The JQuery POST method allows sending data from one file to another via AJAX calls in an asynchronous manner without page reloads. It works similarly to an HTML form POST but does not require page navigation. There are two ways to call the POST method - via $.ajax() or $.post(). It is commonly used for tasks like validating user input against existing data in real-time or retrieving dynamic data from a database to display on the page. Developers must ensure variable names match between the JavaScript and PHP code handling the request and response.