Dana-Farber Cancer Institute

Researchers presented new research studies during the 2025 Society of Gynecologic Oncology (SGO) Annual Meeting, held March 14-17. The Dana-Farber led studies exemplified innovative clinical research for the improvement of treatment for gynecologic cancers. Panagiotis Konstantinopoulos, MD, PhD, the Velma Eisenson Chair for Clinical and Translational Research in Gynecologic Oncology, presented findings from the RESOLVE study of a phase 2 clinical trial showing that treatment with metformin, letrozole, and abemaciclib for recurrent estrogen receptor-positive endometrial cancer is safe and appears to induce deeper and more durable responses than letrozole and abemaciclib alone. The team initiated the trial based on preclinical research suggesting synergy between the three drugs, which together inhibit the estrogen receptor, CDK4/6, and PI3K pathways. All 25 patients in the trial received the three medicines. At a median of 17 months of follow-up, three patients had a complete response, five a partial response, and sixteen had stable disease. Based on next-generation sequencing of tumors, the team found that all the complete and partial responses were observed in patients with no specific molecular profile (NSMP) endometrial cancers without RB1 or CCNE1 mutations, suggesting this patient group will derive the most benefit from this combination. "Addition of metformin to hormonal therapy and CDK4/6 inhibition with abemaciclib demonstrated encouraging and durable evidence of activity in NSMP endometrial cancers providing support for simultaneous inhibition of ER, CDK4/6 and PI3K pathways in this setting," said Konstantinopoulos. Elizabeth K. Lee, MD presented results from a phase 1/2 clinical trial reporting that Rinatabart sesutecan (Rina-S), an investigational, novel antibody-drug conjugate directed at folate receptor alpha (FRα), showed encouraging preliminary antitumor activity as a single agent in a dose expansion cohort of patients with advanced ovarian cancer. The open-label, multicenter phase 1/2 study tested Rina-S in a cohort of 42 patients with heavily treated advanced ovarian cancer. Patients received one of two doses of Rina-S (100 mg/m2 or 120 mg/m2) every three weeks. After a median of 24 weeks of follow-up, 22.7% of patients taking the lower dose and 55.6% of patients taking the higher dose had confirmed objective responses, with 2 complete responses in the higher dose group. Side effects included low blood counts and gastrointestinal distress. The results support further testing of single-agent Rina-S at 120mg/m2; enrollment of patients with platinum resistant ovarian cancer is ongoing in a phase 2 study (RAINFOL-OV1) and in a randomized phase 3 study (RAINFOL-OV2/GOG-3107, NCT06619236). "Rina-S, a novel FRa-directed antibody-drug conjugate, demonstrated encouraging activity in patients with ovarian cancer, across FRa expression levels," said Lee. "These findings support the further study of Rina-S in ovarian cancer."

Meet Yuxin Liu, MD, who treats patients with multiple myeloma and other plasma cell disorders. Her clinical research focuses on novel therapies in newly diagnosed and relapsed multiple myeloma. https://bit.ly/41VUyUW

Did you know PFAS, also called "forever chemicals," are linked to cancer? Tim Rebbeck, PhD, explains how PFAS exposure can cause DNA damage and immune system changes, increasing the risk of kidney and testicular cancers. While PFAS exposure often comes from drinking water, the best way to reduce overall cancer risk is by avoiding or quitting smoking, limiting processed foods and alcohol, and maintaining an overall healthy lifestyle where possible.

Last week, we had the pleasure of hosting legislators from the Health Care Financing Committee for a tour of the Yawkey Building on our Longwood campus. Highlights of the tour included Friends’ Place, our pharmacy, clinical labs, treatment rooms, and the healing garden. Following the tour, they met with our President and CEO, Benjamin L. Ebert, MD, PhD, to discuss the evolving healthcare landscape in Massachusetts.   We appreciate the opportunity to connect with many legislators, including Committee’s Cochairs, Senator Cindy Friedman, and Representative John Lawn. Their support and advocacy are essential in driving our mission of advancing expertise and innovation, expanding access to care, and reducing the impact of cancer in the Commonwealth and around the world.

Jorge Castillo, MD, and Shayna Sarosiek, MD, highlight the impact the Bing Center has in advancing novel agents for Waldenström’s Macroglobulinemia. https://bit.ly/3DzTXiq

This weekend, thanks to the support of the Boston Red Sox, Dana-Farber and The Jimmy Fund supporters gathered at Fenway Park to celebrate the impact of the Dana-Farber Campaign. The event highlighted the power of community and the critical work that our donors make possible as we continue to defy cancer together. Attendees engaged with The Message of Hope wall, an interactive display showcasing caring and inspiring messages that will bring hope to patients and their families. Performers and speakers represented the diversity, dedication, and commitment of our community. President and CEO Benjamin L. Ebert, MD, PhD, shared his vision for revolutionizing cancer care and research. Our patients, supporters, and faculty shared stories of impact and hope. Thank you to everyone who attended and all those who continue to partner with us to change the future of cancer care.

Save the date for our 12th Annual Cancer Disparities Research Symposium with keynote speaker Rachel Issaka, MD, MAS. Register here: https://bit.ly/4hBo9IQ

Underneath every Dana-Farber lab coat is a real-life superhero who has dedicated their life to defying cancer. Thank you to all doctors at Dana-Farber Cancer Institute and beyond for their compassionate care, and for making a difference for patients and families every day! #NationalDoctorsDay

With emerging therapies and ongoing trials, Giada Bianchi, MD, and colleagues are leading significant advancements in treating AL amyloidosis and improving quality of life for patients. https://bit.ly/3FoEPFq

During Child Life Specialist Month, we’re shining a light on the incredible team that helps young patients navigate their diagnosis, treatment, and visits with comfort and confidence. Through play, education, and emotional support, our child life specialists turn uneasy moments into empowering experiences, helping kids feel safe, informed, and cared for every step of the way. 💙