Tommi Reiman discusses optimizing Clojure performance and abstractions. He shares lessons learned from optimizing middleware performance and JSON serialization. Data-driven approaches can enable high performance while maintaining abstraction. Reitit is a new routing library that aims to have the fastest performance through techniques like compiled routing data. Middleware can also benefit from data-driven approaches without runtime penalties. Overall performance should be considered but not obsessively, as many apps do not require extreme optimization.