Monte Carlo simulation allows businesses to model uncertain situations by simulating random outcomes thousands of times on a computer. It can be used to estimate probabilities, determine optimal decisions under risk, and evaluate investments. The document describes how to simulate random variables in Excel using functions like RAND(), VLOOKUP(), and NORMINV(). It provides an example of a greeting card company using Monte Carlo simulation over 1,000 iterations to determine the production quantity with the highest expected profit under variable demand.