Annals of Internal Medicine

A study of emergency department (ED) visits from a nationally representative network of hospitals found that semaglutide adverse events can be very serious but are uncommon. Researchers estimate that less than 4 ED visits occur for every 1,000 patients prescribed semaglutide, most often for gastrointestinal symptoms. https://bit.ly/3XRLQVy

ICYMI: During #IM2025 Annals of Internal Medicine Friday Breaking News Plenary, the authors shared their research, findings, and engaged in a conversation with Annals Editor-in-Chief Christine Laine. Read the full articles on Annals.org.

At this morning’s #IM2025 plenary session, the authors of three breaking scientific articles on switching from dulaglutide to tirzepatide, AI-driven clinical recommendations, and cannabis for chronic pain management presented the findings of their research to a packed house. During the session, Christine Laine, M.D., MPH, FACP, Annals of Internal Medicine Editor-in-Chief and ACP Senior Vice President, sat down with the authors to discuss their research in depth and learn important insights beyond what was published: 🔹The difference in effectiveness of switching to tirzepatide based on the severity of obesity in a patient 🔹Patient satisfaction with AI-driven clinical recommendations during virtual care visits 🔹The importance of issuing best practice advice on cannabis or cannabinoids to clinicians Click the links below to read the full text of each breaking scientific article now: 🔹Comparison of Initial Artificial Intelligence (AI) and Final Physician Recommendations in AI-Assisted Virtual Urgent Care Visits https://bit.ly/43zEoSB 🔹Comparison of Dose Escalation Versus Switching to Tirzepatide Among People With Type 2 Diabetes Inadequately Controlled on Lower Doses of Dulaglutide: A Randomized Clinical Trial https://bit.ly/3Y9rirR 🔹Cannabis or Cannabinoids for the Management of Chronic Noncancer Pain: Best Practice Advice From the American College of Physicians https://bit.ly/3YgxvSC

Annals editors Christina Wee, MD, MPH, FACP, Stephanie Chang, MD, and Eliseo Guallar, MD, MPH, DrPH presented several important Annals Articles That You Should Know About at #IM2025 today. Look for full text at Annals.org. 🔹Effects of Noise and Public Setting on Blood Pressure Readings: A Randomized Crossover Trial 🔹Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes: A Systematic Review of Randomized Controlled Trials 🔹Potential Clinical and Economic Impacts of Cutbacks in the President’s Emergency Plan for AIDS Relief Program in South Africa: A Modeling Analysis: 🔹Effectiveness of Integrating Suicide Care in Primary Care: Secondary Analysis of a Stepped-Wedge, Cluster Randomized Implementation Trial: Annals of 🔹Cardiovascular Safety and Fracture Prevention Effectiveness of Denosumab Versus Oral Bisphosphonates in Patients Receiving Dialysis: A Target Trial Emulation 🔹Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers for Advanced Chronic Kidney Disease A Systematic Review and Retrospective Individual Participant–Level Meta-analysis of Clinical Trials 🔹Benefits and Risks Associated With Statin Therapy for Primary Prevention in Old and Very Old Adults Real-World Evidence From a Target Trial Emulation Study 🔹Long-Term Effect of Salt Substitution for Cardiovascular Outcomes A Systematic Review and Meta-analysis and

We are thrilled to be in #NOLA this week for ACP’s annual meeting, Internal Medicine 2025! We will be posting from #IM2025 all week to keep attendees and readers informed about important sessions and events and to share fun photos and updates from the meeting.

Patient navigation programs improved follow-up colonoscopy completion rates after an abnormal stool test, suggesting this is a highly effective intervention for patients eligible for a colonoscopy. Overall, the patient navigation intervention significantly increased one year follow up colonoscopy completion in those who received an abnormal stool test, resulting in a 13-percentage point increase. https://bit.ly/41TJHv0 University of Arizona Cancer Center University of Arizona Health Sciences

Submit your manuscript to Annals of Internal Medicine for an exceptional, unique publishing experience. Annals is the most-cited general internal medicine journal, is widely read with over a million page views each month, and receives significant coverage in the general media. Visit our Information for Authors page and watch the video to find out why our authors prefer to submit and publish in Annals: https://bit.ly/42c7BjZ

Study highlights persistent health disparities for Black children. Since 1950, Black infants and children in the US have consistently died at twice the rate of their White peers. The findings suggest the need for innovative social, economic and health care policies to address the structural causes of inequity affecting mortality in Black Americans. Read more: https://bit.ly/4iIxnUk

New: Available evidence supports continuing #buprenorphine during episodes of acute #pain for people with opioid use disorder. https://bit.ly/4iDhy0I

A new Annals #GraphicMedicine from Thomas Jefferson University medical student Andrew Engel thoughtfully details the brief history of physician-assisted #suicide. https://bit.ly/3XJdq76