Allergy EAACI

#Asthma is a complex chronic disease marked by persistent airway inflammation and remains a significant global health concern, affecting over 350 million people worldwide. In this issue, Domingo et al., discuss the indirect and direct roles of IgE on airway epithelial cells, with a focus on allergic asthma. Abdu and Xia et al. study the IL-25/IL-17RB pathway as a potential therapeutic target for type 2 inflammatory disorders. Soendergaard et al. categorise patients based on their fractional exhaled nitric oxide response to anti-IL-5 biologics and evaluate the association of these categories with clinical outcomes. Pacheco Da Silva et al. identify exposure profiles for the long-term weekly use of  disinfectants and cleaning products by latent class analysis and assess their associations with asthma. Slob et al. investigate whether genotype-guided treatment improves asthma-related outcomes. Doyen and Migueres et al. compare the accuracies of the changes in fractional exhaled nitric oxide concentrations and sputum eosinophil counts in identifying asthmatic reactions induced by occupational agents during specific inhalation challenges. Daud et al. evaluate the role of WNT5a and TGF-β1 in asthmatic airway biopsies and in sputum and bronchial brushings assessed their role in remodelling. Hillson et al. assess the feasibility of point-of-care eosinophil measurements in preschool wheezers and related blood eosinophil counts to symptoms, lung function, and utility in predicting attacks. Hsin et al. assess the diagnostic performance and clinical utility of a single flow cytometry staining of basophils with major aeroallergen components. Martin-Gonzalez et al. identify whole blood DNA methylation markers associated with asthma exacerbations in Europeans. Bilò et al. identify real-world clusters of patients with severe asthma, based on baseline levels of biomarkers, and to understand their predictive role in response to biologics. Hsu et al. investigate the role of CD53 in mast cell responses and rype 2 inflammation. Michils et al. evaluate whether the improvement in FEV1 or the persistence of its deterioration in severe eosinophilic asthma patients on anti-IL-5 is related to a distinct evolution of the mucus score. Esnault et al. investigate whether human blood eosinophils are a source of oncostatin-M and analyze associations between oncostatin-M and airway eosinophilia, lung function, and other mediators in asthma. Hsu et al. conduct a case-control study to evaluate the effect of the exposure to acrylamide on asthma and its phenotypes. Chen et al. evaluate the changes in the features of allergic airway inflammation upon exposure to particulate matter 2.5. Sanchez-Torralvo and Testera-Montes et al. present an algorithm for organ-specific allergen challenges for the phenotyping of chronic respiratory diseases. journallergy.com

Cytokine Variations After Positive Oral Food Challenges in Adult-Onset Food Protein-Induced Enterocolitis. Corresponding author: Purificacion Gonzalez-Delgado Read the article here: doi.org/10.1111/all.16539 Gonzalez-Delgado et al. identified potential biomarkers for monitoring adult-onset food protein-induced enterocolitis syndrome (#FPIES) by measuring serum cytokines and chemokines levels in patients undergoing a supervised oral food challenge. Their findings support a similar mechanism between adult-onset and pediatric FPIES characterized by an IL-17 inflammatory response during an acute episode. Read more articles published in #Allergy on gastrointestinal diseases here: https://lnkd.in/gb89TBc #Allergy_journal

Jessy Elst, University Antwerp, Belgium, presents their research findings published in Allergy: Elst, J., Mertens, C., Van Houdt, et al. (2025), Flow Cytometry-Assisted Analyses of Individual Human Basophils, Mast Cells and T Cells in the Diagnosis of Immediate #DrugHypersensitivity: A Review. Allergy. Read the aricle here: doi.org/10.1111/all.16548 #Allergy_journal Watch videos of recent discoveries: journalallergy.com and youtube.com/@Allergy-TV https://lnkd.in/dj6ZGXz3 https://lnkd.in/dj6ZGXz3

Open Access: The Omics Landscape of Long COVID—A Comprehensive Systematic Review to Advance Biomarker, Target and Drug Discovery. Corresponding authors: Nadia Baalbaki, Anke H. Maitland-van der Zee Read the article here: doi.org/10.1111/all.16526 There has been significant progress in understanding the molecular mechanisms underlying long COVID. This is a systematic review of studies focusing on omics analyses of data from long COVID patients to identify biomarkers and develop targeted treatments. Read more articles published in #Allergy on #COVID-19 here:https://lnkd.in/dYczuku #Allergy_journal

Lawrence DuBuske, MD from the George Washington University Hospital, Washington, DC, USA, presents their research findings published in Allergy: Zielen, S., Bernstein, J.A., Pfaar, O., et al. (2025), Meta-Analysis of PQ Grass 27600 SU Efficacy and Quality of Life From Phase III Trials. Allergy. Read the article here: doi.org/10.1111/all.16535 #Allergy_journal Watch videos of recent discoveries: journalallergy.com and youtube.com/@Allergy-TV https://lnkd.in/gQxvw2eg

Take our #AllergyQuiz   Multi-oral allergen #immunotherapy (mOIT) combined with anti-IgE (omalizumab) could represent a rapid, safe and effective treatment combination that allows patients with multi-food allergy to achieve desensitisation. In a recent study, the relationship between regulatory T cells and Th2 cytokines has been studied in the context of desensitisation outcomes in omalizumab-assisted mOIT. In this regard, which of the following cytokines is related to the success or failure of desensitization outcomes in #omalizumab assisted-mOIT? Check the correct answer by reading the original article by Xiaoying Zhou and colleagues https://lnkd.in/gzhe9dTM Options:  A) IL-4 B) IL-10 C) IL-5 D) IL-9 #Allergy_journal Share your answer in the comment section below. We will post the answer tomorrow.

Open Access: Atopic Status Is Associated With Kidney Transplanted Recipients' Outcomes. Corresponding author: Luc Colas Read the article here: doi.org/10.1111/all.16529 In a prospective cohort of 516 kidney transplant recipients (KTR), Colas et al. performed time-dependent survival models to explore the role of atopic status. A stable atopic phenotype in KTR patients was found to increase the risk of biopsy-proven rejection and transplant loss. Read more articles published in #Allergy on clinical #immunology here: https://lnkd.in/ex3Y69tY #Allergy_journal

Jaeyu Park from the Kyung Hee University College of Medicine, South Korea, presents their research findings published in Allergy: Cho, J., Jo, H., Park, J., et al. (2025), TOP10-SCAR: A Global Pharmacovigilance Study on Medications Most Frequently Related to Severe Cutaneous Adverse Reactions. Allergy. Read the article here: doi.org/10.1111/all.16544 #Allergy_journal Watch videos of recent discoveries: journalallergy.com and youtube.com/@Allergy-TV https://lnkd.in/dKucvjk7

Open Access: Allergic Signature in Delayed Cross-Hypersensitivity to all Iodinated Contrast Media. First author: D. Do; corresponding author: M. Tauber Read the article here: doi.org/10.1111/all.16533 Do et al. present a case of a 77-year-old male patient with delayed cross-hypersensitivity reaction to all seven available iodinated contrast media, manifested as maculopapular exanthema affecting 70% of his body. The allergic signature was evaluated using skin tests, transcriptomic analysis of positive skin biopsies, and in vitro tests. Watch the video abstract here: https://lnkd.in/dEQtYHWD Read more articles published in #Allergy on drug hypersensitivity here: https://lnkd.in/gfs_z4g6 #Allergy_journal

Take our #AllergyQuiz The study by Benamar et al. investigates the role of Notch4+ regulatory T (Treg) cells and plasma viremia in shaping COVID-19 survival outcomes. The authors found that these two factors independently and in combination influence disease severity and 90-day mortality. They further explored the underlying immune mechanisms and potential therapeutic strategies, including Notch4 and pyroptosis inhibition in a mouse model of lethal influenza. Which of the following statements is correct regarding the study’s findings? Check the correct answer by reading the study by Benamar et al. doi.org/10.1111/all.16333 Options: A) Increased Notch4 expression on Treg cells was primarily associated with increased plasma viral load in COVID-19 patients. B) Plasma viremia was associated with increased monocyte pyroptosis, whereas Notch4+ Treg cells were linked to impaired suppressive function and reduced amphiregulin production. C) Patients with low Notch4+ Treg cells and viremia had the highest 90-day mortality. D) The combination of Notch4+ Treg cell inhibition and corticosteroid treatment provided the greatest protection against mortality in a mouse model of influenza. #Allergy_journal Share your answer in the comment section below. We will post the answer tomorrow.