Vellon Space’s Post

Treating liver cancer with microrobots piloted by a magnetic field. Canadian researchers led by Montreal radiologist Gilles Soulez have developed a novel approach to treat liver tumours using magnet-guided microrobots in an MRI device. Read: https://lnkd.in/eZSp3n_p Centre de recherche du CHUM (CRCHUM) CHUM - Centre hospitalier de l'Université de Montréal Université de Montréal Life Science Robotics Sylvain Martel Polytechnique Montréal Urs Hafeli The University of British Columbia National Research Council Canada / Conseil national de recherches Canada Canadian Institutes of Health Research | Instituts de recherche en santé du Canada Fonds de recherche du Québec Association des radiologistes du Québec #sciencesdelavie #biotechnology #biotechnology #innovation #innovations #research #sciences #medicaments #research #drugresearch #laboratories #labs #chemistry #chemistry #biology #biologie #biopharma #rna #rnatherapeutics #arn #revolution #happy

A leading nanomedicine researcher at The University of Manchester has received a £1.3m grant to advance research on Alzheimer’s and glioblastoma https://lnkd.in/e35Rbz33

A leading nanomedicine researcher at The University of Manchester has received a £1.3m grant to advance research on Alzheimer’s and glioblastoma https://lnkd.in/e35Rbz33

🔬 Lab Spotlight: Cellular Biophysics Lab, IIT Bombay 🔬 Today, we’re showcasing the cutting-edge research at the Cellular Biophysics Lab, IIT Bombay 🌟. Led by Prof. Dr. Shamik Sen, the lab explores the biophysical principles underlying cellular behaviors and mechanics! ✨ 🔬 Key Research Areas🔬 ◻ Cancer Metastasis: Investigating how the extracellular matrix (ECM) influences cancer cell motility and invasion. The lab examines how physical and chemical cues drive metastasis through tumor microenvironment interactions. 🧬🔍 ◻ Stem Cell Mechanobiology: Understanding how mechanical signals in the stem cell niche regulate embryonic stem cell (ESC) pluripotency. Insights from this work are applied to create synthetic substrates for ESC differentiation. 🌱🔬 ◻Tissue Engineering: Exploring how ECM properties, like stiffness and porosity, affect cell behavior. Biomaterials with tunable mechanics are utilized to mimic ECM features for engineering applications. 🧫🛠️ 🔗 Explore more of their groundbreaking work: Lab Homepage: https://lnkd.in/gsywHybW ✍🏻 Credits: 🎨 Poster: Abhilaya Makkuva 📝 Content: Md Rashid Alam #NGSF #Biophysics #IITBombay #CellularMechanics #ResearchInnovation

https://lnkd.in/d2WDuyR5 University of Pennsylvania School of Engineering and Applied Science engineers say they have modified lipid nanoparticles (LNPs) to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This breakthrough marks a significant step toward potential next-generation mRNA treatments for neurological diseases like Alzheimer’s and Parkinson’s, according to the researchers, who published their study “Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain” in Nano Letters.

ICYMI - five outstanding studies in biomedicine worth following: #1 - Tracking cardiac disease - a new mesh bioelectronic system capable of tracking excitation-contraction dynamics, published in Nature #2 - Exploring remedies for Parkinson’s - Researchers treated a progressive PD mouse model, the MitoPark mouse, with a sustained release formulation of GLP-1R known as PT320, published in the Journal of Biomedical Science #3 - Developing decolonized medicine - For the case of joint pain in the Hai district of Tanzania, authors utilized a rapid ethnographic appraisal (REA) to characterize responses to joint pain, published in BMJ Global Health #4 - Marking the boundaries of melanoma - This study used 51 samples to compare the sensitivity of PRAME double-labeling in lengo maligna biopsies to the established single-labeling technique, published in the British Journal of Biomedical Science #5 - Using GPT for biomedicine - Authors developed a new learning paradigm that enables LLMs to perform NER tasks for biomedical texts, published in Bioinformatics out of Yale University

Celebrating Satyajit Mayor (Jitu) – Trailblazer in Cell Biology 🔬 Today, we’re spotlighting Dr. Satyajit Mayor, a groundbreaking cell biologist who has significantly advanced our understanding of cellular mechanisms and membrane biology! His contributions have not only shaped India’s place in the global cell biology community but have also transformed our understanding of how cells organize themselves to function precisely and adapt to their environment. The principal driving force of his laboratory is to uncover physicochemical rules that govern the local organization of the cell membrane and connect this to cellular and organismal physiology. 🔹 Pioneering Research on Cell Membranes: Dr. Mayor's work focuses on how cells regulate the molecules and pathways on their surfaces, particularly through the plasma membrane. His research on the organization of cell membranes challenged traditional views, showing that cell surfaces are far more dynamic and organized in clusters that assist in signaling and transport. 🔹 Unraveling Endocytosis: Endocytosis—the process by which cells absorb external material—is critical to cell communication, nutrient intake, and immune responses. Dr. Mayor’s research explored non-traditional pathways in endocytosis, revealing new insights into how cells interact with their environment and process information. 🔹 Impact and Honors: Currently, Dr. Mayor serves as the Director of the National Centre for Biological Sciences (NCBS) in Bengaluru. He is a recipient of several prestigious awards, including the Padma Shri, and is an elected fellow of the Indian Academy of Sciences and the Royal Society of London. 🔬 Dr. Mayor’s insights have implications for understanding cancer, infectious diseases, and immune responses, making him a true visionary in Indian biology. His work has inspired countless students and researchers to delve into the dynamic world of cellular biology, bridging biology and biophysics for a deeper understanding of life at the molecular level. Here’s to celebrating Dr. Satyajit Mayor—a scientist whose curiosity and innovation continue to push the boundaries of cellular biology! 🧬✨ #NCBS #Cellbiologist #IndianScientist #MembraneBiology #SatyajitMayor #throwbackthursday #spotlight #scientist #Awards #Thursday

Tomorrow, December 11, at 10.00 CET Ben Rombaut will defend his PhD thesis, titled: "𝘖𝘶𝘵-𝘰𝘧-𝘤𝘰𝘯𝘵𝘳𝘰𝘭 𝘔𝘪𝘤𝘳𝘰𝘨𝘭𝘪𝘢 𝘊𝘢𝘶𝘴𝘦 𝘊𝘰𝘨𝘯𝘪𝘵𝘪𝘷𝘦 𝘋𝘦𝘧𝘪𝘤𝘪𝘵𝘴 𝘛𝘩𝘳𝘰𝘶𝘨𝘩 𝘌𝘹𝘤𝘦𝘴𝘴𝘪𝘷𝘦 𝘚𝘺𝘯𝘢𝘱𝘵𝘪𝘤 𝘌𝘭𝘪𝘮𝘪𝘯𝘢𝘵𝘪𝘰𝘯 𝘪𝘯 𝘈𝘭𝘻𝘩𝘦𝘪𝘮𝘦𝘳’𝘴 𝘋𝘪𝘴𝘦𝘢𝘴𝘦" at Universiteit Maastricht. 𝗔 𝗗𝗼𝘂𝗯𝗹𝗲 𝗗𝗼𝗰𝘁𝗼𝗿𝗮𝗹 𝗗𝗲𝗴𝗿𝗲𝗲 𝗨𝗻𝗶𝘃𝗲𝗿𝘀𝗶𝘁𝗲𝗶𝘁 𝗛𝗮𝘀𝘀𝗲𝗹𝘁/𝘁𝗨𝗟 𝗲𝗻 𝗨𝗻𝗶𝘃𝗲𝗿𝘀𝗶𝘁𝗲𝗶𝘁 𝗠𝗮𝗮𝘀𝘁𝗿𝗶𝗰𝗵𝘁 𝗦𝘂𝗽𝗲𝗿𝘃𝗶𝘀𝗼𝗿𝘀: Prof. dr. Tim Vanmierlo, Universiteit Hasselt & Prof. dr. Daniel van den Hove, Maastricht University. 𝗖𝗼-𝗦𝘂𝗽𝗲𝗿𝘃𝗶𝘀𝗼𝗿𝘀: Prof. dr. Bert Brône, Universiteit Hasselt & Dr. Inez Wens, Maastricht University. The goal of the research discussed in this thesis was to gain a fundamental understanding of the role of phosphodiesterase (PDE) 4B in microglia, to prevent cognitive deficits in Alzheimer’s disease (AD). We aimed to shed light on both intrinsic and extrinsic regulation of PDE4B to influence various microglial processes. Intrinsic regulation was investigated through the use of knockout models of PDE4B and its chaperone Disrupted-in-Schizophrenia 1 (DISC1), while extrinsic regulation by PDE inhibitors, such as A33, represented the next step in targeting mechanisms that are dysregulated in AD. This thesis describes chapters combining literature search with research employing in vitro assays, combined with in vivo models. Join the live stream here: https://lnkd.in/eM7U65hU 𝗞𝗲𝘆𝘄𝗼𝗿𝗱𝘀: Microglia, Alzheimer, cognition, synapses

It is finished! On January 22nd at 11:00, I will be defending my PhD thesis titled: 𝗥𝗲-𝗰𝗿𝗲𝗮𝘁𝗶𝗻𝗴 𝘁𝗵𝗲 𝗵𝘂𝗺𝗮𝗻 𝗶𝗻𝘁𝗲𝘀𝘁𝗶𝗻𝗲 𝗮𝘁 𝗺𝗶𝗰𝗿𝗼𝘀𝗰𝗮𝗹𝗲 using induced pluripotent stem cells and organ-on-chip systems This work represents the development and characterization of mini intestines generated from cells isolated from urine. These models hold great potential for studying intestinal diseases and physiological processes, and testing novel drugs in a personalized and human-relevant way. The cover also has a personal touch: I painted it to represent the diversity and remarkable self-organization of intestinal epithelial cells within a microfluidic organ-on-chip system—forming folds that resemble the villi in our intestine. The thesis can be accessed online: https://lnkd.in/e36KhcEj (including propositions: https://lnkd.in/eyU9K5yU) The ceremony will be streamed live: https://lnkd.in/eQ3nEeKP

Focus on #stemcells #research with Bio-protocol! (Series3_Post7) https://lnkd.in/gFyusk2X A detailed protocol for the isolation and maintenance, of skeletal stem cells from the calvarial suture, with potent bone-generating capability at a single-cell level. Skeletal stem cells in the suture mesenchyme are crucial for calvarial development, maintenance, and repair; and exhibit long-term self-renewal, clonal expansion, and multipotency. Work by Takamitsu Maruyama, Hsiao-Man Ivy Yu, and Wei Hsu at University of Rochester Medical Center, Harvard Stem Cell Institute and The ADA Forsyth Institute. Follow Bio-protocol to stay updated on the latest advancements in life-science research.