Enzymit

We're #hiring a new Junior Research Scientist! Join Israel’s leading synthetic biology company and be part of a cutting-edge, fast-growing team. Know someone who might be a great fit? Let them know!

Enzymit is pleased to announce the #promotion of Noga Alon, Olga Bluvshtein, and Nitzan Kutnowski to Team Leaders at Enzymit! Olga Bluvshtein has made significant contributions during her time at Enzymit, consistently demonstrating outstanding dedication and accountability. Most notably, she successfully led the scale-up of enzymes for the HA project. By developing fermentation processes, Olga and her team have ensured a consistent and sufficient enzyme supply—an achievement essential for HA and side reaction development, tech transfer for large-scale production, and the attainment of our major PoC milestone. Noga Alon has consistently shown exceptional involvement in nearly all aspects of Enzymit’s activities. Her notable achievements include developing the analytical infrastructure for the HA project, leading the development and scale-up of side reactions and downstream processing for HA production, and establishing the groundwork for the company’s documentation and database. Nitzan Kutnowski's dedication and hard work have been instrumental to our progress. His contributions to establishing the purification process for Enzymit’s enzymes and his leadership in developing and scaling up the HA one-pot reaction have been invaluable. For these achievements and many more, please join me in congratulating Noga, Olga, and Nitzan on this well-deserved promotion, and in wishing them continued success in their new roles.

The rise of DeepSeek is yet another sign that knowledge and expertise are becoming commodities. What does this mean for biotech? Check out our latest post to find out! 😃

🌟 We're Hiring! Join Enzymit's Fermentation Team 🌟 Calling all recent grads in Biology or Biotechnology! We’re looking for a Laboratory Technician to support our Fermentation Team in Rehovot, Park Hamada. Gain hands-on experience in a cutting-edge start-up focused on bioproduction, with opportunities for growth and learning. 💻 Apply now: https://lnkd.in/daYkvqvU #BiotechCareers #Hiring #Enzymit

🎉 Farewell 2024, Hello 2025! 🎉 As we step into a new year, we at Enzymit reflect on an incredible 2024 filled with growth, innovation, and meaningful milestones. ✅ Key highlights from 2024: 1. Achieved successful lab-scale production of #cellfree Human Milk Oligosaccharides (HMO’s) DSLNT, LNFP1 and non-dairy lactose. 2. Advanced pilot-scale production for cell-free Hyaluronic Acid (HA), a major step toward commercialization. 3. Secured a $10M Series A funding round led by Khosla Ventures and Grove Ventures, reinforcing our commitment to transforming bioproduction. Honored as a 2024 Technology Pioneer by the World Economic Forum and a winner of the Israel Innovation Authority רשות החדשנות Dream Team award. Published our computational protein design algorithm in #PNAS and partnered with global leaders to disrupt traditional manufacturing. 🌍 This year, we continued driving our vision: enabling sustainable, scalable production of specialty molecules through AI-driven enzyme design and cell-free manufacturing. As we look to 2025, our focus sharpens: 🔹 Expanding collaborations in HA production to meet pharmaceutical and cosmetic market needs. 🔹 Advancing our bioreactor technologies to bring new molecules to life, from carbohydrates to hydrocarbons to disrupt humanity’s dependence on non-renewable resource 🔹 Strengthening partnerships and exploring opportunities to deliver on the promise of cell-free manufacturing. Thank you to our incredible team, investors, partners, and supporters for being part of this journey. Here's to another year of breakthroughs and building a better, more sustainable future. 💡 What are you most excited to achieve in 2025? Let us know in the comments! Happy New Year! 🥂 The Enzymit Team

𝐖𝐡𝐲 𝐃𝐢𝐝 𝐖𝐞 𝐂𝐡𝐨𝐨𝐬𝐞 𝐂𝐨𝐬𝐦𝐞𝐭𝐢𝐜𝐬 𝐚𝐬 𝐭𝐡𝐞 𝐋𝐚𝐮𝐧𝐜𝐡𝐩𝐚𝐝 𝐟𝐨𝐫 𝐨𝐮𝐫 𝐂𝐞𝐥𝐥-𝐅𝐫𝐞𝐞 𝐏𝐥𝐚𝐭𝐟𝐨𝐫𝐦? Curious about the strategic thinking behind our approach? Discover the factors that make the cosmetics market the ideal starting point for cell-free innovation. 🔗 Learn more: https://lnkd.in/dDf3RkjW

🚀 Exciting Announcement: 𝗦𝗼𝗹𝘃𝗜𝗧 is Now Open Source on Github! 🎉 Published in PNAS (Proceedings of the National Academy of Sciences) earlier this year, this innovative pipeline is now available to the community! You can read the full paper here: PNAS: Context-dependent design of induced-fit enzymes using deep learning. 🔬 𝗪𝗵𝗮𝘁 𝗶𝘀 𝗦𝗼𝗹𝘃𝗜𝗧? SolvIT is a cutting-edge computational tool designed to streamline protein solubility prediction and optimize enzyme design. By combining graph neural networks with powerful tools like AlphaFold2 and Rosetta, SolvIT helps researchers prioritize high-solubility candidates and create well-expressed enzymes efficiently. 💡 𝗞𝗲𝘆 𝗙𝗲𝗮𝘁𝘂𝗿𝗲𝘀: AI-Powered Solubility Predictions: Predict solubility with precision using our GNN-based model. Seamless Automation: Automate feature extraction, prediction, and result formatting with Snakemake. Open Source: Free for the scientific community to enhance and innovate further. 📂 𝗚𝗲𝘁 𝗦𝘁𝗮𝗿𝘁𝗲𝗱 Explore the code and documentation here: GitHub Repository Dive into the science behind it in our PNAS publication: DOI: 10.1073/pnas.2313809121 🔗 𝗪𝗵𝘆 𝗧𝗵𝗶𝘀 𝗠𝗮𝘁𝘁𝗲𝗿𝘀: Protein design is one of the most exciting frontiers in computational biology. Tools like SolvIT simplify the path to designing enzymes that are thermally stable, highly active, and expressible, unlocking new possibilities in industrial and therapeutic applications. This is just the beginning. We are excited to see how the community uses SolvIT to push the boundaries of protein engineering! Let’s solve it together with SolvIT. 💡✨ Link to the repository: https://lnkd.in/dA62-Dmk

Our team at Enzymit is thrilled to join the newest cohort of Israel’s Innovation Dream Team and celebrate the opening of the Innovation Expo by The Peres Center for Peace and Innovation! Innovation in the space of bioproduction and sustainability is deeply aligned with the vision of Shimon Peres, the namesake of the Peres Center for Peace and Innovation. He believed in harnessing cutting-edge science and technology to create a better, more sustainable world, a belief that continues to inspire us today. At Enzymit, we share this vision. We believe in a future where manufacturing is reimagined through bioproduction. By leveraging the power of biology and AI, we develop sustainable solutions that reduce waste, conserve resources, and transform industries. This is more than innovation; it’s about reshaping how we create materials, food, and medicine to meet the needs of our planet and its people. Through our work in enzyme design and process engineering, we aim to honor this legacy by delivering solutions that inspire progress, foster global connections, and lay the foundation for a more sustainable and equitable future. Israel Innovation Authority רשות החדשנות Ministry of Economy and Industry-משרד הכלכלה והתעשייה Gideon Lapidoth The Peres Center for Peace and Innovation

Thrilled to share the incredible progress our science team has made in optimizing enzymes for our 𝗛𝘆𝗮𝗹𝘂𝗿𝗼𝗻𝗶𝗰 𝗔𝗰𝗶𝗱 𝗰𝗲𝗹𝗹-𝗳𝗿𝗲𝗲 𝗯𝗶𝗼𝗽𝗿𝗼𝗱𝘂𝗰𝘁𝗶𝗼𝗻 𝗽𝗿𝗼𝗰𝗲𝘀𝘀! With a 𝘀𝗶𝗻𝗴𝗹𝗲-𝘀𝗵𝗼𝘁 𝗱𝗲𝘀𝗶𝗴𝗻 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵 -meaning NO high-throughput screening and only with only a handful of designs - we’ve achieved remarkable improvements in thermal stability (Tm) with Tm boosts of 𝗺𝗼𝗿𝗲 𝘁𝗵𝗮𝗻 𝟮𝟬°𝗖 in some cases. With an incredible 𝟮𝟬% 𝗼𝗳 𝗲𝗮𝗰𝗵 𝗲𝗻𝘇𝘆𝗺𝗲’𝘀 𝗮𝗺𝗶𝗻𝗼 𝗮𝗰𝗶𝗱 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗲 𝗺𝘂𝘁𝗮𝘁𝗲𝗱 in order to reach our stability targets. We were not only successful in improving Tm but also 𝗿𝗲𝘀𝗰𝘂𝗶𝗻𝗴 𝗲𝗻𝘇𝘆𝗺𝗲𝘀 𝘄𝗶𝘁𝗵 𝗯𝗮𝗿𝗲𝗹𝘆 𝗱𝗲𝘁𝗲𝗰𝘁𝗮𝗯𝗹𝗲 𝗲𝘅𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 (which previously didn’t even allow for a Tm measurement) and pushing their Tm above 70°C. This is a game-changer for their usability in bioproduction! 𝗪𝗵𝘆 𝗶𝘀 𝗲𝗻𝘇𝘆𝗺𝗲 𝗧𝗺 𝗶𝗺𝗽𝗼𝗿𝘁𝗮𝗻𝘁? Enzyme Tm is directly tied to enzyme stability and determines how many cycles an enzyme can complete before losing activity. In simpler terms, the more stable an enzyme, the more cycles it can catalyze before “wearing out.” In a production setting, this stability has a direct impact on 𝗲𝗰𝗼𝗻𝗼𝗺𝗶𝗰 𝗳𝗲𝗮𝘀𝗶𝗯𝗶𝗹𝗶𝘁𝘆: - 𝗠𝗼𝗿𝗲 𝗖𝘆𝗰𝗹𝗲𝘀, 𝗟𝗼𝘄𝗲𝗿 𝗖𝗼𝘀𝘁: A longer enzyme lifespan means fewer enzymes are needed to produce the same output. This reduction in enzyme consumption leads to significant cost savings. - 𝗦𝗰𝗮𝗹𝗮𝗯𝗶𝗹𝗶𝘁𝘆 𝗮𝗻𝗱 𝗘𝗳𝗳𝗶𝗰𝗶𝗲𝗻𝗰𝘆: Enzymes that can handle higher temperatures and longer reaction times make the entire process more robust and scalable, essential for industrial applications where efficiency is key. In the context of 𝗛𝘆𝗮𝗹𝘂𝗿𝗼𝗻𝗶𝗰 𝗔𝗰𝗶𝗱 𝗽𝗿𝗼𝗱𝘂𝗰𝘁𝗶𝗼𝗻, these Tm improvements allow us to produce more with less resources, advancing us towards our vision where sustainable bio-production is not only green but is cost effective Proud to have such a talented and innovative team, redefining the boundaries of enzyme engineering and biotechnology. Here’s to making bio production more affordable and sustainable!

We're #hiring a new Laboratory Technician in Ness Ziona! Apply today or share this post with your friends and colleagues!