NVIDIA's CUDA programming guide introduces CUDA, a parallel computing architecture that allows developers to use NVIDIA GPUs for general purpose computations. The guide discusses how GPUs are optimized for highly parallel workloads like graphics rendering, with more transistors devoted to data processing compared to CPUs. It presents CUDA as an extension of C that allows programmers to harness the parallel capabilities of NVIDIA GPUs for non-graphics applications. The document outlines CUDA's programming model, hardware implementation, application programming interface, and provides examples to illustrate GPU programming.