Bioscience Today’s Post

A leading nanomedicine researcher at The University of Manchester has received a £1.3m grant to advance research on Alzheimer’s and glioblastoma https://lnkd.in/e35Rbz33

🔬 Lab Spotlight: Cellular Biophysics Lab, IIT Bombay 🔬 Today, we’re showcasing the cutting-edge research at the Cellular Biophysics Lab, IIT Bombay 🌟. Led by Prof. Dr. Shamik Sen, the lab explores the biophysical principles underlying cellular behaviors and mechanics! ✨ 🔬 Key Research Areas🔬 ◻ Cancer Metastasis: Investigating how the extracellular matrix (ECM) influences cancer cell motility and invasion. The lab examines how physical and chemical cues drive metastasis through tumor microenvironment interactions. 🧬🔍 ◻ Stem Cell Mechanobiology: Understanding how mechanical signals in the stem cell niche regulate embryonic stem cell (ESC) pluripotency. Insights from this work are applied to create synthetic substrates for ESC differentiation. 🌱🔬 ◻Tissue Engineering: Exploring how ECM properties, like stiffness and porosity, affect cell behavior. Biomaterials with tunable mechanics are utilized to mimic ECM features for engineering applications. 🧫🛠️ 🔗 Explore more of their groundbreaking work: Lab Homepage: https://lnkd.in/gsywHybW ✍🏻 Credits: 🎨 Poster: Abhilaya Makkuva 📝 Content: Md Rashid Alam #NGSF #Biophysics #IITBombay #CellularMechanics #ResearchInnovation

🌟 Ismaili Innovator Spotlight: Needa Brown 🌟 Meet Dr. Needa Brown, a trailblazing scientist and educator whose work in nanotechnology is transforming healthcare. As an Assistant Professor at the University of Central Florida and former Program Director of Nanomedicine at Northeastern University, Needa has been at the forefront of developing innovative nanomaterials that have the potential to revolutionize cancer treatment and biomedical imaging. Her research focuses on the design of nanoparticles to enhance the effectiveness of radiation therapy and immunotherapy, aiming to create more targeted, less invasive treatments for cancer. With numerous publications and awards to her name, including her work on nanoparticle-enhanced imaging for atherosclerosis and her development of novel cancer therapies, Needa continues to push the boundaries of what's possible in medical science. In addition to her groundbreaking research, Needa is deeply committed to mentorship and education, teaching the next generation of scientists and leading initiatives to integrate nanomedicine into medical practices. Dr. Needa (Virani) Brown is a shining example of how innovation in nanotechnology can lead to life-saving breakthroughs. Her work is a testament to the impact that science and technology can have on improving human health and well-being. #IsmailiInnovators #Nanomedicine #CancerResearch #Nanotechnology #STEM #Innovation #Leadership - 🔔 Follow Global Ismaili Innovators to see who we showcase next 🏆 Nominate an innovator to be featured at https://lnkd.in/g5uAAs4r

Research into exosomes has earned a group of Stevens faculty and students a cover story in the January 2025 edition of Advanced Sensor Research, the open access home for groundbreaking research on sensing materials, devices and their applications. Professor Hongjun Wang and five students published a paper titled "Noble Metal Nanoparticle-Based Aptasensors: A Powerful Tool for Exosomal Detection," which delves into the importance of exosomes as reliable early biomarkers for different diseases such as cancer, Parkinson's, Alzheimer's and more. Wang and the students represent the Department of Biomedical Engineering at Stevens and the Department of Chemistry and Chemical Biology at Stevens. Felicia Spadavecchia doubled as the cover designer and co-publisher. She was joined by: Jingyu Sun, Wei Hu, Nuo Xu and Jonathan Makris. Read the entire publication 👇 https://lnkd.in/euHCjq8Q Stevens Institute of Technology

Congrats to Professor Chad Mirkin for being the first Northwestern University scientist to win the 2024 Kavli Prize in Nanoscience! "Mirkin is recognized for his discovery of spherical nucleic acids (SNAs), nanostructures comprised of a nanoparticle core and a shell of radially distributed DNA or RNA strands. These globular forms of nucleic acids have become the cornerstones of the burgeoning fields of nanomedicine and colloidal crystal engineering with DNA. They allow scientists to construct new forms of matter using particle “atoms” as the basic building blocks and DNA “bonds” as particle interconnects, and they are the basis for powerful tools that allow researchers and clinicians to track and treat disease in new ways. In particular, SNAs have led to the development of fast, automated point-of-care medical diagnostic systems and new experimental drugs for treating many forms of cancer, neurological disorders, and diseases of the skin." https://lnkd.in/eru-whhw

I am happy to share our latest review article on "Recent advances in nanogels for drug delivery and biomedical applications" published in RSC Biomaterials Science (Impact factor: 5.8) in collaboration with Dr. Arti Vashist, Florida International University. This work dives into recent advances in nanogels, showcasing their ability to revolutionize targeted drug delivery and multifunctional therapeutic applications in cancer, neurological diseases, ophthalmology, wound healing, and infectious diseases like tuberculosis. Our review addresses the transformative role of nanogels in overcoming traditional treatment challenges—such as toxicity, drug resistance, and off-target effects—by integrating advanced therapeutics with imaging in a single, highly functionalized platform. We also explore their unique potential to respond to external stimuli like pH, temperature, and near-infrared light, enabling on-demand drug release and precision in treatment. This collaboration exemplifies the strength of cross-institutional partnerships between Florida International University and Bennett University. Together, we are advancing the promise of nanogels in modern healthcare by addressing stability, biocompatibility, and clinical translation. https://lnkd.in/gAuvn-wC Delve into the full article to see how nanogels could pave the way for safer, more effective therapies! #Research #Nanotechnology #Biomaterials #DrugDelivery #BiomedicalScience #AcademicCollaboration #CoENanosensorsandNanomedicine Centre for Excellence in Nanosensors and Nanomedicine (CoENN) at Bennett University. Ajith Abraham Latha Narayanan Biotechnology at Bennett Hitankshi Thukral

https://lnkd.in/d2WDuyR5 University of Pennsylvania School of Engineering and Applied Science engineers say they have modified lipid nanoparticles (LNPs) to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This breakthrough marks a significant step toward potential next-generation mRNA treatments for neurological diseases like Alzheimer’s and Parkinson’s, according to the researchers, who published their study “Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain” in Nano Letters.

A big collaborative effort of the whole #NOCI consortium (University of Twente, Leiden University Medical Center, UMCG, Hubrecht Institute, Developmental Biology and Stem Cell Research, Erasmus MC and Delft University of Technology) is now available in Nature Portfolio, specifically in Nature Biomedical Engineering. Special shoutout to the persons leading this initiative, our now Dr. Dennis Nahon and our PhD candidate Renée Moerkens! If you want to know more about novel methods and technologies that could improve or enable the quantification of physiological features in various types of #OoCs, don't miss the opportunity to check the paper in the link below! #NOCI #OOC #MPS #LUMC #UT #TUDelft #UMCG #EMC #Hubrecht

Congratulations to Massachusetts Institute of Technology faculty members Angela Belcher and Emery N. Brown, who were each presented with the National Medal of Science, and Paula Hammond Cunningham ’84, PhD ’93, and Feng Z., who were awarded the National Medal of Technology and Innovation. Hammond and Belcher are frequent collaborators, and each of them has had significant impact on the fields of nanotechnology and nanomedicine. “By harnessing the processes of nature, Angela’s innovations have impacted fields from energy to the environment to medicine. Her non-invasive imaging system has improved outcomes for patients diagnosed with many types of cancer," says Anantha Chandrakasan, dean of the MIT School of Engineering and chief innovation and strategy officer at MIT. "Paula’s pioneering research in nanotechnology helped transform the ways in which we deliver and administer drugs within the body — through her technique, therapeutics can be customized and sent directly to specifically targeted cells, including cancer cells.” Read the MIT News article: https://lnkd.in/eirfXTaY #faculty #awards #NationalMedals #nanoscience #nanotechnology #nanoscale #nanomedicine #chemicalengineering #biologicalengineering #materialsscience #engineering #science #technology #research