Vizgen

A recent study published in Cell Reports reveals an important connection between RNA localization and how cells migrate. Leveraging MERFISH technology, researchers from Yale University, National Cancer Institute (NCI), University of Colorado Boulder and Memorial Sloan Kettering Cancer Center, discovered that hundreds of mRNAs localize to focal adhesions (FAs). These FA-associated RNAs form complexes with G3BP1, a key RNA-binding protein, which regulates FA protein dynamics and ultimately, cell migration. This research adds a new layer to our understanding of gene regulation and could inform future studies in wound healing, cancer metastasis, and mechanobiology. In this study, MERFISH enabled: ➡️High-Resolution Spatial Mapping: Enabled precise visualization of FA-mRNAs within cells, confirming their localization at FAs. ➡️Transcriptome-Wide Insights: Identified and mapped hundreds of FA-enriched mRNAs, revealing their association with G3BP1 and FA proteins. ➡️Mechanistic Validation: Allowed researchers to study spatial gene expression changes in real time, demonstrating how FA-mRNAs interact with FA proteins. ➡️Cell Migration Research: Provided crucial evidence linking RNA localization, FA function, and cell motility, deepening our understanding of RNA-protein interactions in cytoskeletal dynamics. Read the full paper in Cell Reports: https://hubs.ly/Q03hq_0r0 #SpatialBiology #MERFISH

We’re Heading to AACR 2025! 🎉 We’re looking forward to attending the American Association for Cancer Research (AACR) Annual Meeting this year, where we’ll be sharing how our latest advancements are pushing the boundaries of spatial biology and multi-omics and empowering researchers to achieve breakthrough discoveries. What to Expect: ➡️Live demos of MERSCOPE® Ultra and detailed overview of MERFISH 2.0, showcasing enhanced sensitivity and FFPE compatibility ➡️An expansive menu of configurable ADC OmniVUE™ panels with validated biomarkers for accelerating ADC therapies ➡️An integrated spatial multi-omics experience, offering transcriptomics and proteomics for deeper insights into cancer biology ➡️Expert guidance on optimizing your spatial workflows with MERFISH 2.0 and InSituPlex® technologies Visit us at Booth 3219 to explore the new, expanded capabilities of Vizgen and pick up some fun booth prizes and giveaways! And we hope you’ll catch our presentations to dive deeper into our latest research. See you there! #AACR2025 #SpatialBiology #MultiOmics #Oncology

From cancer to neurodegenerative conditions, spatial biology is redefining how we study and potentially treat complex diseases. In a new article from The Pathologist, Vizgen’s Gourab Chatterjee and Lorenz Rognoni share how spatial image data science is giving researchers and pathologists unprecedented insights into tissue structure and cellular interactions, including how: ➡️Spatial biology delivers a high-resolution view of cell types, their locations, and interactions. ➡️Multiplexed imaging and AI-powered analytics enable deeper understanding of disease progression and treatment response. ➡️Machine learning is advancing pathology toward more objective, reproducible, and personalized diagnostics. Read the full article:  https://hubs.ly/Q03gGGCs0 #SpatialBiology #DigitalPathology

Unlock new dimensions in your spatial biology research. ✨ Why researchers are excited about MERSCOPE Ultra™: ➡️Expanded Imaging Area: Process up to 3 cm² of tissue on a single slide, accommodating larger or multiple samples in one run. ➡️Faster Speed: Achieve imaging speeds over twice as fast, accelerating your research workflow. ➡️Flexible Flow Cells: Choose between two flow cell sizes to optimize reagent use based on your sample size. With MERSCOPE Ultra, gain deeper insights into complex biology with unparalleled efficiency and precision. Learn more and download the brochure: https://hubs.ly/Q03gv2Fx0 #SpatialBiology #MERSCOPEUltra #Genomics #ResearchInnovation

We’re thrilled to welcome the Translational Genomics Research Institute (TGen) as a Vizgen Certified Service Provider! Based in Phoenix, AZ, TGen's Center for Spatial Multi-Omics (COSMO) is dedicated to transforming biomedical research through spatial biology. As a Certified Service Provider, TGen offers researchers the ability to: ➡️Map up to 960 custom RNA targets at subcellular resolution using the MERSCOPE® Ultra Platform. ➡️Apply Vizgen’s advanced spatial transcriptomics solutions across various samples, including complex tissues, to uncover new insights into disease mechanisms. ➡️Generate high-quality spatial data without the need for in-house technology infrastructure. TGen's recent launch of COSMO underscores their commitment to advancing spatial biology, providing researchers with unparalleled tools to visualize and map molecular data at the single-cell level within tissues. TGen has undergone rigorous training in Vizgen’s wet lab and data analysis workflows, ensuring best-in-class data quality and service. We’re proud to have them in our Certified Service Provider network, helping scientists push the boundaries of discovery. Learn more about TGen and our global Certified Service Provider network: https://hubs.ly/Q03fG5-H0 #SpatialBiology #MERSCOPE

Today, Vizgen is pleased to announce the resolution of litigation with 10x Genomics and Harvard University, enabling us to continue our global commercialization and the ongoing development of our transformative MERFISH technology. We are grateful to the scientific community for your continued support and collaboration. With this matter behind us, our focus is stronger than ever on serving researchers and driving progress in spatial multi-omics. Read the full statement from Vizgen CEO Rob Carson here: https://hubs.ly/Q03fKm250

New Insights into Aging Microglia with Spatial Transcriptomics ✨ A new pre-print study from researchers at Stanford University reveals how aging alters the function, morphology, and mRNA distribution of microglia. The study utilized MERFISH to analyze single-cell gene expression and morphology. By providing spatial context to gene expression data, the MERSCOPE® Platform enabled a deeper understanding of how microglia change with age. Key Findings: ➡️Subcellular mRNA localization: Aging disrupts transcript distribution within microglial processes, impacting functions like synaptic maintenance and migration. ➡️Morphological heterogeneity: Detected diverse microglial shapes within transcriptomically defined populations, including disease-associated microglia with unexpected morphologies. ➡️Functional shift with age: Aging shifts microglial functions from synaptic maintenance in younger brains to migration and catabolic pathways in older ones. This study highlights how the MERSCOPE Platform’s versatility extends beyond traditional models, providing high-resolution insights into how microglia evolve over time. Read the full pre-print: https://hubs.ly/Q03fC2lj0 #SpatialBiology #MERSCOPE #MERFISH

We're excited to partner with BioTuring to empower researchers with advanced tools to analyze high-resolution spatial genomics data. By integrating our MERSCOPE Ultra™ platform with BioTuring’s SpatialX deep learning platform for analyzing data, researchers gain streamlined access to deeper insights into cellular interactions and complex tissue architecture. This partnership brings researchers: ➡️Advanced Spatial Analysis: Combining MERSCOPE Ultra™'s high-quality spatial datasets with SpatialX’s powerful analytics simplifies the visualization and quantification of RNA transcripts in native tissue contexts. ➡️Deep Learning Capabilities: SpatialX enables cell clustering, cell type prediction, differential expression, and regional segmentation. ➡️Streamlined Data Workflow: This integrated solution transforms complex spatial genomics data into meaningful biological insights efficiently and effectively. Explore how Vizgen and BioTuring are working together to advance spatial biology research: https://hubs.ly/Q03fbnQ90 Interested in seeing it in action? Watch our webinar, "From Data to Discovery: Unlocking MERSCOPE Ultra™ Insights with SpatialX": https://hubs.ly/Q03fblnX0 #SpatialBiology #MERSCOPE

Spatial Spotlight #7 March is National Kidney Month, making it the perfect time to spotlight the complexity of the human kidney cortex through the lens of spatial transcriptomics. This MERSCOPE™ data image showcases the intricate filtering units called glomeruli and the different epithelial cells of the tubules, captured from an FFPE human kidney cortex sample. Transcripts from a 140-gene panel are displayed in the image including UMOD (green) and Synpatopodin (blue). By mapping gene expression within tissue architecture, MERSCOPE provides an unprecedented view of kidney biology, paving the way for deeper insights into renal function and disease. 📷 Image credit: Dr. Christoph Kuppe, RWTH Aachen University #SpatialSpotlight #NationalKidneyMonth #SpatialBiology #MERSCOPE

Reminder: Join Vizgen & Ultivue by Vizgen at NextGen Omics & Spatial Biology US 2025!  We’re looking forward to connecting with partners and scientists later this week in Boston to explore the future of spatial biology and demonstrate how spatial multi-omics is transforming cancer and infectious disease research. 📍Where to Find Us: Showcase: Table #8, Zone B, Spatial Biology US Presentation | Friday, March 28, 9:25 AM | Conference Room 4 Alex Genshaft, Product Manager at Vizgen will present “New Developments in Spatial Omics Unlock Insights into the Tumor Microenvironment.” Learn how: ➡️MERFISH 2.0 enhances RNA detection in FFPE cancer samples for deeper spatial insights in degraded tissues ➡️MERSCOPE® Ultra™ enables high-plex profiling of up to 1,000 genes in 3cm² tissues ➡️Combining MERFISH-based spatial transcriptomics with InSituPlex® proteomics enhances deep spatial immunophenotyping Panel Discussion | Friday, March 28, 11:35 AM | Conference Room 1 Gourab Chatterjee, Director of Product Strategy and Management at Vizgen, will join a panel discussion on “Multi-Omic Applications in Infectious Disease” to: ➡️Explore how spatial multi-omics can drive discoveries in vaccines & immunology ➡️Discuss new frontiers in multi-omic approaches to infectious disease research We hope you’ll join us for these insightful discussions on the next generation of spatial biology & multi-omics. Learn more & register:https://hubs.ly/Q03dBW6D0 #SpatialBiology #MultiOmics #Proteomics #Transcriptomics