New research from the University of Pittsburgh Swanson School of Engineering is shedding light on why some individuals with Down syndrome develop Alzheimer’s disease while others don’t. A study of a cognitively stable woman with Down syndrome revealed hidden Alzheimer’s pathology in the brain, offering insight into potential genetic and lifestyle factors that preserve cognitive function. These findings could influence future diagnostic tools and therapeutic drug trials, benefiting both the Down syndrome community and broader Alzheimer's research. “We are interested in trying to link neuroimaging with neuropathology, because we want to use information from neuropathology datasets to inform diagnostic and therapeutic criteria for individuals with Down syndrome before they pass away,” says Jr-Jiun Jean Liou, a postdoctoral scholar in the Department of Bioengineering. https://lnkd.in/gB4MJbGA
