Synchronous Reads, Asynchronous Writes refers to an architectural approach where data reads are performed synchronously through services, while data writes are performed asynchronously through a messaging system. This allows for decoupling of services, horizontal scaling of reads and writes, and loose coupling between systems. The key aspects are performing JSON RESTful reads through services like Sinatra, and pushing writes to a messaging system like RabbitMQ with routing keys to trigger downstream processing. This approach can help solve issues with monolithic Rails applications that do not scale effectively.