This document provides advanced performance tuning tips for databases. It discusses challenges of tuning like SQL statements being hard to tune and requiring expertise. It recommends using response time analysis to identify statements for tuning by examining wait events and times. Details about SQL like execution plans, metrics, indexes and statistics should be gathered. The SQL can then be tuned by looking for performance inhibitors and making small changes. Several case studies are presented on tuning specific SQL statements and the benefits of monitoring are discussed.