Mirxes

April marks Esophageal Cancer Awareness Month, and we would like to share an excellent set of infographics created by Lianhe Zaobao 联合早报 a few months ago. According to World Cancer Research Fund, Esophageal cancer is the 11th most common cancer worldwide – 7th most common cancer in men and the 16th most common cancer in women. Studies also found that esophageal cancer is much more prevalent among Asians, who account for up to 80% of global cases and deaths. Driven by the need for early detection, Mirxes is actively involved in Project CADENCE. This ambitious 3-year study, a collaboration with leading Singaporean clinical experts and institutions, aims to develop a blood-based multi-cancer screening test (MCST). CADENCE (CAncer Detected Early caN be CurEd) will investigate microRNA expression and other biomarkers like DNA methylation patterns in a large multi-centre cohort of over 20,000 participants – the largest regional cancer detection study to date. This groundbreaking research targets the nine most prevalent cancers in Singapore, including esophageal cancer, with the goal of significantly improving early diagnosis and patient outcomes. Pls see Lianhe Zaobao's full FB post here: https://lnkd.in/gcZQeSbQ #miRNA #detectwithmirxes #research #preventivehealthcare #earlydetection #healthcare #cancer #healthscreening #precisionmedicine #RNA #miRNA #earlydetectionsaveslives

To all our Muslim colleagues, partners and stakeholders in Singapore and around the world, we extend our warmest wishes for a joyous and blessed Hari Raya Aidilfitri / Eid Mubarak. May this festive season bring you peace, happiness and prosperity!

At #Mirxes, we are driven by a mission to solve real-world healthcare challenges in the cancer care continuum, and are always on the lookout for talented individuals to join our dynamic team. If you are passionate about biotechnology and eager to make a tangible impact, explore our career page regularly for exciting opportunities to grow with us. https://lnkd.in/eiX6e8ZW #TeamMirxes #careers #hiring #precisionmedicine #detectwithmirxes #preventivehealthcare #earlydetection #healthcare #cancer #healthscreening #RNA #miRNA #earlydetectionsaveslives

Our COMPASS (Comprehensive Assay) webpage is now live! Discover how COMPASS Tissue, our advanced genomic profiling test, analyses 1,021 cancer-related genes using next-generation sequencing (NGS). Explore personalised treatment recommendations based on a wide range of biomarkers, covering 5 major classes of cancer drugs approved by the US FDA and EMA, recommended by the NCCN and ESMO Guidelines, or currently being used in clinical trials as investigational drugs. To find out more: https://lnkd.in/gxFVNn6C #preventivehealthcare #precisionmedicine #biotech #researchanddevelopment #earlydetection #earlydetectionsaveslives #healthcare #cancerearlydetection #DNA #RNA #clinical #genomics #ngs

Exciting news! The groundbreaking research identifying microRNA (miRNA) signatures for facilitating early detection and classifying pulmonary hypertension (PH), in which #Mirxes played a significant role, has been accepted for publication in Circulation: Genomic and Precision Medicine! (𝘊𝘪𝘳𝘤𝘶𝘭𝘢𝘵𝘪𝘰𝘯 𝘪𝘴 𝘵𝘩𝘦 𝘱𝘳𝘦𝘮𝘪𝘦𝘳 𝘴𝘤𝘪𝘦𝘯𝘵𝘪𝘧𝘪𝘤 𝘫𝘰𝘶𝘳𝘯𝘢𝘭 𝘰𝘧 𝘵𝘩𝘦 𝘈𝘮𝘦𝘳𝘪𝘤𝘢𝘯 𝘏𝘦𝘢𝘳𝘵 𝘈𝘴𝘴𝘰𝘤𝘪𝘢𝘵𝘪𝘰𝘯.)   This achievement would not have been possible without the dedication and collaborative spirit of every party involved. It is, in fact, the culmination of a global effort, integrating years of data from leading institutions like Imperial College London, the University of Sheffield, Royal Papworth Hospital NHS Foundation Trust, the University of Cambridge, and Brigham and Women’s Hospital. It also incorporates data from the CIPHER trial, a 44-site, 9-country prospective miRNA biomarker study led by Dr Yiu-Lian Fong, who was previously the programme leader at Janssen and currently serves Mirxes as the Scientific Advisor, and sponsored by #Janssen.   Building on the 2024 Nobel Prize-winning discovery of miRNAs, a type of small RNA molecules that play a pivotal role in gene regulation, and leveraging Mirxes’ proprietary miRNA detection technology, data science capabilities and extensive experience in developing liquid biopsy tests, our findings demonstrate that miRNAs can significantly enhance PH diagnosis and classification.   PH is a complex, heterogeneous disease comprising five major groups with numerous subgroups. Current diagnosis and classification, primarily reliant on hemodynamics which can only be measured by invasive right catheterisation, have yielded limited progress in developing effective treatments for each (sub)group. Our research demonstrates that miRNA biomarker signatures can elucidate the underlying molecular mechanisms of this heterogeneity, enabling refined patient classification based on fundamental molecular pathophysiology, and ultimately driving precision therapy. 𝐊𝐞𝐲 𝐈𝐧𝐬𝐢𝐠𝐡𝐭𝐬   𝐒𝐮𝐩𝐞𝐫𝐢𝐨𝐫 𝐂𝐥𝐚𝐬𝐬𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧: miRNA signatures outperform traditional biomarkers in distinguishing PH subgroups. 𝐑𝐞𝐟𝐢𝐧𝐞𝐝 𝐃𝐢𝐚𝐠𝐧𝐨𝐬𝐭𝐢𝐜 𝐀𝐜𝐜𝐮𝐫𝐚𝐜𝐲: Combining miRNA data with clinical parameters improves diagnostic precision, empowering personalised patient care. Interested in learning more about how miRNA biomarkers can advance PH care or exploring potential collaborations? Let's connect! Special thanks to our collaborators: The Janssen Pharmaceutical Companies of Johnson & Johnson, Allan Lawrie, Dennis Wang, Ioana Preston, Luke Howard, Mark Toshner, Bradley Maron, David Kiely, Kelly M Chin, Martin Wilkins and Stephan Rosenkranz #pulmonaryhypertension #miRNA #precisionmedicine #genomics #liquidbiopsy #teamwork #collaboration #researchinnovation #healthcare #RNA #earlydetection

We are glad to announce the launch of our newly upgraded webpage for Mirxes Genomics!   Our team is dedicated to enhancing your online experience, making it easier than ever for you to access our extensive range of research services and discover our unique strengths as a leading NGS service provider.   We invite you to visit our updated website and explore the new content and features. Thank you for your continued support, and we look forward to improving your service journey with our expanded online presence!   Visit our newly upgraded webpage now! https://lnkd.in/dhycscwH   #preventivehealthcare #precisionmedicine #biotech #researchanddevelopment #earlydetection #earlydetectionsaveslives #healthcare #cancerearlydetection #DNA #RNA #research #Genomics #ngs #sequencing #spatial #transcriptomics #singlecell #metagenomics #bioinformatics #multiomics

To foster collaboration and knowledge exchange, our Thailand Country Head, Gao Li, shared about #Mirxes and our pioneering miRNA technology to PhD fellows at Mahidol University last week. The presentation detailed Mirxes' journey from a research lab to a global leader in our field. Adding a personal touch, Dr Zou Ruiyang, our Co-Founder and Chief Technology Officer (CTO), provided a recorded message of encouragement, urging the aspiring researchers to embrace curiosity, determination, and a genuine interest in translating their innovations into real-world impact. He emphasised that aligning research goals with benefits for humanity, the nation, and the company is crucial for success in the biotech and scientific fields. The session also welcomed research fellows from Thailand's National Science and Technology Development Agency (NSTDA), creating a dynamic platform for exchange. This engagement session reflects Mirxes' dedication to building strong relationships with the research community in the markets we are in. We are always keen to share our latest technologies and R&D developments with like-minded local partners to foster a collaborative environment for mutual growth and breakthroughs. #precisionmedicine #detectwithmirxes #preventivehealthcare #earlydetection #healthcare #cancer #healthscreening #RNA #miRNA #earlydetectionsaveslives #Thailand #ASEAN #collaboration

At #Mirxes, women are driving our success. They hold pivotal leadership positions across critical departments, including Legal, Human Resources, Genomics, R&D, and Market Development (Japan). As we celebrate International Women's Day （IWD) 2025, we are reminded (again) of their invaluable contributions and look forward to their continued leadership in shaping Mirxes' future 💪 Zhao Pan Vivian Wang Vitoria Owyong Li-Foong Yoong Deepika Kanojia Jaiden Ho #precisionmedicine #detectwithmirxes #preventivehealthcare #earlydetection #healthcare #cancer #healthscreening #RNA #miRNA #earlydetectionsaveslives #women

Want to make a real impact on global healthcare? At #Mirxes, we are pioneering innovative diagnostic solutions that are advancing early disease detection and improving lives. We have some job openings now (see list below) and are seeking passionate individuals to join us in shaping the future of precision medicine. - Senior Medical Technologist/Medical Technologist I/II, Molecular & NGS - Sales Specialist, Discovery Genomics - Project Management Specialist, Discovery Genomics - Sales Account Manager, Clinical Genomics - Research Scientist, Genomics - QA and Operational Compliance Executive - QC Supervisor - Process Development Lead - Sales Specialist (Malaysia) - Technical and Sales Specialist/Manager, Life Sciences (Japan) If you are ready to embark on a meaningful career, check out our career page: https://lnkd.in/eiX6e8ZW #careers #hiring #precisionmedicine #detectwithmirxes #preventivehealthcare #earlydetection #healthcare #cancer #healthscreening #RNA #miRNA #earlydetectionsaveslives

The accelerating pace of biotechnology is driving significant advancements in precision medicine. We are now witnessing the power of cancer biomarkers in patient stratification, the potential of miRNA in early cancer detection, and the efficacy of biomarker-guided targeted therapies, all contributing to more personalised and effective cancer treatment. Recognising the importance of public understanding and knowledge sharing, #Mirxes engages with the community regularly. Last week, our VP of Genomics, Zhao Pan, had an engaging sharing session with Singapore Chinese Chamber of Commerce & Industry members from diverse backgrounds. The session was a testament to the community's keen interest on this topic, with participants posing thoughtful questions. Pan also found the session rewarding, appreciating the breadth of perspectives exchanged. Through our engagement efforts, we hope early detection and effective management, facilitated by technological advancements, can significantly reduce the fear associated with a cancer diagnosis in our community. #detectwithmirxes #preventivehealthcare #earlydetection #healthcare #cancer #healthscreening #precisionmedicine #RNA #miRNA #earlydetectionsaveslives