and the inspiration for Solace, a company he built to make sure no one has to navigate our healthcare system alone. We’re proud to partner with Solace in their $60M Series B, led by Jean-Paul (J.P.) Sanday at Menlo Ventures, alongside Bryan at Craft, Alexa at Inspired Capital, and Katie Reiner at Torch Capital. Solace pairs patients with expert advocates—like nurses, social workers, and health administrators—who handle everything from appointment bookings to insurance claims. The impact is deeply personal, but the results speak loudly: Solace is elevating the standard of care and lowering costs. For the 66 million people on Medicare and 129 million with chronic conditions, our healthcare system is especially hard to navigate. Solace is already in-network with all major Medicare Advantage plans and commercial coverage is on the horizon. At SignalFire, we look for founders who are building foundational pillars of a more open, accessible and patient-centric healthcare system. We’re proud to partner with Solace and Jeremy and Sara on this ambitious and impactful mission.

Last night, we co-hosted an MCP Lightning Talks event with Jamsocket at our NYC office, where industry experts unpacked Anthropic’s Model Context Protocol and its game-changing impact. It was great to discuss how MCP is bridging the gap between agents and applications with some of the brightest minds in tech. Thank you to everyone who joined us (we had 262 signups 🙌 ), and made the evening unforgettable. Special thanks to our hosts Ryan Wexler and Paul Butler. Our lineup of speakers included: - Paul Butler (Founder of Jamsocket) - Alex Kesling (CTO of Caurus) - Sarmad Qadri (Co-founder & CEO of LastMile AI) - Andrew Hamilton (CTO of Layer) If you missed out, check out our video recap for all the insights and learn about our upcoming events. Let’s keep pushing the boundaries of what’s possible with AI! (Link to video recap in comments) #AI #Developer #MCP #ModelContextProtocol #LLM #MachineLearning #AIInfra #AIAgents #DeveloperTools

Congrats to SignalFire portfolio company Plural on this milestone! 👏 We're excited to see how Samuel Weaver and his stellar team continue to push the boundaries and redefine enterprise Kubernetes management.

As investors on the front lines of AI innovation, we’re seeing specialized vertical SaaS solutions rapidly outpace one-size-fits-all approaches across healthcare, logistics, finance, manufacturing, and more. The potential of vertical AI represents a $6 trillion opportunity in annual services spend in the U.S. alone—10 times the $600 billion market cap of all cloud software combined. In this article, SignalFire‎'s Chris Farmer and Wayne Hu‎ break down the key frameworks fueling this new wave of AI vertical SaaS, where domain expertise and data moats are the real differentiators. (Link in comments.) #AI #VerticalSaaS #VerticalAI #GenAI

Curious about how AI is fast-tracking drug discovery? Meet Tomasz Osinski, PhD, Research Computing Facilitator in Life Science at the University of Southern California whom we caught up with at NVIDIA GTC. Thomasz is on the front lines of high-performance computing (HPC) and guides faculty and students on how to fast-track discoveries by tapping into innovations like AlphaFold and AI-driven 3D protein modeling for drug discovery. He joined Jarod Reyes to share how AI is reshaping biomedical research, creating new opportunities, and making breakthroughs more accessible for students, researchers, and startups. Watch the interview here: https://lnkd.in/gsNTZUqD #AI #LifeSciences #HealthcareAI #Pharma #HealthcareInnovation #DrugDiscovery

Ever had to build an HR function from scratch—multiple times? This team has. Join Shelby Wolpa, Kelli Doré, Bryce Rattner Keithley, and SignalFire partner Heather Doshay at Pando's Horizon 2025 on April 29 as they reveal their tried-and-true playbook for fast-growth teams. You'll learn: - How to prioritize people initiatives on a lean budget - The key systems you can’t skip - Pitfalls to avoid with distributed teams RSVP here → https://lnkd.in/d2etyjiZ #PandoHorizons2025 #talent #peoplemanagement #HR

We’re in the thick of the action at #NVIDIAGTC, surrounded by experts and conversations on the latest AI innovations. SignalFire's Jarod Reyes caught up with Craig Dennis from Cloudflare on how AI is fueling everything from seamless front-end dev to automating everyday tasks he hates doing. 🤖 Craig's team recently launched an agents framework that transforms everyday experiences: - For example, you snap a photo of a concert poster → AI extracts band info → researches the artist → creates a playlist → sends reminder emails before their show What would have required multiple specialized libraries and complex code just a few years ago now happens through AI in one seamless flow! 💡 Key insights from our conversation: - Start with structured outputs to see what's possible before custom-building solutions - AI has progressed far beyond "predicting the next token" — today's models are genuinely reasoning - The UI development process has been revolutionized — Craig literally dictates app requirements while driving his kids to school and comes home to completed code - When to throw it all at a large language model vs. when to code from scratch. Plus, hear his take on how AI enthusiasm in San Francisco compares to Portland. His advice for engineers starting with AI is to begin with the tasks they really don't want to do. That's where AI can make the biggest, immediate impact. Watch the full interview here: https://lnkd.in/g7SnfwPR #AI #CloudComputing #GTC2025 #AIAgents

It's been an incredible week at #NVIDIAGTC, and the SignalFire team has been busy! Yesterday Ryan Wexler had the chance to flip the script and present our “reverse pitch” to startups. We’re a VC firm built like a startup—which means data science and AI aren’t just buzzwords; they’re the backbone of how we help founders from day one. We’re actively investing across the AI stack—model development, dev infra, real-world applications—and we back it all up with our firm's proprietary Beacon AI platform, which tracks 650M employees and 80M companies. This gives us an unmatched data advantage in identifying and supporting world-class startups. It’s an exciting time to be building, and we'd love to see how SignalFire can help fuel your vision. #GTC2025 #GTC25 #ML #Startups NVIDIA GTC