We couldn't be more proud to serve our client California Cultured Inc. as they tackle one of the most critical steps in biomanufacturing: scaling from flask to bioreactor. We know how challenging this phase can be, and we're committed to providing the tools, software, and human expertise needed to optimize processes, enhance efficiency, and ensure scalability with confidence. Congratulations to the California Cultured team on this significant milestone!
🔬 Scaling Up: From Flask to Bioreactor 🌱 Last week, we took a critical step in scaling cell-cultured cocoa—moving from small-batch experiments to controlled precision fermentation at Pow.Bio This transition is where most biomanufacturing innovations face their biggest challenges, and we’re tackling them head-on. ✅ Process Optimization – From shake flasks to fully controlled bioreactors, we’re refining media formulations, oxygen transfer rates, and pH control to maximize cell density and metabolite production. ✅ Metabolic Efficiency – Cocoa cells are complex. We’re engineering conditions to enhance growth kinetics and drive flavonoid and lipid biosynthesis, essential for replicating the rich taste and mouthfeel of traditional chocolate. ✅ Cost-Effective Scale-Up – Fermentation at commercial volumes must be economically viable. We’re testing scalable feed strategies and continuous bioprocess monitoring to reduce cost per kilogram while maintaining high product consistency. With cocoa supply chains under pressure, precision fermentation offers a sustainable, deforestation-free, and ethically sourced alternative. This isn’t just an experiment—it’s the foundation of a new supply chain for chocolate. Next steps? Process validation, downstream processing optimization, and sensory trials. Scaling biotech is hard, but necessary. The future of chocolate depends on it. #Biomanufacturing #PrecisionFermentation #FoodTech #SyntheticBiology #CellCulturedChocolate #FutureOfFood #ScalingUp