Simple blood test for early detection of Alzheimer's disease
Alzheimer’s disease (AD), which impacts more than 50 million people globally, is characterized by brain cell malfunction and loss. Progressive memory loss, as well as reduced movement, cognition, and judgment, are all indications.
While most patients seek medical help and are diagnosed when they have memory problems, Alzheimer’s disease damages the brain for at least 10-20 years before symptoms occur.
For the first time, HKUST has designed a simplified and reliable blood test based on Chinese patient data for early identification and screening of Alzheimer’s disease (AD), with a 96 percent accuracy rate.
Now, a team led by Prof. Nancy IP, Vice-President for Research and Development at HKUST, has identified 19 out of the 429 plasma proteins associated with AD to form a biomarker panel representative of an “AD signature” in the blood. Based on this panel, the team has developed a scoring system that distinguishes AD patients from healthy people with more than 96% accuracy.
With the advancement of ultrasensitive blood-based protein detection technology, we have developed a simple, non-invasive, and accurate diagnostic solution for AD, which will greatly facilitate population-scale screening and staging of the disease.
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