Pharmaron

This study undertaken by Aker BioMarine ASA and Pharmaron investigates the systemic kinetics of EPA and DHA in male rats, administered as triglycerides (TAG), phosphatidylcholine (PC), or lysophosphatidylcholine (LPC). The research involved tracking radiolabelled EPA and DHA in plasma, whole blood, and cumulative radioactivity in expired air, faeces, and urine over time. The findings revealed first-order radiotracer kinetics for both fatty acids, with notable differences in maximum concentration (Cmax) and time to maximum concentration (Tmax) between TAG and PC. LPC exhibited significant differences in area under the curve (AUC), Cmax, Tmax, and total clearance compared to TAG and PC.   Access the publication here: https://lnkd.in/gSCfNM5v

Get ready for AACR 2025! Join us to explore groundbreaking advancements in cancer drug discovery. Our posters will showcase innovative studies and cutting-edge solutions. Find us at our posters: > PharmaRonNet: Integrating multi-omics data to reveal the key biological pathways When: 4/28/25, Session: 9am – 12pm Location: Poster Section 47, Board Number: 19 > Identification of potential therapeutic targets by in vivo CRISPR technology When: 4/29/25, Session: 2pm – 5pm Location: Poster Section 22, Board Number: 18 > ADC efficacy and safety evaluation based on organoid models When: 4/29/25, Session: 2pm – 5pm Location: Poster Section 4, Board: 21 Connect directly with our scientists to discuss your latest research projects and find out how we can support you. The following team members will attend: Scientists: Jingqi Huang, Tan Pang, Fang He, Pengfei Gao, Yuhui Wang, Kaiqiang Wu Business Development Managers: Lorraine Liu, Stephen Edgcomb, Allison Olszewski Schedule a meeting with us today at https://lnkd.in/dWV8AAJ3 #AACR25 #CancerResearch #DrugDiscovery #PreclinicalResearch #Pharmaron #Oncology

Pharmaron’s Cell Line Development Services offer a comprehensive approach, from plasmid construction to final clone selection, ensuring efficiency and accuracy at every step. With advanced screening methods and high-throughput systems like Solentim VIPS, we identify and optimize top-performing biologic candidates, supporting their transition from development to production. Our tailored processes use trusted cell lines like CHO-K1 and ensure reliability, high expression levels, and scale-up success. Connect with us to learn how we can optimize your biologics program: https://lnkd.in/d59tAzKW #CellLineDevelopment #Biologics #DrugDevelopment #Biopharma #PrecisionBiologics #CDMO

Join us TOMORROW for Pharmaron's exclusive webinar: "What’s New with the ICH M12 Guidance on Drug-Drug Interactions?" 🗓️ Date: 10th April 2025 ⏰ Time: 9 AM ET / 2 PM GMT 🎙️ Moderator: Chris Bode Pharmaron's experts will be diving into the latest updates on the M12 guidance - you won’t want to miss their insights. With Chris Bode moderating, it’s sure to be an engaging and informative session. 📅 Mark your calendar and register here: https://lnkd.in/gnF442Jj #PharmaronWebinar #ICHguidance #DrugDrugInteractions #PharmaceuticalIndustry #PharmaInnovation #Webinar #RegulatoryScience

We use cell painting, subsequent data analysis, and machine learning for various applications to make this sensitive and powerful method available to our clients. Cell painting enables •Phenotypic drug discovery •Target deconvolution •Analysis of signaling pathways and mechanism of action •Investigating drug resistance mechanisms The cells are screened via the high-content imaging system Operetta, and our adept bioinformaticians conduct comprehensive data analysis utilizing machine learning algorithms. Our fully automated, high-throughput assay and screening process is finely tuned to expedite cell painting applications with precision. To learn more about this fascinating technique and how we can support your drug discovery projects, please visit https://lnkd.in/dtaQnv_P for more details and download our case study showing a profiling study with 390 kinase inhibitors. #drugdiscovery #cellpainting #machinelearning #highthroughputscreening #bioinformatics #morphologicalprofiling 

Following the success of our first Integrated Drug Discovery webinar, we’re thrilled to announce the next webinar in our series: ➡️ 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 𝐚𝐧𝐝 𝐎𝐩𝐭𝐢𝐦𝐢𝐬𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐌𝐨𝐥𝐞𝐜𝐮𝐥𝐚𝐫 𝐆𝐥𝐮𝐞𝐬: 𝐂𝐨𝐧𝐜𝐞𝐩𝐭𝐬 𝐚𝐧𝐝 𝐂𝐚𝐬𝐞 𝐒𝐭𝐮𝐝𝐢𝐞𝐬 📅 𝐉𝐮𝐧𝐞 𝟏𝟖𝐭𝐡 | 𝟒𝐩𝐦 𝐔𝐊 / 𝟏𝟏𝐚𝐦 𝐄𝐓 Join Pharmaron and leading experts in drug discovery for a deep dive into the emerging field of molecular glues—small molecules that induce or stabilize protein–protein interactions (PPIs) to achieve targeted protein degradation or modulation. This insightful session will explore the history, mechanisms, and translational potential of molecular glue degraders, with real-world case studies that highlight innovative approaches to hit identification and characterization. Whether you're in early-stage research or advancing a pipeline, this webinar is packed with inspiration and actionable knowledge. ➡️ Register now: https://lnkd.in/dF-b8KXr #Pharmaron #DrugDiscovery #MolecularGlues #ProteinDegradation

We are proud to have contributed to the ground-breaking total synthesis of enlicitide, an investigational orally bioavailable PCSK9 inhibitor, that was recently published by MSD in J. Am. Chem. Soc. Congratulations to all our collaborators on this remarkable achievement of delivering for the patients through great science and execution! https://lnkd.in/dPJWsHKE #pharmaron #peptides #macrocyclicpeptides

On this World Health Day, we recognize the essential connection between health, science, and innovation. At Pharmaron, we are proud to support our partners in the life sciences community who are dedicated to developing treatments that improve and extend lives worldwide. Our mission is deeply rooted in advancing human health. From early discovery through to clinical development and manufacturing, our teams are committed to delivering high-quality scientific services that enable life-changing breakthroughs. As we reflect on the significance of this day, we celebrate the scientists, researchers, and healthcare professionals who make health possible for all. Learn more about how Pharmaron supports global health innovation: 🔗 https://lnkd.in/dWTP-FWC #WorldHealthDay #Pharmaron #GlobalHealth #LifeSciences #ScientificInnovation

Next week, Anna Witkowska will be attending the 𝐃𝐌𝐃𝐆 𝐓𝐚𝐫𝐠𝐞𝐭𝐞𝐝 𝐂𝐨𝐯𝐚𝐥𝐞𝐧𝐭 𝐈𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫𝐬 𝐌𝐞𝐞𝐭𝐢𝐧𝐠, diving into the latest advancements in 𝐓𝐂𝐈 𝐝𝐫𝐮𝐠 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲, 𝐏𝐊/𝐏𝐃 strategies, and 𝐬𝐚𝐟𝐞𝐭𝐲 𝐜𝐨𝐧𝐬𝐢𝐝𝐞𝐫𝐚𝐭𝐢𝐨𝐧𝐬. With the potential to unlock 'undruggable' targets like KRAS G12C, TCIs are reshaping modern drug development - but not without challenges! Looking forward to insightful conversations on new warheads, drug disposition, and optimization strategies. If you're attending, be sure to connect! #Pharmaron #DrugDiscovery #CovalentInhibitors #Pharma #PKPD

Pharmaron is headed to AACR 2025 in Chicago! Join us April 26-30 to explore how our in vitro biology and in vivo pharmacology capabilities accelerate drug discovery. Let’s connect! Schedule a meeting with our scientific leaders to discuss your projects and stop by our posters to see our latest research. •Poster: PharmaRonNet: Integrating multi-omics data to reveal the key biological pathways •Poster: Identification of potential therapeutic targets by in vivo CRISPR technology •Poster: ADC efficacy and safety evaluation based on organoid models Find all details here: https://lnkd.in/dbaaENMy #AACR25 #CancerResearch #DrugDiscovery #PreclinicalResearch #Pharmaron #Oncology