Disc Medicine’s Post

This recent study involving over 75,000 participants revealed that nearly 10% of individuals with MGUS have multiple paraproteins, with IgM being more common.  Findings indicate that different paraproteins reflect relatively independent underlying disease processes, but during the relatively short study follow-up, progression risk is similar for those with multiple and single paraproteins.  Read more about this study here 👉https://bit.ly/3OAqQxy #MGUS #paraprotein #hematology

Image of the Week! Submitted by: Luis F. Arias, M.D., Ph.D. Directory Profile: https://buff.ly/3UHLkYx Subspecialty: Medical renal Diagnosis: Diffuse podocytopathy (minimal change disease) with prominent microvillous transformation of podocyte cytoplasm #Pathology #PathologyOutlines #RenalPath

The answer to yesterday’s #ClinicalChallenge question is: False. Studies have evaluated whether a relationship exists between monoclonal gammopathy of undetermined significance (MGUS) and autoimmune diseases or immune-related conditions. Although several retrospective studies had suggested an increased risk of MGUS among patients with these conditions, a large Icelandic, prospective, population-based screening study did not find an association. The increased prevalence in prior retrospective studies likely reflects a sampling bias as testing was likely preferentially performed in patients with autoimmune diseases or immune-related conditions due to a perceived association. View the related What's New topic in #UpToDate: https://ow.ly/hcRE50Ts9Vw #hematology #meded

https://lnkd.in/gZSzymxu Article title: Clinical evaluation of children with celiac disease: A single-center experience   Author(s): Yasin Sahin   Journal: Archives of Clinical Gastroenterology   Journal ISSN: 2455-2283 Abstract   Background and objectives: The clinical findings of Celiac Disease (CD) change over time. Instead of classical symptoms such as diarrhea, growth retardation, abdominal bloating, atypical symptoms such as chronic constipation and abdominal pain may be the only sign of CD. In this study, we aimed to evaluate the clinical features of our patients with CD. #CeliacDisease #Children #IntestinalBiopsy #InflammatoryBowelDisease #FunctionalGIDisorders #GastrointestinalAndLiverDisease #DigestiveOncology #GastrointestinalSurgery #PediatricGastroenterology #ColorectalCancer #PancreaticCancer #HepatocellularCarcinoma #GastrointestinalBleeding #Endoscopy #Peertechz #PeertechzPublications #SurgicalGastroenterology #StomachUlcers #VirtualColonoscopy #GastricUlceration #RouxenYGastricBypass #GastricAcidSecretion #GastricMucosa #GastricUlcerHealing #GastricCardiaCancer #ReproductiveEndocrinology #EndocrineDisorders #Hepatology #AlimentaryCanal #PancreasCancer

https://lnkd.in/ghir3iWr Article title: Characterization of patients diagnosed with drug-induced liver injury   Author(s): Itay Ashkenazi; Yoav Lurie; Ariel Kenig; Shoshana Zevin; Ina Gafanovich; Elad Resnick; Shimon Shteingart; Tali Bdolach-Abram; David E Katz   Journal: Archives of Clinical Gastroenterology   Journal ISSN: 2455-2283 Abstract Introduction and Objectives: Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the USA, and a major cause of medication discontinuation. However, DILI is often under-diagnosed, primarily due to the lack of agreed upon diagnostic criteria and limiting coding nomenclature. Materials and methods: We conducted a retrospective observational analysis of demographic, clinical, and laboratory data for 55 patients hospitalized in an Israeli tertiary care medical center between 2005-2017 and diagnosed with DILI. #DrugInducedLiverInjury #Antibiotics #LiverFailure #InternationalClassificationOfDisease #DeRitisRatio #InflammatoryBowelDisease #FunctionalGIDisorders #GastrointestinalAndLiverDisease #DigestiveOncology #GastrointestinalSurgery #PediatricGastroenterology #ColorectalCancer #PancreaticCancer #HepatocellularCarcinoma #GastrointestinalBleeding #Endoscopy #Peertechz #PeertechzPublications #SurgicalGastroenterology #StomachUlcers #VirtualColonoscopy #GastricUlceration #RouxenYGastricBypass #GastricAcidSecretion #GastricMucosa #GastricUlcerHealing #GastricCardiaCancer #ReproductiveEndocrinology #EndocrineDisorders #Hepatology #AlimentaryCanal #PancreasCancer

At Ipsen, we are proud to share a special video podcast published in Athens Voice, where Gregorios Kaltsas, Professor of Internal Medicine and Endocrinology, and President of the GrNETs Patient Organization, discuss the challenges of diagnosis, patient experiences, and the importance of recognizing rare conditions like neuroendocrine tumors (NETs). Watch now https://lnkd.in/djuqM9et to discover what a zebra might have in common with a rare disease and learn more about NETs. #ipsengreece #rarediseases #NETs

https://lnkd.in/gFXTCZ2G Article title: Intestinal dysbiosis: definition, clinical implications, and proposed treatment protocol (Perrotta Protocol for Clinical Management of Intestinal Dysbiosis, PID) for the management and resolution of persistent or chronic dysbiosis   Author(s): Giulio Perrotta   Journal: Archives of Clinical Gastroenterology   Journal ISSN: 2455-2283 Abstract: The human intestinal Microbiota is considered the second brain, because of its implications and correlations in hundreds of functional and dysfunctional processes. Therefore, if knowing the Microbiome (and the Microbiota) is important from a neurobioimmunological point of view, on the other hand it is equally important to investigate the correlations between dysbiosis and the onset of specific physical and psychological diseases. This study focuses on the scientific literature on natural and integrative treatments for intestinal dysbiosis, in order to identify a protocol that has the lowest possible risk and the best possible results, both in the acute phase (for the resolution of symptoms or as a preventive function) and in the chronic phase (for the management of the morbid condition and its clinical consequences). #InflammatoryBowelDisease #FunctionalGIDisorders #GastrointestinalAndLiverDisease #DigestiveOncology #GastrointestinalSurgery #PediatricGastroenterology #ColorectalCancer #PancreaticCancer #HepatocellularCarcinoma #GastrointestinalBleeding #Endoscopy #Peertechz #PeertechzPublications #SurgicalGastroenterology #StomachUlcers #VirtualColonoscopy #GastricUlceration #RouxenYGastricBypass #GastricAcidSecretion #GastricMucosa #GastricUlcerHealing #GastricCardiaCancer #ReproductiveEndocrinology #EndocrineDisorders #Hepatology #AlimentaryCanal #PancreasCancer

https://lnkd.in/gRs7d22E Article title: Implementation and Implication of Ignoring Small Polyps at Colonoscopy   Author(s): Jana G Hashash; Ibrahim Hanouneh; Swaytha Ganesh; John Nasr; Robert E Schoen   Journal: Archives of Clinical Gastroenterology   Journal ISSN: 2455-2283 Introduction: Small (≤5mm) polyps are much more frequently encountered than medium (6-9mm) or large sized (≥10 mm) polyps. In a study of 4,967 patients undergoing colonoscopy, 1,025 polyps ≤5mm, 247 polyps between 6-9mm, and 89 polyps ≥10 mm in size were detected [11. Tsai FC, Strum WB (2011) Prevalence of advanced adenomas in small and diminutive colon polyps using direct measurement of size. Digestive diseases and sciences 56: 2384-2388.]. When a small polyp is found in conjunction with a larger polyp, the small polyp's impact on cost is less significant. Presuming that the medium or large sized polyp will be removed, the procedure will include a polypectomy. #DiminutivePolyp #CTColonography #Colonoscopy #Healthcare #MedicalScreening #Gastroenterology #PreventiveCare #DigestiveHealth #InflammatoryBowelDisease #FunctionalGIDisorders #GastrointestinalAndLiverDisease #DigestiveOncology #GastrointestinalSurgery #PediatricGastroenterology #ColorectalCancer #PancreaticCancer #HepatocellularCarcinoma #GastrointestinalBleeding #Endoscopy #SurgicalGastroenterology #StomachUlcers #VirtualColonoscopy #GastricUlceration #RouxenYGastricBypass #GastricAcidSecretion #GastricMucosa #GastricUlcerHealing #GastricCardiaCancer #ReproductiveEndocrinology #EndocrineDisorders #Hepatology #AlimentaryCanal #PancreasCancer

How does sickle cell anemia affect a person's life? Sickle cells that block blood flow to organs deprive the affected organs of blood and oxygen. In sickle cell anemia, blood also is low in oxygen. This lack of oxygen-rich blood can damage nerves and organs, including the kidneys, liver and spleen, and can be fatal. Splenic sequestration. September is National Sickle Cell Awareness Month, designated by Congress to help focus attention on the need for research and treatment of sickle cell disease. #Hematology #Sickle_cell_anemia

https://lnkd.in/g4GaFqun Article title: Predictive risk factors for liver abscess rupture: A prospective study of 138 cases   Author(s): Ndong A; Tendeng JN; Ndoye NA; Diao ML; Dieye A; Diallo AC; Mansouri MR; Dia DA; Nibogora J; Fall F; Sagna SA; Konta B; Kane K; Dieng M4; Diedhiou M4; Manyacka PM; Konaté   Journal: Archives of Clinical Gastroenterology   Journal ISSN: 2455-2283 Abstract   Introduction: Liver abscess is a serious condition due to its complications. The most frequent complication is rupture. Our aim is to determine the predictive risk factors of liver abscess rupture at the Saint Louis Regional Hospital Center.   Material and methods: This is a prospective descriptive and analytical study over the period of 1st January 2016 to 28th February 2019. We included liver abscess records regardless of age. An univariate and then multivariate analysis according to a Cox model allowed us to determine the factors associated with the occurrence of rupture. #Liver #Abscess #Pyogenic #Amoebic #Rupture #Peritonitis #InflammatoryBowelDisease #FunctionalGIDisorders #GastrointestinalAndLiverDisease #DigestiveOncology #GastrointestinalSurgery #PediatricGastroenterology #ColorectalCancer #PancreaticCancer #HepatocellularCarcinoma #GastrointestinalBleeding #Endoscopy #Peertechz #PeertechzPublications #SurgicalGastroenterology #StomachUlcers #VirtualColonoscopy #GastricUlceration #RouxenYGastricBypass #GastricAcidSecretion #GastricMucosa #GastricUlcerHealing #GastricCardiaCancer #ReproductiveEndocrinology #EndocrineDisorders #Hepatology #AlimentaryCanal #PancreasCancer