Researchers from the OGI have demonstrated how extracellular vesicle RNA content can be used as circulating biomarkers. In a recent study published in Molecular Therapy: Methods & Clinical Development, they used PRPF31 mutant RPE cells to show that EVs released from these cells contain polyA RNA and miRNAs associated with de-differentiation and degeneration. Massachusetts Eye and Ear Massachusetts General Hospital Broad Institute of MIT and Harvard Harvard Medical School #EVs #RNA #Biomarkers #Retinaldegeneration https://lnkd.in/enCkEYNt
Ocular Genomics Institute
Research Services
Boston, Massachusetts 197 followers
The Ocular Genomics Institute translates genomic medicine into precision ophthalmic care.
About us
The Ocular Genomics Institute (OGI) aims to translate genomic medicine into precision ophthalmic care for patients with inherited eye disorders. OGI researchers are working to achieve this goal through a combination of efforts, including: -Laboratory-based translational research on functional genetics, genomics, IPS-derived models of disease and genome editing. -The application of modern gene therapy technologies to identify new disease genes and improve inherited retinal disorder diagnosis -Clinical research directed toward the development of clinical trials of novel gene therapies and participation by our patients and clinicians in a number of gene therapy trials including the first in human study of in vivo CRISPR-Cas9 gene editing. -Providing state-of-the-art clinical care for patients with ophthalmic genetic disorders, including comprehensive genetic testing. -Providing DNA extraction and storage as part of the OGI BioBank for researchers to store samples long term for future genomics studies. The OGI multidisciplinary team works with several other departments and teams to achieve its mission. Via the Genomics Core, the OGI provides clinical genetic diagnostic testing and research services, including whole exome and whole genome sequencing,and copy number variant analyses, to both internal and external institutions.
- Website
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https://oculargenomics.meei.harvard.edu/
External link for Ocular Genomics Institute
- Industry
- Research Services
- Company size
- 51-200 employees
- Headquarters
- Boston, Massachusetts
- Specialties
- Inherited retinal disorders, genomics, and clinical trials
Updates
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https://lnkd.in/eVXFghtf Make your voice heard! We need science and cannot be silent in the face of government funding cuts!
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https://lnkd.in/eTQr_MY5 This story never gets old - a great example of why the members of the OGI come to work each and every day.
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The genetic background of a model may contain additional variants that contribute to the disease and complicate phenotype rescue. In this manuscript, we utilize prime editing technology to safely introduce point mutations into hiPSCs and generate isogenic disease models. With our optimized system, we successfully address the low efficiency typically observed in hiPSCs. Learn more here: https://lnkd.in/efyuKP_i
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https://lnkd.in/eM5fzHFE So inspiring to see the results of many years of work changing the lives of our patients. This is why we come to work every day!
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https://lnkd.in/eD2Gs2ui Gene editing trial shows promise for treatments!