SGLT2 HYPE project

📢 Prof. Ingo Eitel on the Mission Behind SGLT2 HYPE project! Prof. Dr. Ingo Eitel Eitel, Director of the Department of Internal Medicine II at #UKSH, Campus Lübeck, and principal investigator of the SGLT2 HYPE project study, shares a powerful perspective on the project’s impact: 🗣️ “𝗧𝗵𝗲 𝗦𝗚𝗟𝗧𝟮 𝗛𝗬𝗣𝗘 𝘀𝘁𝘂𝗱𝘆 𝗼𝗳𝗳𝗲𝗿𝘀 𝗮 𝘂𝗻𝗶𝗾𝘂𝗲 𝗼𝗽𝗽𝗼𝗿𝘁𝘂𝗻𝗶𝘁𝘆 𝘁𝗼 𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗲 𝗻𝗲𝘄, 𝗲𝘃𝗶𝗱𝗲𝗻𝗰𝗲-𝗯𝗮𝘀𝗲𝗱 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗳𝗼𝗿 𝗵𝘆𝗽𝗲𝗿𝘁𝗲𝗻𝘀𝗶𝗼𝗻 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁. 𝗜𝘁 𝗵𝗮𝘀 𝘁𝗵𝗲 𝗽𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝘁𝗼 𝗽𝗿𝗼𝘃𝗶𝗱𝗲 𝗺𝗶𝗹𝗹𝗶𝗼𝗻𝘀 𝗼𝗳 𝗽𝗮𝘁𝗶𝗲𝗻𝘁𝘀 𝘄𝗶𝘁𝗵 𝗮 𝘀𝗮𝗳𝗲𝗿 𝗮𝗻𝗱 𝗺𝗼𝗿𝗲 𝗲𝗳𝗳𝗲𝗰𝘁𝗶𝘃𝗲 𝘁𝗵𝗲𝗿𝗮𝗽𝘆.” The SGLT2 HYPE project is driving forward innovation in #cardiovascularHealth, aiming to redefine how we treat #hypertension — with real benefits for patients worldwide. 🌍💊 #ClinicalTrials #Innovation #HorizonEU European Health and Digital Executive Agency (HaDEA) European Commission Universitätsklinikum Schleswig-Holstein ARTTIC Innovation Medizinische Universität Innsbruck INSERM INSERM Institut national de la santé et de la recherche médicale Universidade do Porto Stiftung Institut für Herzinfarktforschung Quirónsalud Všeobecná fakultní nemocnice v Praze Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V. (DGK) Deutsche Herzstiftung e.V. @IRCCS Policlinico di Sant’Orsola - Azienda Ospedaliero Universitaria di Bologna VUL Santaros klinikos GPRI - General Practitioners Research Institute Bogomolets National Medical University @UniversityofGlasgow

🩺 #Hypertension: 𝗧𝗵𝗲 𝗦𝗶𝗹𝗲𝗻𝘁 𝗞𝗶𝗹𝗹𝗲𝗿 𝗪𝗲 𝗖𝗮𝗻’𝘁 𝗜𝗴𝗻𝗼𝗿𝗲 High blood pressure—also known as arterial hypertension—is one of the most dangerous and widespread health conditions in the world, yet 𝗺𝗼𝘀𝘁 𝗽𝗲𝗼𝗽𝗹𝗲 𝗱𝗼𝗻’𝘁 𝗲𝘃𝗲𝗻 𝗸𝗻𝗼𝘄 𝘁𝗵𝗲𝘆 𝗵𝗮𝘃𝗲 𝗶𝘁. 💡 It occurs when the force of blood against the artery walls is consistently too high, making the heart work harder to pump blood through the body. 💥 Over time, this silent strain can lead to serious health problems, including: ❤️🔥 𝗖𝗮𝗿𝗱𝗶𝗼𝘃𝗮𝘀𝗰𝘂𝗹𝗮𝗿 𝗱𝗶𝘀𝗲𝗮𝘀𝗲 🧠 𝗦𝘁𝗿𝗼𝗸𝗲 & 𝗰𝗼𝗴𝗻𝗶𝘁𝗶𝘃𝗲 𝗱𝗲𝗰𝗹𝗶𝗻𝗲 🧂 𝗖𝗵𝗿𝗼𝗻𝗶𝗰 𝗸𝗶𝗱𝗻𝗲𝘆 𝗱𝗶𝘀𝗲𝗮𝘀𝗲 (𝗖𝗞𝗗) ⬇️ 𝗥𝗲𝗱𝘂𝗰𝗲𝗱 𝗾𝘂𝗮𝗹𝗶𝘁𝘆 𝗼𝗳 𝗹𝗶𝗳𝗲 💔 Often symptomless, 𝗵𝘆𝗽𝗲𝗿𝘁𝗲𝗻𝘀𝗶𝗼𝗻 𝗾𝘂𝗶𝗲𝘁𝗹𝘆 𝗱𝗮𝗺𝗮𝗴𝗲𝘀 𝘁𝗵𝗲 𝗯𝗼𝗱𝘆 and is a leading cause of disability and early death—especially as we age. 🧪 𝗧𝗵𝗲 𝗦𝗚𝗟𝗧𝟮 𝗛𝗬𝗣𝗘 𝗽𝗿𝗼𝗷𝗲𝗰𝘁 𝗶𝘀 𝗼𝗻 𝗮 𝗺𝗶𝘀𝘀𝗶𝗼𝗻 𝘁𝗼 𝗰𝗵𝗮𝗻𝗴𝗲 𝘁𝗵𝗮𝘁. We’re working on 𝗶𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝘃𝗲 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁𝘀 using 𝗦𝗚𝗟𝗧𝟮 𝗶𝗻𝗵𝗶𝗯𝗶𝘁𝗼𝗿𝘀 to fight resistant hypertension—a form of high blood pressure that doesn’t respond well to standard therapies. Our goal? To 𝗶𝗺𝗽𝗿𝗼𝘃𝗲 𝗵𝗲𝗮𝗹𝘁𝗵 𝗼𝘂𝘁𝗰𝗼𝗺𝗲𝘀 𝗮𝗻𝗱 𝗾𝘂𝗮𝗹𝗶𝘁𝘆 of life for patients across Europe and beyond. 👉 𝗙𝗼𝗹𝗹𝗼𝘄 𝘂𝘀 to learn more about how we’re tackling this hidden epidemic. #Hypertension #CardiovascularHealth #ClinicalTrials #Innovation #HorizonEU European Health and Digital Executive Agency (HaDEA) European Commission Universitätsklinikum Schleswig-Holstein ARTTIC Innovation Medizinische Universität Innsbruck INSERM INSERM Institut national de la santé et de la recherche médicale Universidade do Porto Stiftung Institut für Herzinfarktforschung Quirónsalud Všeobecná fakultní nemocnice v Praze Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V. (DGK) Deutsche Herzstiftung e.V. @IRCCS Policlinico di Sant’Orsola - Azienda Ospedaliero Universitaria di Bologna VUL Santaros klinikos GPRI - General Practitioners Research Institute Bogomolets National Medical University @UniversityofGlasgow

🔬 𝗧𝗵𝗲 𝗩𝗶𝘀𝗶𝗼𝗻 𝗼𝗳 𝗦𝗚𝗟𝗧𝟮-𝗛𝗬𝗣𝗘: 𝗧𝗿𝗮𝗻𝘀𝗳𝗼𝗿𝗺𝗶𝗻𝗴 𝗛𝘆𝗽𝗲𝗿𝘁𝗲𝗻𝘀𝗶𝗼𝗻 𝗖𝗮𝗿𝗲! The 𝘃𝗶𝘀𝗶𝗼𝗻 𝗼𝗳 𝗦𝗚𝗟𝗧𝟮-𝗛𝗬𝗣𝗘 is to revolutionize how hypertension is treated by generating robust evidence on the long-term cardiovascular and kidney benefits of SGLT2 inhibitors, particularly Dapagliflozin. The project aims to deliver: 🔹 𝗔 𝗻𝗲𝘄 𝘀𝘁𝗮𝗻𝗱𝗮𝗿𝗱 𝗶𝗻 𝘁𝗵𝗲𝗿𝗮𝗽𝘆 – Incorporating SGLT2 inhibitors into routine hypertension treatment to not only lower blood pressure but also prevent heart failure, kidney disease and arterial stiffness. 🔹 𝗜𝗺𝗽𝗿𝗼𝘃𝗲𝗱 𝗽𝗮𝘁𝗶𝗲𝗻𝘁 𝗼𝘂𝘁𝗰𝗼𝗺𝗲𝘀 – Reducing the risks of stroke, heart attack, and renal failure, ultimately enhancing quality of life for millions living with hypertension. 🔹 𝗖𝗼𝘀𝘁-𝗲𝗳𝗳𝗲𝗰𝘁𝗶𝘃𝗲 𝗵𝗲𝗮𝗹𝘁𝗵𝗰𝗮𝗿𝗲 – Saving up to €10 billion annually across European healthcare systems by reducing complications and hospital stays. 🔹 𝗣𝗲𝗿𝘀𝗼𝗻𝗮𝗹𝗶𝘇𝗲𝗱 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝘀𝘁𝗿𝗮𝘁𝗲𝗴𝗶𝗲𝘀 – Tailoring therapies to better serve diverse patient groups, especially older adults and those with added cardiovascular risks. 🔹  𝗔 𝗵𝗲𝗮𝗹𝘁𝗵𝗶𝗲𝗿 𝗳𝘂𝘁𝘂𝗿𝗲 𝗳𝗼𝗿 𝗺𝗶𝗹𝗹𝗶𝗼𝗻𝘀 – Potentially 𝟮𝟱𝟬,𝟬𝟬𝟬 𝗽𝗿𝗲𝗺𝗮𝘁𝘂𝗿𝗲 𝗱𝗲𝗮𝘁𝗵𝘀 𝗲𝘃𝗲𝗿𝘆 𝘆𝗲𝗮𝗿 every year through better hypertension management. By bridging research with real-world clinical practice, SGLT2-HYPE is paving the way for more effective, personalized, and life-saving hypertension care. #Hypertension #CardiovascularHealth #ClinicalTrials #Innovation #HorizonEU European Health and Digital Executive Agency (HaDEA) European Commission Universitätsklinikum Schleswig-Holstein ARTTIC Innovation Medizinische Universität Innsbruck INSERM INSERM Institut national de la santé et de la recherche médicale Universidade do Porto Stiftung Institut für Herzinfarktforschung Quirónsalud Všeobecná fakultní nemocnice v Praze Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V. (DGK) Deutsche Herzstiftung e.V. @IRCCS Policlinico di Sant’Orsola - Azienda Ospedaliero Universitaria di Bologna VUL Santaros klinikos GPRI - General Practitioners Research Institute Bogomolets National Medical University @UniversityofGlasgow

🔬 𝗦𝗚𝗟𝗧𝟮 𝗛𝗬𝗣𝗘 𝗮𝘁 𝗨𝗞𝗦𝗛 𝗛𝗲𝗮𝗹𝘁𝗵 𝗙𝗼𝗿𝘂𝗺: “𝗨𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱𝗶𝗻𝗴 𝗛𝘆𝗽𝗲𝗿𝘁𝗲𝗻𝘀𝗶𝗼𝗻 – 𝗧𝗵𝗲 𝗦𝗶𝗹𝗲𝗻𝘁 𝗞𝗶𝗹𝗹𝗲𝗿”  🫀 As part of the #𝗨𝗞𝗦𝗛 𝗛𝗲𝗮𝗹𝘁𝗵 𝗙𝗼𝗿𝘂𝗺, , the event “𝗨𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱𝗶𝗻𝗴 𝗛𝘆𝗽𝗲𝗿𝘁𝗲𝗻𝘀𝗶𝗼𝗻 – 𝗧𝗵𝗲 𝗦𝗶𝗹𝗲𝗻𝘁 𝗞𝗶𝗹𝗹𝗲𝗿” provided valuable insights into the risks, prevention, and treatment of high blood pressure. Dr. Elias Rawish explained modern therapies and future research directions, including the SGLT2 HYPE project. The patients showed great interest not only in #hypertension but also in the promising outlook of the SGLT2 HYPE project! 📌 More about the event: https://shorturl.at/ISbhh #Hypertension #CardiovascularHealth #ClinicalTrials #Innovation #HorizonEU European Health and Digital Executive Agency (HaDEA) European Commission Universitätsklinikum Schleswig-Holstein ARTTIC Innovation Medizinische Universität Innsbruck INSERM INSERM Institut national de la santé et de la recherche médicale Universidade do Porto Stiftung Institut für Herzinfarktforschung Quirónsalud Všeobecná fakultní nemocnice v Praze Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V. (DGK) Deutsche Herzstiftung e.V. @IRCCS Policlinico di Sant’Orsola - Azienda Ospedaliero Universitaria di Bologna VUL Santaros klinikos GPRI - General Practitioners Research Institute Bogomolets National Medical University @UniversityofGlasgow

🔬 Mission of the SGLT2 HYPE project! #Hypertension is the leading preventable cause of premature death, affecting millions and significantly increasing the risk of #cardiovasculardisease, kidney failure, and cognitive decline. Yet, despite existing treatments, #Bloodpressure control remains inadequate, leaving patients at risk of severe complications. 🚀 The mission of SGLT2-HYPE is to redefine hypertension treatment by investigating the potential of #SGLT2 inhibitors (#SGLT2i) as an innovative therapeutic approach. Through a large-scale, randomized, placebo-controlled clinical trial, we aim to: ✅ Assess the cardiovascular and renal benefits of SGLT2i when added to standard antihypertensive treatment. ✅ Reduce the incidence of major adverse cardiovascular events (MACE+), including stroke, heart failure, and kidney disease. ✅ Empower patients and healthcare professionals with new, effective treatment strategies. ✅ Ensure inclusivity by considering socio-economic factors, sex-based differences, and patient-reported outcomes. With over 3,000 participants involved in multicenter trials across Europe, the project is advancing scientific research through collaborative efforts to improve lives and set new standards for hypertension management #CardiovascularHealth #ClinicalTrials #Innovation #HorizonEU European Health and Digital Executive Agency (HaDEA) European Commission Universitätsklinikum Schleswig-Holstein ARTTIC Innovation Medizinische Universität Innsbruck INSERM INSERM Institut national de la santé et de la recherche médicale Universidade do Porto Stiftung Institut für Herzinfarktforschung Quirónsalud Všeobecná fakultní nemocnice v Praze Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V. (DGK) Deutsche Herzstiftung e.V. @IRCCS Policlinico di Sant’Orsola - Azienda Ospedaliero Universitaria di Bologna VUL Santaros klinikos GPRI - General Practitioners Research Institute Bogomolets National Medical University @UniversityofGlasgow

Day 2 of the #SGLT2HYPE_GA25 Kick-Off Meeting has come to a close—and what an inspiring beginning to our journey! Over the past two days, we’ve defined key research goals, shared forward-thinking approaches to #Hypertension #treatment, and laid the foundation for the work ahead. 🚀 A big thank you to all participants—on site and online—for your energy and contributions. Let’s move ahead together and create real impact! 💪 #Hypertension #CardiovascularHealth #ClinicalTrials #Innovation #HorizonEU European Health and Digital Executive Agency (HaDEA) European Commission University Hospital Schleswig-Holstein (UKSH) ARTTIC Innovation Medizinische Universität Innsbruck INSERM Institut national de la santé et de la recherche médicale Universidade do Porto Stiftung Institut für Herzinfarktforschung Quirónsalud Všeobecná fakultní nemocnice v Praze Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V. (DGK) Deutsche Herzstiftung e.V. @IRCCS Policlinico di Sant’Orsola - Azienda Ospedaliero Universitaria di Bologna VUL Santaros klinikos GPRI - General Practitioners Research Institute Bogomolets National Medical University Prof. Dr. Ingo Eitel. Dr. Elias Rawish Roza Saraei Sebastian Reinstadler Jan Bělohlávek Borja Ibanez Kerstin Kacmaz Martin Vestweber Christine Dehn Luciano Potena Rokas Serpytis Janwillem Kocks Janina Stepinska Stéphanie GROJEAN Nicolas GIRERD Dr. Monika Maaß Melanie Carevic-Neri

🔹 Now presenting at the #SGLT2HYPE_25 Kick-Off: WP12f, led by Prof. Borja Ibanez from @Instituto Investigacion Sanitaria Fundacion Jimenez Diaz! 🎤 WP12f focuses on integrating key #HealthcareStakeholders—including professional societies, HTA bodies, and patient organizations—into the study design and execution. By actively involving these groups, the project ensures its relevance to clinical guidelines, daily medical practice, and health policy from the very beginning. 🔄 A dynamic feedback loop with stakeholders throughout the trial helps refine protocols, aligning research with real-world clinical and patient needs. Additionally, WP12f promotes the use and exploitation of project results, working towards meaningful improvements in hypertension treatment guidelines and sustainable healthcare policies. 🤝 Effective stakeholder engagement and strategic result exploitation are crucial to ensuring that scientific advancements lead to real-world impact—improving patient care and shaping better healthcare systems.. #Health #Hypertension #SGLT2 #CardiovascularHealth #HorizonEU #ClinicalResearch European Health and Digital Executive Agency (HaDEA) European Commission University Hospital Schleswig-Holstein (UKSH) ARTTIC Innovation Medizinische Universität Innsbruck INSERM Institut national de la santé et de la recherche médicale Universidade do Porto Stiftung Institut für Herzinfarktforschung Quirónsalud Všeobecná fakultní nemocnice v Praze Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V. (DGK) Deutsche Herzstiftung e.V. @IRCCS Policlinico di Sant’Orsola - Azienda Ospedaliero Universitaria di Bologna VUL Santaros klinikos GPRI - General Practitioners Research Institute Bogomolets National Medical University Prof. Dr. Ingo Eitel. Dr. Elias Rawish Roza Saraei Sebastian Reinstadler Jan Bělohlávek Borja Ibanez Kerstin Kacmaz Martin Vestweber Christine Dehn Luciano Potena Rokas Serpytis Janwillem Kocks Janina Stepinska Stéphanie GROJEAN Nicolas GIRERD Dr. Monika Maaß Melanie Carevic-Neri

Now on stage: Prof. Alexander Kuhlmann from #UniLübeck presenting WP9: #CostEffectiveness & #HealthEconomicAnalysis 📉🏥. Understanding the financial impact of SGLT2i treatment is crucial for making healthcare more sustainable. By analyzing how reducing major cardiovascular events affects healthcare costs, this work package helps shape future treatment strategies and improve patient access. #Hypertension, #CardiovascularHealth, #ClinicalTrials, #Innovation, #HorizonEU European Health and Digital Executive Agency (HaDEA) European Commission University Hospital Schleswig-Holstein (UKSH) ARTTIC Innovation Medizinische Universität Innsbruck INSERM Institut national de la santé et de la recherche médicale Universidade do Porto Stiftung Institut für Herzinfarktforschung Quirónsalud Všeobecná fakultní nemocnice v Praze Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V. (DGK) Deutsche Herzstiftung e.V. @IRCCS Policlinico di Sant’Orsola - Azienda Ospedaliero Universitaria di Bologna VUL Santaros klinikos GPRI - General Practitioners Research Institute Bogomolets National Medical University Prof. Dr. Ingo Eitel. Dr. Elias Rawish Roza Saraei Sebastian Reinstadler Jan Bělohlávek Borja Ibanez Kerstin Kacmaz Martin Vestweber Christine Dehn Luciano Potena Rokas Serpytis Janwillem Kocks Janina Stepinska Stéphanie GROJEAN Nicolas GIRERD Dr. Monika Maaß Melanie Carevic-Neri

🎤 Now presenting at the #SGLT2HYPE_GA25 Kick-Off: WP7: Monitoring , led by Dr. Roza Saraei & Stéphanie GROJEAN! 🏥 This work package ensures patient safety, smooth trial operations & high-quality data. WP7 establishes a monitoring system to track protocol adherence and quickly address any adverse events. ✅ Study sites are set up with all necessary approvals, staff & logistics, ensuring smooth operations and regular monitoring. 💾 Data integrity is a priority—WP7 maintains compliance with FAIR principles, operates the clinical trial database, and enables seamless DICOM data transfer for echocardiographic analysis. 🔍 With rigorous validation & monitoring, WP7 guarantees reliable data for impactful research! #Health #Hypertension #SGLT2 #CardiovascularHealth #HorizonEU #ClinicalResearch European Health and Digital Executive Agency (HaDEA) European Commission University Hospital Schleswig-Holstein (UKSH) ARTTIC Innovation Medizinische Universität Innsbruck INSERM Institut national de la santé et de la recherche médicale Universidade do Porto Stiftung Institut für Herzinfarktforschung Quirónsalud Všeobecná fakultní nemocnice v Praze Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V. (DGK) Deutsche Herzstiftung e.V. @IRCCS Policlinico di Sant’Orsola - Azienda Ospedaliero Universitaria di Bologna VUL Santaros klinikos GPRI - General Practitioners Research Institute Bogomolets National Medical University Prof. Dr. Ingo Eitel. Dr. Elias Rawish Roza Saraei Sebastian Reinstadler Jan Bělohlávek Borja Ibanez Kerstin Kacmaz Martin Vestweber Christine Dehn Luciano Potena Rokas Serpytis Janwillem Kocks Janina Stepinska Stéphanie GROJEAN Nicolas GIRERD Dr. Monika Maaß Melanie Carevic-Neri

We now continue with WP6f: Patient Enrollment, led by Dr. Elias Rawish from @UKSH! 🏥👨⚕️ 💡 Key objectives: ✅ Ensuring all clinical sites have the necessary resources to start patient enrollment. ✅ Establishing a reliable distribution strategy for investigational medicinal products (IMPs). ✅ Conducting regular patient visits to collect consistent data across all sites. ✅ Assessing cardiac function and structure in a subset of patients using echocardiographic analysis. Patient enrollment is a critical step in ensuring the success of #SGLT2HYPE, bringing us closer to new advancements in #hypertension #treatment! 🚀 #Hypertension, #CardiovascularHealth, #ClinicalTrials, #Innovation, #HorizonEU European Health and Digital Executive Agency (HaDEA) European Commission University Hospital Schleswig-Holstein (UKSH) ARTTIC Innovation Medizinische Universität Innsbruck INSERM Institut national de la santé et de la recherche médicale Universidade do Porto Stiftung Institut für Herzinfarktforschung Quirónsalud Všeobecná fakultní nemocnice v Praze Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V. (DGK) Deutsche Herzstiftung e.V. @IRCCS Policlinico di Sant’Orsola - Azienda Ospedaliero Universitaria di Bologna VUL Santaros klinikos GPRI - General Practitioners Research Institute Bogomolets National Medical University Prof. Dr. Ingo Eitel. Dr. Elias Rawish Roza Saraei Sebastian Reinstadler Jan Bělohlávek Borja Ibanez Kerstin Kacmaz Martin Vestweber Christine Dehn Luciano Potena Rokas Serpytis Janwillem Kocks Janina Stepinska Stéphanie GROJEAN Nicolas GIRERD Dr. Monika Maaß Melanie Carevic-Neri