Glint Lab

A great video by Visiopharm showcasing their membrane-aware cell segmentation model for RNA ISH analysis: an impressive step forward from nucleus expansion models, especially for increasing accuracy in ISH studies. If you’re exploring RNA ISH analysis, we highly recommend checking out the full video for a helpful walkthrough of the techniques: https://lnkd.in/gp4uG_3e Thanks to the Visiopharm team: Daniel Winkowski Regan Baird Leticia Manosso and Randy Chen from Molecular Instruments! At Glint Lab, we’ve been excited to offer both nucleus expansion and membrane-aware segmentation approaches for RNA ISH image analysis. These tools help us deliver precise, high-quality results for our clients working on complex gene expression studies. #RNA #ISH #Histopathology

Choosing Between #Multiplex #IHC (#mIHC) and #Multiplex #Immunofluorescence (#mIF): Each method has unique strengths and limitations that make them suited for different research goals. Let’s dive into the pros and cons of both approaches to help guide your decision. Why Choose #mIHC? ➡️ Preserves Morphology: With chromogenic dyes, mIHC offers unmatched clarity for evaluating tissue structures like epithelial architecture and stroma. ➡️ Visual Co-Localization: Chromogenic dyes, particularly Roche’s translucent purple, yellow, and teal, enable the visualization of multiple markers while preserving tissue morphology. These dyes blend to reveal co-localization through distinct new colors: 🎨 Purple + Yellow: Fiery red 🎨 Yellow + Teal: Mild green 🎨 Purple + Teal: Dark indigo blue This approach provides clear insights into spatial relationships between markers, enhancing co-expression analysis. ➡️ Compatibility with Pathology Review: Chromogenic stains align well with traditional H&E evaluation, making them easier for pathologists to interpret. However, mIHC has its limitations: ⚠️ Challenge with multiple markers: Visualizing more than two co-localized markers becomes increasingly complex, as overlapping dyes can obscure clear interpretation. Color deconvolution requirements: If the tissue has high endogenous pigment or uneven staining, distinguishing true signals can be difficult. When to Go with #mIF? mIF utilizes fluorophores for marker detection, providing flexibility and clarity in studying complex tissue environments. Here’s why it might be a better fit: ➡️ Individual channel analysis: Each marker is visualized in its unique channel, eliminating the need for color deconvolution. ➡️ Co-localization of multiple markers: mIF allows easy detection and analysis of interactions among three or more markers in the same tissue region through composite views. ➡️ Digital analysis readiness: mIF pairs seamlessly with quantitative image analysis platforms, enabling precise, automated data extraction. Still, mIF has its own challenges: ⚠️ Autofluorescence: Some tissues, such as skin or liver, may produce background fluorescence, complicating signal interpretation. ⚠️ Fading signals: Fluorophores can photobleach, requiring careful imaging and handling protocols. ⚠️ Morphology visibility: While mIF offers detailed molecular insights, it may not always capture tissue morphology as clearly as chromogenic stains. Finding the Best Fit for Your Study The choice between #mIHC and #mIF ultimately depends on your research needs, the marker combination, the complexity of the tissue being studied, and the analysis goals. At Glint Lab, we specialize in designing custom #multiplexassays tailored to your study goals. Whether your focus is on the spatial interplay of just a few markers or the comprehensive profiling of highly multiplexed panels, we’ll help you select the optimal detection strategy. #MultiplexImmunofluorescence #MultiplexIHC

🔬 #Specialstains are essential tools in histopathology, helping us uncover critical insights from key cellular and tissue structures. The key is that reliable scientific insights and accurate image analysis really depends on high-quality stained slides. Which is why, at Glint Lab, we spend much effort on perfecting our protocols and sourcing top-tier reagents, slides and control tissues. With trusted partners like StatLab , we’re confident in the #consistency of the reagents and the #reproducibility of our protocols. StatLab also provides high-quality control tissues that allow us to double and triple-check the #precision of our protocols before applying them to your precious samples. Quality reagents, optimized protocols, and our lab team’s expertise all come together to create high-quality slides that our clients can count on. Glint Lab also offers #IHC, #IF, #multiplexpanels, #RNAScope, and much more, always focused on delivering the highest quality #histopathology services to our clients.  #SpecialStains #HistopathologyReagents #DigitalPathology #StatLab

Our image analysis team director Jason Roberts is a wizard when it comes to generating actionable insights from digital images of pathology slides! If you need help with your digital pathology #imageanalysis, make sure you reach out to Jason. And, if you need help with a histopathology project message Glint Lab on LinkedIn or contact our science team at scientist@glintlab.com 🔬 Don't forget to follow our page Glint Lab for more content like this! Thanks, Visiopharm for this nice post and for the software solutions that help us help our clients! #histopathogy #digitalpathology #pathology

It was great to bump into our very own Resolute Science team at #JPM2025! It’s always inspiring to see the incredible companies that we serve pushing boundaries and growing. Wishing them the best of luck in finding the right investors who share their passion for human health and great science! Rick Crum | Faith Barnett MD, PhD, FAANS | ANDRE BASBAUM | Sean Premeau, RAC, PMP

✨ Glint Lab will be in San Francisco for the JPM Healthcare Conference! ✨ Let’s make the most of this incredible week together! If you’re in San Francisco during the conference, we’d love to meet in person! Whether it’s a quick coffee chat, a brainstorming session, or simply exchanging ideas, we’re looking forward to engaging with like-minded professionals. Feel free to comment below, send Misagh Naderi, PhD a direct message, or go to our calendar👇to coordinate a time to meet. 🗓️ https://lnkd.in/gXvKYPky

Supporting innovators like Glint Lab is what drives us forward. Glint Lab is a full stack precision pathology laboratory dedicated to preclinical and early-stage discovery. Ami Lau, COO of Glint Lab, shares how PathcoreFlow™ has helped their team overcome complex image analysis challenges, unlocking new possibilities in preclinical and drug discovery research. “We rely on PathcoreFlow to deliver images, annotations, and analysis results worldwide; its seamless integration with Visiopharm is key to our image analysis as a service offering.”  -Ami Lau, COO of Glint Lab We’re proud to support the groundbreaking work at Glint Lab and look forward to seeing how this collaboration continues to shape the future of image analysis. #Immunooncology #Multiplex #PrecisionMedicine #SpatialBiology #DigitalPathology #DrugDiscovery #DrugDevelopment #Biopharmaceuticals #CancerResearch #Biopharma #Biotechnology #Biotech #MedTech #Pathcore

The BIOSECURE Act is already impacting U.S. biotech amid other global shifts like the 16th BRICS Summit and the ongoing U.S.-China trade war. We explore the challenges and opportunities this legislation creates for innovation and partnerships. Interested to hear your thoughts! 👉 You can read the article here: https://lnkd.in/gwgQdX7A

The BIOSECURE Act is already impacting U.S. biotech amid other global shifts like the 16th BRICS Summit and the ongoing U.S.-China trade war. We explore the challenges and opportunities this legislation creates for innovation and partnerships. Interested to hear your thoughts! 👉 You can read the article here: https://lnkd.in/gwgQdX7A