Unraveling cellular phosphorylation networks using computational biology

Sep 25, 2008Download as ppt, pdf1 like533 views

Lars Juhl Jensen

BRIC/LEO Minisymposium on Protein Kinases in Health and Disease, Copenhagen Biocenter, Copenhagen, September 26, 2008

Oda & Kitano, Molecular Systems Biology , 2006

Linding, Jensen, Ostheimer et al., Cell , 2007

Miller, Jensen et al., Science Signaling , 2008

Jensen et al., Nucleic Acids Research , 2008

Korbel et al., Nature Biotechnology , 2004

Letunic & Bork, Trends in Biochemical Sciences , 2008

von Mering et al., Nucleic Acids Research , 2005

Acknowledgments NetworKIN.info Rune Linding Gerard Ostheimer Francesca Diella Karen Colwill Jing Jin Pavel Metalnikov Vivian Nguyen Adrian Pasculescu Jin Gyoon Park Leona D. Samson Rob Russell Peer Bork Michael Yaffe Tony Pawson NetPhorest.info Martin Lee Miller Francesca Diella Claus Jørgensen Michele Tinti Lei Li Marilyn Hsiung Sirlester A. Parker Jennifer Bordeaux Thomas Sicheritz-Pontén Marina Olhovsky Adrian Pasculescu Jes Alexander Stefan Knapp Nikolaj Blom Peer Bork Shawn Li Gianni Cesareni Tony Pawson Benjamin E. Turk Michael B. Yaffe Søren Brunak STRING.embl.de Christian von Mering Michael Kuhn Manuel Stark Samuel Chaffron Philippe Julien Tobias Doerks Jan Korbel Berend Snel Martijn Huynen Peer Bork

The document discusses Lars Juhl Jensen's work in data integration and systems biology. It describes some of his key projects including developing methods to map phosphorylation networks, build interaction networks using genomic context data from multiple species, and create the NetworKIN tool to predict kinase-substrate relationships by integrating sequence motifs, protein-protein interactions, and phosphorylation data. The work has helped provide more accurate predictions of phosphorylation sites and their regulating kinases by taking into account protein context and experimental validation.

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