MESO SCALE DIAGNOSTICS, LLC.’s Post

Oncology, immunology, neurobiology, cardiovascular, metabolic, & rare diseases, Ingenious’s catalog offers solutions your research focus. Ready to explore? #TP53Breakthroughs #BRCA1Research #EGFRInnovations #APOEInsights #KRASGenomics #IL6Pathways #CFTRDiscovery #VEGFAdvances

We are excited to launch a new subcategory for abstract submissions across several research areas: Neuroscience, Oncology, Cardiovascular & Systemic Diseases, Immunology/Inflammation, and Infection. This category covers the theranostic repurposing of molecular imaging probes and their integration with conventional therapies for treatment planning, monitoring, and response evaluation. Get more details and submit your abstract today! https://lnkd.in/evtwgYKa #Imageguided #Therapy #Theranostics #MolecularImaging #Neuroscience #Oncology #Immunology #Cardiovascular #Infection #Immunology

𝐀𝐫𝐞𝐚 𝐨𝐟 𝐅𝐨𝐜𝐮𝐬 𝐟𝐨𝐫 𝐌𝐚𝐣𝐨𝐫 𝐏𝐡𝐚𝐫𝐦𝐚𝐜𝐞𝐮𝐭𝐢𝐜𝐚𝐥 𝐂𝐨𝐦𝐩𝐚𝐧𝐢𝐞𝐬 (Part 3/5) Roche ✨ Tagline: Doing now what patients need next. Areas of focus: 1. Oncology: leading in cancer treatment and diagnostics. Example: Herceptin (trastuzumab) for breast cancer. 2. Immunology: advanced therapies for autoimmune diseases. Example: Actemra (tocilizumab) for rheumatoid arthritis. 3. Infectious Diseases: Tackling viral and bacterial infections. Example: Tamiflu (oseltamivir) for influenza. 4. Ophthalmology: Solutions for eye diseases. Example: Lucentis (ranibizumab) for age-related macular degeneration. 5. Neuroscience: Addressing neurological and psychiatric conditions. Example: Ocrevus (ocrelizumab) for multiple sclerosis. Reference: https://lnkd.in/gd_rTpQ4 #PatientFirst #Oncology #Immunology #InfectiousDiseases #Ophthalmology #Neuroscience #Roche 🔬👁️🌍

☑️ *READ ASTRACT BELOW:* Breast cancer leptomeningeal metastasis (BCLM), where tumour cells grow along the lining of the brain and spinal cord, is a devastating development for patients. Investigating this metastatic site is hampered by difficulty in accessing tumour material. Here, we utilise cerebrospinal fluid (CSF) cell-free DNA (cfDNA) and CSF disseminated tumour cells (DTCs) to explore the clonal evolution of BCLM and heterogeneity between leptomeningeal and extracranial metastatic sites. Somatic alterations with potential therapeutic actionability were detected in 81% (17/21) of BCLM cases, with 19% detectable in CSF cfDNA only. BCLM was enriched in genomic aberrations in adherens junction and cytoskeletal genes, revealing a lobular-like breast cancer phenotype. CSF DTCs were cultured in 3D to establish BCLM patient-derived organoids, and used for the successful generation of BCLM in vivo models. These data reveal that BCLM possess a unique genomic aberration profile and highlight potential cellular dependencies in this hard-to-treat form of metastatic disease. Fitzpatrick A, Nat Commun. 2023 Nov 16;14(1):7408. doi: 10.1038/s41467-023-43242-x. PMID: 37973922; PMCID: PMC10654396. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

📣 𝐓𝐡𝐞 𝐥𝐚𝐫𝐠𝐞𝐬𝐭 𝐜𝐨𝐥𝐥𝐞𝐜𝐭𝐢𝐨𝐧 𝐨𝐟 𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐚𝐥𝐥𝐲 𝐞𝐧𝐠𝐢𝐧𝐞𝐞𝐫𝐞𝐝 𝐦𝐨𝐮𝐬𝐞 𝐦𝐨𝐝𝐞𝐥𝐬 𝐣𝐮𝐬𝐭 𝐠𝐨𝐭 𝐛𝐢𝐠𝐠𝐞𝐫. Swipe through to see the newest strains now available for a variety of disease indications. Feel free to reach out if you have questions about a model you see! #PreclinicalResearch #Immunology #Oncology #Neurology

☑️ *READ DESCRIPTION BELOW:* The main models to mantain the interaction between gastrointestinal cancers patient-derived organoid (PDOs) and immune cells. A Model based in the use of ALI-PDOs that preserve the immune cells for almost 60 days. B Co-culture interaction between PDOs and T-cells derived form same patient (autologous) with the aim to generate tumor-responsive as a cancer treatment. C Co-culture interaction based on PDOs and PBMC derived from healthy controls (allogenic) with the aim to generate cytotoxicity activity against to the tumor cells from CD8 T-cells Obreque J, Biol Res. 2023 Dec 2;56(1):63. doi: 10.1186/s40659-023-00476-9. PMID: 38041132; PMCID: PMC10693174. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

in case you missed it, here is the replay of our webinar dedicated to the most promising clinical trials based on our #SIMOA technology Milena Dumont Milutinovic and dr Nicholas Ashton will drive you into a deep overview of our main project in collaboration with the most important Pharma company all over the world. We are waiting for you… #Quanterix #SIMOA #neurology #oncology #neurodisease #alzheimer #parkinson #biomarker #proteomics #pharma #clinicaltrial #drug #research

Why is it so hard to keep weight off, and why does weight regain, or "rebounding," happen so often after a period of weight loss? This intriguing article suggests a possible explanation: an #epigenetic mechanism in fat cells. This also reminds my postdoc work demonstrating the critical epigenetic regulation in embryonic stem cells (#ESC) by TET1 (Mol Cell 2011), human #cancer by TET2 (Cell 2012), and eye and #neural development by TET3 (Cell 2012).

🌌 𝐔𝐧𝐥𝐨𝐜𝐤𝐢𝐧𝐠 𝐭𝐡𝐞 𝐔𝐧𝐢𝐯𝐞𝐫𝐬𝐞 𝐨𝐟 𝐊𝐢𝐧𝐚𝐬𝐞 𝐀𝐜𝐭𝐢𝐯𝐢𝐭𝐲 🌌 Much like the stunning interstellar networks in this image, #kinases form intricate #signaling pathways that regulate essential biological processes across #cancer, #immunology, and #neurology. At PamGene, we harness the power of 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧𝐚𝐥 𝐤𝐢𝐧𝐨𝐦𝐢𝐜𝐬 to map these "celestial pathways" and uncover insights that drive breakthroughs in precision medicine. ✨ 2024 𝐇𝐢𝐠𝐡𝐥𝐢𝐠𝐡𝐭𝐬 This year, through meaningful collaborations, we: ✅ Decoded critical kinase activity patterns in complex diseases. ✅ Explored biomarkers to guide therapeutic innovation. ✅ Paved the way for targeted solutions in oncology, immunology, and neurology. 🔭 𝐋𝐨𝐨𝐤𝐢𝐧𝐠 𝐀𝐡𝐞𝐚𝐝 𝐭𝐨 2025 As we stand at the threshold of a new year, we look forward to continuing our journey to unravel the “galaxies” of cellular signaling, transforming kinase insights into impactful clinical outcomes. 🎉 𝓦𝓲𝓼𝓱𝓲𝓷𝓰 𝔂𝓸𝓾 𝓪𝓵𝓵 𝓪 𝓱𝓪𝓹𝓹𝔂, 𝓱𝓮𝓪𝓵𝓽𝓱𝔂, 𝓪𝓷𝓭 𝓲𝓷𝓷𝓸𝓿𝓪𝓽𝓲𝓿𝓮 2025! With gratitude and excitement for the year ahead, The PamGene Team #PamGene #Kinomics #KinaseResearch #PrecisionMedicine #Cancer #Immunology #Neurology #HappyNewYear2025

EORTC - European Organisation for Research and Treatment of Cancer Brain Tumor Group Strategy Meeting 2024-2027 led by Prof. Dr. Julia Furtner-Srajer, Danube Private University Austria (DPU). Prof. Dr. Julia Furtner-Srajer took over the leadership of the Imaging Committee of the European Organization of Research and Treatment of Cancer (EORTC) Brain Tumor Group in Brussels. EORTC is an independent oncology research organization which coordinates and conducts international translational and clinical research to improve the standard of oncology therapies for patients. The EORTC Brain Tumor Group Strategy Meeting takes place every year and coordinates the planning and implementation of various international neuro-oncological studies where the Danube Private University is proud to play an instrumental role as cooperation partner. #research #neurology #neuroscience #braintumour #braincancer #medicalimaging #oncology #therapies #healthcare #improvedhealthcare #cooperationpartners #medicine #medizinstudium #medizinstudiumösterreich #studyinaustria #studymedicine #eortc #danubeprivateuniversity