ELIXIR Proteomics Community - Connection with nf-core
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ELIXIR Proteomics Community and the Nextflow nf-core community - a meeting to discuss the joint efforton the standardization of analytical workflows. Find out more at https://nf-co.re/
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Contact us:
info@inevitablecloud.org
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---
## 🦠 **ANTIMALARIAL DRUGS OVERVIEW**
---
### ✅ **1. Classification of Antimalarial Drugs**
#### **A. Based on Stage of Action:**
* **Tissue Schizonticides**: Primaquine
* **Blood Schizonticides**: Chloroquine, Artemisinin, Mefloquine
* **Gametocytocides**: Primaquine, Artemisinin
* **Sporontocides**: Pyrimethamine
#### **B. Based on Chemical Class:**
| Class | Examples |
| ----------------------- | ------------------------ |
| 4-Aminoquinolines | Chloroquine, Amodiaquine |
| 8-Aminoquinolines | Primaquine, Tafenoquine |
| Artemisinin Derivatives | Artesunate, Artemether |
| Quinoline-methanols | Mefloquine |
| Biguanides | Proguanil |
| Sulfonamides | Sulfadoxine |
| Antibiotics | Doxycycline, Clindamycin |
| Naphthoquinones | Atovaquone |
---
### ⚙️ **2. Mechanism of Action (MOA)**
| Drug/Class | MOA |
| ----------------- | ----------------------------------------------------------------------- |
| **Chloroquine** | Inhibits heme polymerization → toxic heme accumulation → parasite death |
| **Artemisinin** | Generates free radicals → damages parasite proteins |
| **Primaquine** | Disrupts mitochondrial function in liver stages |
| **Mefloquine** | Disrupts heme detoxification pathway |
| **Atovaquone** | Inhibits mitochondrial electron transport |
| **Pyrimethamine** | Inhibits dihydrofolate reductase (
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- 14. Adding a pipeline Step 1 2 3 Join the nf-core community #new-pipelines
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