GAOYUAN BIOCHEM’s Post

JIM│ How much tidal volume is sufficiently low to be called “protective lung ventilation” Link: https://buff.ly/3R0IITV Ultra-low tidal volume (ULT) is an appealing alternative for severe acute respiratory distress syndrome (ARDS) patients with the aim to alleviate excess lung stress and strain. In a recent article, Richard and colleagues showed that ULT without extracorporeal carbon dioxide removal did not improve prognosis in moderate-to-severe COVID-19-related ARDS patients (VT4COVID study). However, several reasons should be considered before drawing the definite conclusion about the ULT strategy in severe ARDS. First, the severity of included patients may be not as high as the significantly low PaO2/FiO2 ratio shown at baseline in VT4COVID study due to the dissociation between relatively preserved lung mechanics and the severity of hypoxemia. Second, the benefit effects of ULT on plateau pressure and driving pressure were marginal in VT4COVID study. Third, although mechanical power was significantly reduced after implementing ULT strategy in VT4COVID study, the magnitude was not large enough to translate into mortality benefit possibly due to obvious respiratory rate increase aiming to keep partial pressure of arterial carbon dioxide and acid-base state at acceptable level. In conclusion, the results of VT4COVID study provided the important insights of ULT strategy without ECCOR2 in moderate-to-severe COVID-19-related ARDS patients. In ARDS patients with preserved lung mechanics demonstrating low plateau pressure and driving pressure, ULT strategy without ECCOR2 may not be a “Less is More” method in mechanical ventilation.

Perhaps some form of #griselssyndrome is much more common in adults than previously thought? It is thought to be caused by upper respiratory tract infections and the pathophysiology consists of relaxation of the transverse ligament of the atlanto-axial joint. #CCI #neckinstability #MESpine #LongCovid #postcovid #hypermobility #MECFS #covidsequelae #LookAtTheSpineSeeWhatYouFind

Treating gum disease is important to keep your teeth and protect your heart: "Whilst there is no direct evidence for the benefits of periodontal treatment on complex cardiovascular outcomes, there is clear evidence for the effect of periodontal therapy on surrogate measures of cardiovascular diseases, arterial blood pressure and stiffness, and sub-clinical cardiovascular disease markers." See more here: https://lnkd.in/gTTWz_k9. And start prescribing Perio Protect. Scaling is good acute care. Perio Protect addresses the root causes of chronic infection and inflammation. See the research at https://lnkd.in/g4VrxMtT and start prescribing today. #PerioProtect #PerioTrayTherapy #antibioticstewardship

Maintaining gum health is crucial for the overall well-being of your teeth and cardiovascular system. You'll find valuable insights in this post by Tanya Dunlap, Vice President of Perio Protect. Take a look!

Pulmonary edema is a condition characterized by the accumulation of fluid in the alveoli and interstitial spaces of the lungs. This fluid accumulation impairs gas exchange and can lead to significant respiratory distress. Pulmonary edema can be classified into cardiogenic and non-cardiogenic types, each with distinct underlying mechanisms and treatment approaches Cardiogenic Pulmonary Edema: This type is often associated with heart failure, myocardial infarction, and valvular heart disease. It results from increased pressure in the pulmonary circulation due to inadequate cardiac output. Non-Cardiogenic Pulmonary Edema: Includes conditions such as ARDS, pneumonia, sepsis, and exposure to toxins. It is characterized by increased capillary permeability and inflammatory responses. Other Causes: Includes high-altitude pulmonary edema, neurogenic pulmonary edema, and renal failure-related pulmonary edema.

Acute hyperoxia (breathing in 100% oxygen) causes coronary blood vessel narrowing (i.e., vasoconstriction) and raises blood pressure in adults with peripheral artery disease. https://lnkd.in/eq-33QcH

High and low levels of eosinophils have been found to be associated with increased severity of bronchiectasis and exacerbations. Check out the link for more information: https://buff.ly/3W03KFx #RespiratoryHealth #Bronchiectasis https://buff.ly/3W03KFx

New CJCOpublication. Prevention and management of cardiovascular disease in primary care: A comment on the PEER simplified lipid guideline https://lnkd.in/gQ8-fJVs

If an elevated Lp(a) level is found in a patient for primary prevention, a CT scan of the coronary arteries with assessment of the coronary artery calcification (CAC) score should be considered for more appropriate risk stratification

In #COPD, higher frequency and severity of #AECOPD increases the risk for myocardial infarction and pulmonary embolism. Read More: https://lnkd.in/eWzC-Xh7