Centre of Bioinformatics Research and Technology (CBIRT)’s Post

Researchers at @IRBBarcelona introduce #PocketVec, a game-changing method to characterize druggable protein pockets. Using inverse virtual screening, PocketVec overcomes key limitations in drug discovery strategies! 💡 Using PocketVec, the team conducted a comprehensive human proteome analysis, identifying over 32,000 binding sites across 20,000 protein domains. This massive undertaking utilized both experimental structures and AlphaFold2 models. 🎯 The study's extensive similarity search, involving 1.2 billion pairwise comparisons, revealed previously undetected druggable pocket similarities. This breakthrough could revolutionize chemical probe development and expand our understanding of the druggable space. Quick Read: https://lnkd.in/gaZGyEQ8 #Bioinformatics #Proteomics #VirtualScreening #DrugDiscovery #AIinBiology #ScienceNews

🎯 Our Science at NUVISAN: Targeted Protein Degradation (TPD) Traditional drug discovery often revolves around inhibiting protein activity. Here at NUVISAN, we harness cellular machinery to drive protein degradation, advancing drug discovery! Our services include target-finding, degrader design, and synthesis. Explore the capabilities of our integrated TPD platform, leveraging advanced biophysical and biochemical techniques to identify and optimize leads. Additionally, our high-throughput cell-based assays swiftly identify cell-permeable compounds for protein degradation. 📧 Explore PROTAC and Molecular Glue technology with our captivating infographics: https://lnkd.in/djs8YDrY #OurScience #ProteinDegradation #PROTACTechnology #DrugDiscovery #InnovativeScience #TPD #MolecularGlue #theScienceCRO

The ability to accurately identify proteins is essential to exploring function, understanding impact to biological process, and uncovering disease mechanisms. Next-Generation Protein Sequencing™ with single-amino acid resolution offers the precision needed to avoid drawing inaccurate conclusions. Learn how you can utilize Quantum-Si's #Platinum® instrument for protein identification to support your research and drive scientific breakthroughs! Visit our enhanced Protein Identification page today! https://lnkd.in/gmWBq-nT #Proteomics #ProteinIdentification #QSI #Biotech #Research #NGPS

✨New Application Note to view!📄 Our Breakthrough With the eProtein Discovery System, we've conquered the challenges of expressing full-length transcription factor L - nicknamed TF L, a notoriously difficult to express protein with DNA binding (homeodomain) and LIM Domains and intrinsically disordered regions. By strategically employing solubility tags and optimizing cell-free blends, we've unlocked the secret to producing abundant soluble TF L protein. A Testament to Success We've taken this success a step further by validating the DNA binding function of purified TF L protein. This groundbreaking achievement not only addresses the long-standing limitations in TF L research but also paves the way for innovative therapeutic development. A New Era of Protein Science The eProtein Discovery System is more than just a tool; it's a game-changer. By empowering researchers to efficiently produce complex proteins, we're accelerating scientific discovery and bringing us closer to a future where protein-based therapies are a reality. 📰 Download now https://eprote.in/2lZkkwud #proteinaccess #transcriptionfactors #proteinexpression #proteinscience #proteinengineering #drugdiscovery #biotech

4️⃣ Today, we're excited to share insights into the crucial fourth step of our immunoassay development: Assay Setup and Optimization. 🔎 Once the foundation of core assay reagents is laid, our dedicated team springs into action to develop the assay in alignment with bioanalytical guidance documents. This stage is where precision and expertise converge to create assays of unparalleled accuracy and reliability. But what sets us apart? It's our groundbreaking AnySource® sample dilution technology that truly revolutionizes the game. With AnySource®, we have the flexibility to adapt assays to a myriad of matrices, whether it's animal, artificial, or human, as well as challenging matrices like CSF, synovial fluid, aqueous humor, and beyond. But we don't stop there. We're constantly pushing the boundaries to optimize every aspect of the assay. From fine-tuning required sample volumes for microsampling or rare matrix study support to enhancing selectivity and reducing background noise, we leave no stone unturned in our quest for perfection. Our unwavering commitment to excellence ensures that researchers and institutions can rely on our assays to deliver accurate and reproducible results, even in the most demanding of conditions. Join us as we continue to push the boundaries of science and empower researchers worldwide to make groundbreaking discoveries! #AssayDevelopment #Immunoassay #Science #Innovation #Research #Biotechnology #AnySource #SampleDilution #Optimization #Breakthroughs #Chimera #ChimeraBiotec

Last year, I got into the Research Program of #Genomac. Although it was laced with many challenges, the experience garnered is quite invaluable. The manuscript of the research project undertaken is presently being prepared for publication and I appreciate all my colleagues for the efforts in ensuring a soft landing. Special thanks to the #Genomac team as well. #Research #AntiCancerPeptides #MultiOmics

*** Paper alert *** Aviv Regev and her team from Genentech published a paper today in Nature. https://lnkd.in/dMNYF5k5 The paper describes the tool SCimilarity, a metric learning framework to learn a unified and interpretable representation that enables rapid queries of tens of millions of cell profiles from diverse studies for cells that are transcriptionally similar to an input cell profile or state. Myllia Biotechnology CSO Tilmann Burckstummer anticipates that this model will become useful to compare transcriptional profiles of different cell types and cell states: "At Myllia, we perform single-cell CRISPR screens at scale. We are often confronted with the problem that Dr. Regev has tackled here. Having framework for quantitative comparison of different cell populations will greatly facilitate the computational analysis of the large datasets we produce." www.myllia.com #mylliabio #singlecells #crisprcas9

SFBN Feed: Elegen Now Ships Plasmids Up to 15 kb in Just 10 Business Days, Bringing Unprecedented Speed to Long DNA Synthesis https://lnkd.in/gpJVGQGB SAN CARLOS, Calif.–(BUSINESS WIRE)– #CGT–Elegen, the leader in next-generation DNA manufacturing, today announced the launch of ENFINIA™ Plasmid DNA, a faster, cost-effective solution for clonal synthesis of long and complex genes. ENFINIA Plasmid DNA provides [...] #BayArea #SanFrancisco #Biotech #Lifescience #News

🚀 Just completed an intensive Molecular Docking Course at Biogrademy. Excited to leverage these advanced skills in molecular interactions and drug discovery. Onward and upward! #MolecularDocking #Biogrademy #Bioinformatics #Research

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