Journal Clubs Summary Methodology Score: 3/5 Usefulness Score: 3.5/5
Rehrer MW, et al.
Ann Emerg Med. 2016 Nov;68(5):608-613.
Abstract Link
This single centre, randomized, triple-blinded, control trial did not demonstrate noninferiority of a single dose of dexamethasone compared to standard 5 day course of prednisone for adult asthma exacerbations. In most patients, prednisone for 5 days should still be used. A select group of patients with poor compliance may still benefit from a single dose of dexamethasone although further studies are needed. By: Dr. Simeon Mitchell
Epi lesson Equivalence or Non-Inferiority Trials
Most RCTs aim to determine whether one intervention is superior to another (superiority trials). Often a non-significant test of superiority is wrongly interpreted as proof of no difference between the two treatments. By contrast, equivalence trials aim to determine whether one (typically new) intervention is therapeutically similar to another (usually e…
Rehrer MW, et al.
Ann Emerg Med. 2016 Nov;68(5):608-613.
Abstract Link
This single centre, randomized, triple-blinded, control trial did not demonstrate noninferiority of a single dose of dexamethasone compared to standard 5 day course of prednisone for adult asthma exacerbations. In most patients, prednisone for 5 days should still be used. A select group of patients with poor compliance may still benefit from a single dose of dexamethasone although further studies are needed. By: Dr. Simeon Mitchell
Epi lesson Equivalence or Non-Inferiority Trials
Most RCTs aim to determine whether one intervention is superior to another (superiority trials). Often a non-significant test of superiority is wrongly interpreted as proof of no difference between the two treatments. By contrast, equivalence trials aim to determine whether one (typically new) intervention is therapeutically similar to another (usually e…