PIRCHE

We are pleased to announce the release of a new version of PIRCHE’s TxPredictor software. Here’s what’s new: - Improved support for serological antigens throughout the platform. - Smarter B-cell epitope matching with updated configuration (Snow). - Now analyzing peptides across 13 loci. - Improved visualization features as part of RAMP, with common single antigen bead (SAB) specificities and locus-specific rankings now available. To learn more about how these features can benefit your program and support better decision-making, refer to our latest blog post in the app—or contact your PIRCHE sales representative, Jason Crumpton.

We are pleased to announce the release of a new version of PIRCHE’s TxPredictor software. Here’s what’s new: - Improved support for serological antigens throughout the platform. - Smarter B-cell epitope matching with updated configuration (Snow). - Now analyzing peptides across 13 loci. - Improved visualization features as part of RAMP, with common single antigen bead (SAB) specificities and locus-specific rankings now available. To learn more about how these features can benefit your program and support better decision-making, refer to our latest blog post in the app—or contact your PIRCHE sales representative, Jason Crumpton.

Our first PIRCHE product demo of the year will take place next week on March 26th. In this hour long demo, we'll be walking through the PIRCHE application and its different functions, as well as answering your questions about the PIRCHE technology and epitope matching: PIRCHE Product Demo (Q1) Date: March 26th 2025 Time: 5:00 PM (CET)/ 12:00 PM (ET) Wherever you are on your PIRCHE journey, you'll be sure to learn something new and interesting in this session. Register by using the link provided below. We're looking forward to seeing you then! Register here: https://lnkd.in/eJTyF-26

A game-changing study recently published in Frontiers in Immunology confirms that PIRCHE’s new algorithm for B-cell epitope mismatch (Snow) accurately predicts donor-specific HLA antibody (DSA) development.  Analyzing 843 kidney transplants, researchers found that patients with high Snow scores were twice as likely to develop DSAs. This risk increased when T-cell (PIRCHE-II) scores were also elevated. Better insights mean smarter donor selection and more effective transplant risk management. Pirche’s TxPredictor is the ONLY technology that evaluates both B- and T-cell mismatches, delivering comprehensive immune profiling and unmatched precision in immune risk assessment. This has the potential to truly transform the field of transplantation! To learn more, download the full press release about the study below. Full article: https://lnkd.in/eeTVCB_9 #Pirche #Transplantation #PrecisionMedicine #Innovation

Big changes are happening in the transplant world, and PIRCHE is ready to be part of the conversation! At this year’s #CEoT program, experts will tackle key policy shifts—including continuous distribution allocation policies and new federal data directives. We’re excited to showcase how our innovative HLA matching technology can help navigate these evolving challenges. Let’s shape the future of transplantation—together! See you in Scottsdale! #transplant #Pirche #CEoT #conference

Very excited to announce Pirche’s partnership with Devyser to advance the development of several new tests in their pipeline for stem cell and solid organ transplantation. The TxPredictor platform effectively predicts immunologic risk prior to transplant and may support more personalized decision-making related to biomarker monitoring for graft dysfunction. Pirche and Devyser have a shared commitment to improve patient outcomes and quality of life via novel technology. Through this partnership, we aim to bring the field closer to our collective aspiration of one graft for life. Thomas Klein Theis Kipling Jason Crumpton Heather Manion

Following on from our announcement yesterday, the full press release covering the groundbreaking new research article from our Chief Technology Officer, Matthias Niemann and colleagues is now available for you to read below. We can't overstate the significance of this landmark study of 400,000+ kidney transplant recipients which highlights the ability of innovative molecular matching technologies like Pirche’s Snow (B-cell) and PIRCHE-II (T-cell) to independently predict long-term graft survival. This is a major turning point in our mission to deliver longer-lasting transplants and a better quality of life to patients. Congratulations once again to everyone involved!

Exciting news in #transplantation! The latest research article by Matthias Niemann and colleagues, featured in Frontiers in Immunology, shows the correlation of PIRCHE and Snow scores with kidney graft survival. With over 400,000 cases, they demonstrated that applying multiple molecular HLA matching algorithms simultaneously (e.g., PIRCHE-II and Snow) improves the prediction of graft survival in kidney transplants. This means better risk classification and more informed decision-making for improved patient outcomes. These findings further pave the way for more personalized transplant strategies, optimized donor selection and longer-lasting graft function, ultimately transforming patient care in kidney transplantation. Congratulations to Matthias and everyone invloved in the paper's publication! Read the full article here: https://lnkd.in/ewijP38W #HLAmatching #kidneytransplant #immunology

Exciting news today! We're thrilled to announce our new innovation partnership with Devyser! With this ongoing collaboration, we aim to leverage PIRCHE's TxPredictor platform alongside Devyser's portfolio of novel biomarkers to deliver better and more personalised solutions for transplant recipient monitoring. The full press release is available for download below.

We were deeply saddened to learn of the passing of Frans Claas. A brilliant scientist, invaluable collaborator, and dedicated teacher, he will be greatly missed. Our sincere condolences go out to his family and loved ones. Thomas, Matthias, Ben, and the entire PIRCHE Team.