GENOSKIN

Human immune responses begin at the skin. Are you capturing the full picture in your infectious disease research? Developing therapeutics for infectious diseases means more than targeting the pathogen—you also need to understand how your treatment interacts with the immune system at the injection site. To capture these dynamics in a human-relevant way, researchers are turning to HypoSkin®, a model designed to mimic real skin immune responses ex vivo. Use HypoSkin® for multiple assessments, including: 🔬 Investigate early host–pathogen interactions 💉 Test vaccines, monoclonal antibodies, or anti-infectives via intradermal or subcutaneous injection 🧬 Profile immune activation using tools like RNA-seq and multiplex protein detection ⚠️ Assess local toxicity or reactogenicity before the clinical stage 🧴 Explore the efficacy of topical antivirals or antimicrobials Because HypoSkin® retains viable immune cells—like Langerhans cells, dendritic cells, mast cells, and tissue-resident memory T cells—you get access to a more complete picture of how your therapeutic interacts with human immune tissue. ➡️ Looking to generate more relevant preclinical data? We’re here to help: https://bit.ly/3Em7yKJ #InfectiousDisease #Immunology #HumanSkinModel #DrugDevelopment

🧴🦟 Combined Use of Sunscreen and Insect Repellent Reduces UV Protection: New Research Alert! A new study led by CNRS researchers has uncovered that using insect repellent and sunscreen together may significantly reduce UV protection—a finding with important implications for public health and product safety. To reach these conclusions, the researchers used Genoskin’s NativeSkin® models, which offer real human skin maintained ex vivo, to accurately assess how these products interact when applied simultaneously. The results showed that certain combinations decrease the effectiveness of sunscreen, raising concerns about the safe use of these common products. This groundbreaking research not only highlights the potential risks of combined application but also underscores the importance of realistic testing environments to better understand product interactions on human skin. 🔗 Read the full CNRS press release for more details: https://bit.ly/42B2f3d

Are you confident in your understanding of immune responses to your biologic? Immunogenicity is a double-edged sword—some immune responses are desired, while others can lead to safety concerns and reduced efficacy. Relying on traditional models can result in unforeseen risks in clinical trials. That’s where ex vivo human skin models come in. With HypoSkin®, you can assess both expected and unwanted immune reactions early and in a human-relevant environment—bridging the gap between preclinical testing and real-world outcomes. 🔎 Learn how this innovation could redefining immunotoxicity testing in our latest blog post: https://lnkd.in/eRzX39aH 💬 What are your biggest challenges in predicting immune responses? Let’s discuss in the comments! 👇 #Biotech #ImmunogenicityTesting #Toxicology #ExVivoModels #HumanData #PharmaInnovation

What if your next breakthrough in medical device development didn’t come from a lab rat—but from real human skin? The way we design and test medical devices is changing—and fast. Traditional models can’t keep up with the complexity of today’s wearables, patches, and advanced wound care solutions. 💡 In our latest blog, we explore how HypoSkin® can accelerate medical device development while reducing the need for animal testing. What you’ll learn: 📌 The hidden cost of traditional testing models—and why medical device testing needs to evolve 📌 How ex vivo human skin models mimic real-life skin responses 📌 What makes HypoSkin® ideal for local toxicity & immune response testing 📌 How to integrate this model into your device development workflow Read the full article: https://bit.ly/44njbvk #MedicalDevices #NonClinicalTesting#HumanSkinModel

🔬 The Naked Immunology Series Continues: Watch the Webinar on the NLRP1 Inflammasome! The ninth session of our Naked Immunology webinar series is available on demand! This time, we had the privilege of hosting Dr. Etienne Meunier, who provided an in-depth look at the NLRP1 inflammasome—a key player in innate immunity with implications for infection, inflammation, and beyond. If you missed it live, don’t worry! You can now access the full replay and dive into the latest insights on inflammasome biology. 🎥 Watch the replay here: https://bit.ly/3Yh7Yc0 #Immunology #Inflammasome #HumanSkinBiology #ScientificWebinar

🌿 Sustainable Innovation for Skin Health: PDRNs from Microalgae Exciting news from the scientific community! Researchers from AmorePacific have demonstrated that polydeoxyribonucleotides (PDRNs) derived from the microalga Chlorella protothecoides show significant potential as a sustainable and effective ingredient for cosmetic and clinical applications focused on skin health and wound healing. By leveraging Genoskin’s WoundSkin® model, the team was able to assess the efficacy of these PDRNs in promoting cell proliferation, migration, collagen synthesis, and angiogenesis. The results are promising: PDRNs not only enhanced wound closure in human skin models but also stimulated key growth factors and signaling pathways related to skin regeneration and tissue repair. These findings highlight how eco-friendly, microalgal-derived ingredients can deliver robust regenerative effects while also supporting sustainable and ethical production practices. 🔗 Read the full study to discover more about this innovative approach: https://bit.ly/3E5GbV1

🔎 Can human skin models enhance ADME testing? Traditional models like animal studies and 2D cell cultures often lack the ability to accurately predict how drugs behave in human skin. That’s where HypoSkin® comes in. Why choose HypoSkin for ADME testing? ✅ Real Human Relevance: Uses biostabilized human skin to capture human-specific responses. ✅ Complex Drug Metabolism: Preserves metabolic enzymes and immune cells to study drug processing. ✅ Absorption & Distribution: Tracks how compounds penetrate and distribute within the skin. ✅ Elimination & Retention: Monitors compound persistence for better safety and efficacy data. ✅ Reliable Data: Generates more predictive and translatable insights to guide your development process. Interested in how HypoSkin® can transform your ADME testing strategy? 👉 Let’s connect and discuss your needs!

Studying wound infections has long relied on animal models, but the human skin response to infection can differ significantly. That’s where WoundSkin® comes in—our ex vivo human skin model that offers a more relevant, more predictive approach to understanding wound healing and infections. ✅ Human relevance – Because WoundSkin is real human skin, it provides direct transferability of data interpretation, overcoming species differences seen with animal models. ✅ Comprehensive wound healing processes – The model recapitulates key aspects of wound repair, including epithelial tongue formation, crust development, and bacterial biofilm formation. ✅ Infection modeling – Researchers can introduce specific bacterial strains onto the wound to study infection progression in a controlled, reproducible manner. ✅ Inflammatory responses – By analyzing pro-inflammatory cytokine expression, WoundSkin allows researchers to track how the immune system responds to bacterial infections in human skin. With its human specificity and robust infection modeling capabilities, WoundSkin is transforming the way researchers study wound healing, infection dynamics, and potential therapeutic interventions. Curious to learn how WoundSkin can support your research? Visit our website: https://lnkd.in/ekE-ZE4t

Missed our latest webinar? Catch the replay! 🎥 We had an incredible session with Dr. Julien Nicolas, who presented an innovative strategiy to improve subcutaneous administration of vesicant and irritant anticancer drugs with water-soluble polymer prodrugs using a custom linker. 💉 If you’re working in oncology research, this replay is a must-watch! However the technique is applicable to a broad range of compounds, from small molecules to mRNA. Discover how this cutting-edge approach can: ✔️ Improve drug targeting to the right site ✔️ Ensure sustained drug release ✔️ Maintain therapeutic efficacy while minimizing local toxicity ✔️ Enhance safety with degradable polymer backbones Overall, the approach is intended to improve patient comfort by switching from IV to subcutaneous administration. 💡 Don’t miss out on the opportunity to learn from novel research that could change the way we deliver anticancer treatments. Watch the replay here: https://lnkd.in/ehDiMBtd #Oncology #DrugDelivery #CancerResearch #SubcutaneousAdministration #WebinarReplay

💡 Unlock the Power of Real Human Skin for Your Cosmetic Innovations! Ever wondered how your formulations interact with real human skin? With NativeSkin®, you can bridge the gap between lab results and real-world performance. Our latest application note dives into how this patented ex vivo model helps you assess efficacy, safety, skin absorption, metabolism, and more—without the need for animal testing. 🧴 What is waiting for you inside? ✔️Key features of human skin model designed to support a wide range of cosmetic assessments ✔️ Comprehensive insights into skin responses ✔️ Real examples of how NativeSkin can provide reliable data to enhance your product development Get the insights you need to take your formulations to the next level! 👉 Download the application note now and see how NativeSkin can enhance your research: https://lnkd.in/ejdzrwwn #Cosmetics #Skincare #NonAnimalTesting #Innovation