Apoha

𝗪𝗵𝗮𝘁 𝗱𝗼𝗲𝘀 𝗶𝘁 𝙧𝙚𝙖𝙡𝙡𝙮 𝘁𝗮𝗸𝗲 𝘁𝗼 𝗯𝘂𝗶𝗹𝗱 𝗮 𝗱𝗲𝗲𝗽 𝘁𝗲𝗰𝗵 𝗰𝗼𝗺𝗽𝗮𝗻𝘆 𝗳𝗿𝗼𝗺 𝘁𝗵𝗲 𝗴𝗿𝗼𝘂𝗻𝗱 𝘂𝗽?   Last week, we welcomed 30+ future founders and scientists into our Apoha HQ for a rare behind-the-scenes look at what it means to translate frontier science into a thriving company.   We talked about how biology, physics, and computation converge in our work, from molecular interfaces to sensory intelligence and fluid-based computing, and gave an ultra-secret sneak peek at the Liquid Brain®.   But this wasn’t just a show-and-tell! We shared the lessons that don’t get written up in blog posts or pitch decks:  • How to be brave and take the leap from academia to entrepreneurship  • How to hold conviction in a novel, complex idea, especially when it’s early and hard to explain  • How to build something that’s scientifically rigorous and commercially focused Big thanks to the brilliant team at Fifty Years for bringing together such an ambitious group, and to every attendee who showed up with thoughtful questions and a founder’s mindset.   𝗪𝗲'𝗿𝗲 𝗲𝘅𝗰𝗶𝘁𝗲𝗱 𝘁𝗼 𝘀𝗲𝗲 𝘄𝗵𝗮𝘁 𝘆𝗼𝘂 𝗴𝗼 𝗼𝗻 𝘁𝗼 𝗯𝘂𝗶𝗹𝗱!   📸 A few snapshots from the day below!   #DeepTech #ScienceStartups #BiotechStartup #LiquidBrain #SensoryComputing #StealthScience

𝗕𝗶𝗴 𝗻𝗲𝘄𝘀: 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝗔𝗿𝗲 𝗡𝗼𝘄 𝗢𝗽𝗲𝗻 𝗳𝗼𝗿 𝗢𝘂𝗿 𝗙𝗶𝗿𝘀𝘁 𝗔𝗰𝗮𝗱𝗲𝗺𝗶𝗰 𝗚𝗿𝗮𝗻𝘁! Over the past few months, we have been working behind the scenes with a question in mind: 𝑊ℎ𝑎𝑡 𝑖𝑓 𝑚𝑜𝑟𝑒 𝑎𝑐𝑎𝑑𝑒𝑚𝑖𝑐 𝑟𝑒𝑠𝑒𝑎𝑟𝑐ℎ𝑒𝑟𝑠 𝑐𝑜𝑢𝑙𝑑 𝑒𝑥𝑝𝑙𝑜𝑟𝑒 𝑡ℎ𝑒 𝑘𝑖𝑛𝑑 𝑜𝑓 𝑏𝑖𝑜𝑝ℎ𝑦𝑠𝑖𝑐𝑎𝑙 𝑑𝑎𝑡𝑎 𝑡ℎ𝑎𝑡 𝐿𝑖𝑞𝑢𝑖𝑑 𝐵𝑟𝑎𝑖𝑛® 𝑐𝑎𝑛 𝑟𝑒𝑣𝑒𝑎𝑙? Today, we are opening our platform to the research community in a new way, with the launch of 𝗔𝗽𝗼𝗵𝗮’𝘀 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗔𝗰𝗰𝗲𝘀𝘀 𝗣𝗿𝗼𝗴𝗿𝗮𝗺. We are offering up to 𝟭𝟬 𝗗𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆 𝗚𝗿𝗮𝗻𝘁𝘀 (valued at up to £𝟭𝟬,𝟬𝟬𝟬 each in materials, data, and collaboration support) to researchers who want to explore molecular behaviour, functional interfaces, or build better computational methods using our Liquid Brain® system. If you are working with proteins, antibodies, lipids, or complex formulations, we would love to hear from you or someone in your lab who is always chasing interesting questions. 📅 Applications open 𝗠𝗮𝗿𝗰𝗵 𝟯𝟭𝘀𝘁, and we will be reviewing on 𝗮 𝗿𝗼𝗹𝗹𝗶𝗻𝗴 𝗯𝗮𝘀𝗶𝘀 - so get them in early! More details and how to apply here → https://lnkd.in/gUHX3jtT We are excited to learn together through these collaborations because we gain just as much insight as you. If this sparks an idea, come say hi 🙂 #AcademicResearch #OpenScience #Biophysics #Innovation #AI #Funding #Grants

What if you could predict antibody developability... in minutes, not months? Yeah, we thought that might catch your attention. We are really excited to be on the webinar with Sino Biological, Inc. that pushes the boundaries of what’s possible in biophysical screening!   🧠 On April 3rd, our CEO & Co-Founder, Shamit Shrivastava, will unveil Liquid Brain®—a radically different (and seriously effective) approach that combines physics, biology, and computing to get deep insights from just 10 µg Antibody Sample.   Here’s what we’ll dive into: How Liquid Brain® uses an excitable substrate to sense molecules (yes, it’s as cool as it sounds) Why standard assays miss the forest for the trees What we learned from screening 100+ clinical-stage antibodies, including spotting outliers early—without training data If you're into drug discovery, AI, biophysics, or just love the idea of smarter, faster science—this one's for you. 🗓 April 3rd, 2025 ⏰ 5PM BST / 9AM PST / 12PM EST 📍 Hosted by Sino Biological, Inc. 🎙 Speaker: Dr Shamit Shrivastava (CEO, Apoha)   Let’s turn your brain liquid (metaphorically, of course). 🔗 Event Page linked below in comments #Developability #AntibodyDevelopment #Biologics #DrugDiscovery #LiquidBrain #InMaterio #AIforBiology #BiophysicalScreening 

The Future of Agentic AI: Beyond Audio & Vision   Join us for “Agentic AI Builders and Founders Fireside Chat,” a DeepLearning.AI Pie and AI Event!   🗓 Date: Monday, March 24 📍 Location: IDEALondon, 69 Wilson St, London EC2A 2BB 🔗 Register here: https://lnkd.in/eF8x-vUi   The AI revolution is evolving fast, and multimodal Agentic AI is set to reshape how we build and interact with intelligent systems. At Pie & AI London – AI Hive Community Meetup, Shamit Shrivastava, Co-Founder & CEO of Apoha, will explore what’s next in Agentic AI beyond audio and vision—a space where AI learns, senses, and acts in truly novel ways. He’ll be joined by Chi Wang (Google DeepMind, creator of Autogen AG2), diving into AG2 and agentic AI design patterns, followed by a fireside chat on launching startups, commercialising research, and building open-source AI tools.   Organized with IDEALondon AI Hive Community aispymedia.com   💡 Let’s shape the future of AI, together. See you there!   #AgenticAI #AI #Startups #MachineLearning #AIHive #PieAndAI

How do you structure a team of scientists, experimentalists, ML researchers, data analysts, business developers & operators—each speaking their own (very specialized) language? Recently, we reshuffled how we work at Apoha, structuring our 17-person team into just two scrums. Our scrums are now (intentionally) larger than usual in agile methodology. This setup allows us to play to our strengths while driving adoption and better serving our customers. ⚡ Development: The problem-solvers. A multi-disciplinary team—physicists, hardware experts, experimentalists, software engineers, data scientists, and ML researchers—collaborating to develop and advance our innovation! 🚀 Validation: The strategists & executors. This team runs full throttle to explore the market landscape, engage with & deliver for our customers. All while ensuring that the Liquid Brain is making an impact where it matters most! Why the change? Because in deep tech, iteration speed is everything. Start-ups don’t have time to build for the sake of building. Every decision—every feature, experiment, and model—needs to bridge the gap between innovation and real-world application. Side projects? Plentiful. Staying focused? Non-negotiable. (Unless you’re #DeepSeek, of course 😏) 💡What have you learned about turning brilliant minds into a high-performing team? Let’s hear it! #AgileScience #Scrum #DeepTechStartup

🤔 If AI/ML really works, why can’t we just feed literature to ChatGPT and get perfect antibody sequences? This was one of the many questions I grappled with at the "Biologic" conference. It inspired me to write a conversation starter for anyone curious about how AI/ML and physics-based approaches fit into modern biology—especially for those unsure where to begin. 🎯 🌟 What’s inside: How sequence-structure-function maps onto AI/ML and physics. How LLMs, when applied to proteins, learn weak interactions like tracking subplots in a story. Why AI/ML is a powerful interpolator but still needs physics-based rigor and thoughtful experiments. How blending AI/ML and physics creates a more predictive and integrative future for biology. If you’re interested in adopting these tools but don’t know where to start, this orientation might be for you. Let’s unpack the magic together! #biologicsummit #thermodynamics #biophysics #ProteinLLMs

Kicking off 2025 with a Bang! 🚀 No slow start for us—the Apoha team began the year on the West Coast, staying close to our users and diving deep into their challenges and opportunities. Looking back at 2024, it’s hard not to feel proud of how far we've come. Just a few years ago, in 2021, Apoha was seen as a cool science experiment with one big question: Would it actually work? Fast forward to today—Liquid Brain® isn’t just working; it’s beating state-of-the-art assays and changing the way drug discovery is done. Scientists can now see the full behavioral blueprint of molecules—dimensions they’ve never been able to access before. 2024 was a year of milestones, growth, and validation. Our team grew by over 50%, yet the culture remained as vibrant as ever—good food, laughter, and, of course, karaoke featuring songs from around the world while ending the year with a whiskey tasting hackathon involving the liquid brain! But beyond the celebrations, 2024 was all about proving what Liquid Brain® can do. Here’s what we set out to achieve—and what we’re proud to have accomplished: 1️⃣ Can we unlock insights beyond what today’s technologies can achieve? ✅ Yes! Liquid Brain® generates novel, multi-dimensional, high-value data that reveals molecular details never seen before, improving predictive accuracy like never before. 2️⃣ Can we make this breakthrough scalable and reliable? ✅ Mission accomplished. Liquid Brain® is now fully automated, delivering high-quality data at an unprecedented scale. 3️⃣ Can Liquid Brain® make life easier for scientists? ✅ Absolutely! With just tiny amounts of material, scientists get actionable insights faster—no more guesswork, no more months of trial and error. We also had an amazing response to our recent talk in San Diego, where our CEO Shamit Shrivastava revealed our benchmark results, and the excitement was palpable! The Apoha booth was once again one of the busiest spots at the conference, with scientists eager to see what Liquid Brain® can do for them. And there’s more! 🎉 We wrapped up the year on a high note by winning two additional grants from Innovate UK for Antibodies and Lipid Nanoparticles, further fueling our mission to transform drug discovery. We also kicked off an exciting collaboration with Ethris (with Christian Plank, Estelle Beguin, PhD, Christian Dohmen) to advance LNP-based drug delivery. So, what’s next? 2025 is all about taking Liquid Brain® to new places (literally) and unlocking even more possibilities. Exciting things are on the horizon, and we can't wait to share more. 🥂 A huge thank you to our team, our partners, and everyone who’s been part of this journey. 2025 will be one for the books! If you’re working on designing new proteins, drugs, fats, or formulations—let’s chat. We would love to explore how Liquid Brain® can help. Drop our founders Anshika Srivastava or Shamit Shrivastava a message! #LiquidBrain #Apoha #NewYearNewPossibilities #Biotech #DeepTech #ExcitingTimes #Innovation

Sequence. Structure…State. We’re thrilled to sponsor the inaugural #BioLogicSummit in San Diego next week! 🚀 The world of protein modelling has long relied on sequence and structure, but one critical element has been missing: state. At Apoha, we’re not just analysing molecules—we’re decoding their hidden biophysical state, the foundation for truly understanding molecular behaviour. These state diagram embeddings provide the missing link to ground protein models in physical reality, unlocking a new frontier in prediction and optimization. Join us to explore how the Liquid Brain® can help you overcome the limitations of traditional datasets: ✅ Access novel, reference-quality datasets ✅ Generate biophysical insights of your material with just 10μg ✅ Optimize your models with state data designed for machine learning ✅ Play with clinical antibodies data on #HuggingFace If you’re attending BioLogic Summit, we’d love for you to experience the Liquid Brain® first-hand and see how we’re redefining biophysical insights for better predictions. 🧠 Attend Our Talk - By CEO Shamit Shrivastava “State Diagram Embeddings to Ground Protein Models in Physical Reality: Single Shot Biophysical Classification of Antibodies” 🗓️ Thursday 16th, 12:40 PM 🧠 Visit us at Booth #212 Meet our founders and team, engage with our data, and see how the Liquid Brain® measures up to the predictive power of 12 established assays combined. Anshika Srivastava, Shamit Shrivastava, Alec Thomas, Pratik Kotkar, Alex S., Natesh Ganesh #LiquidBrain #NaturalComputing #AI #ML #Biophysics #AntibodyDiscovery #LucassenWaves #PepTalk

🏆 Congratulations to Intel Ignite London alumni Anshika Srivastava, Co-founder & COO of Apoha, and Rosalyn Moran, Co-founder and CEO of Stanhope AI, who are on the Founders Forum Group 𝟭𝟬𝟬 𝗪𝗼𝗺𝗲𝗻 𝗙𝗼𝘂𝗻𝗱𝗲𝗿𝘀 𝘁𝗼 𝗪𝗮𝘁𝗰𝗵! The list features the most promising women tech founders to watch, operating across the UK and Europe, USA, and Southeast Asia, pre-Seed to Series A. We are so proud of these exceptional female founders and can’t wait to see what’s in store for them and their disruptive startups! 🔥 Check out the full list here https://lnkd.in/eaN_D6Jb #IntelIgnite #IAmIntel #WomenFounders #Startups

Looking for highly talented and motivated individuals to work closely on the some of the most cutting edge technologies and participate in product testing and business development. Stop by our booth and learn more if you are in the Oxford area.