Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomized feasibility trial
Journal Club SummaryMethodology Score: 3/5 Usefulness Score: 2/5
Jairath V, et al. Lancet.2015 Jul 11;386(9989):137-44 Abstract Link
This open label, cluster randomized feasibility trial based in six university hospitals in the United Kingdom including 936 patients demonstrated no difference in measured clinical outcomes between the liberal and restrictive blood transfusion groups for acute upper gastrointestinal bleeds. Although this was a feasibility trial and many limitations of the study were identified (balance between clusters, adherence to protocol, contamination, loss to follow-up), it was felt even a large non-inferiority trial is unlikely to find a difference in patient outcomes with the two transfusion regimens. By: Dr. Shannon McCarter
Epi lessonCluster Randomized Controlled Trials
A cluster randomized trial is a trial in which individuals are randomized in groups (i.e. the group is randomized, not the individual); for example, all patients treated By: a part…
Jairath V, et al. Lancet.2015 Jul 11;386(9989):137-44 Abstract Link
This open label, cluster randomized feasibility trial based in six university hospitals in the United Kingdom including 936 patients demonstrated no difference in measured clinical outcomes between the liberal and restrictive blood transfusion groups for acute upper gastrointestinal bleeds. Although this was a feasibility trial and many limitations of the study were identified (balance between clusters, adherence to protocol, contamination, loss to follow-up), it was felt even a large non-inferiority trial is unlikely to find a difference in patient outcomes with the two transfusion regimens. By: Dr. Shannon McCarter
Epi lessonCluster Randomized Controlled Trials
A cluster randomized trial is a trial in which individuals are randomized in groups (i.e. the group is randomized, not the individual); for example, all patients treated By: a part…