Ardena

In the latest issue of the International Pharmaceutical Industry Journal (IPI), our colleague Dirk-Jan van Zoelen, Head of Drug Substance at Ardena's site in Oss, Netherlands, explores the role of innovation in small molecule API manufacturing. Using the 6M methodology as a framework—Manpower, Method, Machine, Material, Measurement, and Mother Nature—Dirk-Jan highlights how emerging technologies and innovative approaches, from AI-driven analytics to greener synthesis routes, are transforming API manufacturing. The article underscores Ardena’s commitment to scientific rigor and innovation as we support our partners in bringing better medicines to patients, faster. Read the full article below or find it online here: https://lnkd.in/dktVPUda #Ardena #DrugSubstance #APIdevelopment #Innovation #PharmaceuticalManufacturing #CDMO #IPI #FlowChemistry #Sustainability #SmallMolecules

Greetings from the #WRIB Conference in New Orleans! The Ardena bioanalytical team is all set at Booth #10 — ready to connect, exchange ideas, and dive into the science. If you're attending, stop by to meet the team and learn more about our work in regulated analysis, biomarkers, oligonucleotides, ADCs and more. Let’s talk bioanalysis! #WRIB2025 #Bioanalysis #Biomarkers #ADC #GeneTherapies #Oligonucleotides #Ardena

With solubility remaining a key hurdle in drug formulation, a recent Drug Development & Delivery feature explores how #NovelExcipients are shaping new strategies—highlighting Ardena’s parenteral formulation expertise among other industry insights. Our colleagues Oluwatomide Adeoye and Timothy Pas share insights into the evolving role of #cyclodextrins —particularly 2-(Hydroxypropyl)-Beta-Cyclodextrin (HP-β-CD)—and the formulation considerations required when working with such excipients in #injectable drug products. Read the full article here: https://lnkd.in/ezGAY5nJ #FormulationDevelopment #Parenterals #Solubility #Bioavailability #DrugDevelopment #CDMO #PharmaScience #InjectableFormulations #Ardena #Experts

The 19th Annual WRIB Conference kicks off today in New Orleans! The Ardena team is on site and ready to welcome you at Booth #10. We’re looking forward to sharing our latest bioanalytical case studies and discussing how we support drug development across: 🔹 Regulated analysis 🔹 Assay strategies 🔹 ADCs 🔹 Oligonucleotides 🔹 Gene therapies 🔹 Biomarkers Meet our experts: Martha M. – Senior Director, Business Development & Bioanalytical Lead Amber Basinger – Director, Business Development Niels Nijstad – Technical Business Developer, Bioanalysis #FokaVenema – Senior Scientist, Project Manager & Study Director, Bioanalysis #MarkBoterman – Director, Laboratory Bioanalysis 📍 Stop by Booth #10 — we’re here all week! #WRIB2025 #Bioanalysis #ADC #GeneTherapies #Biomarkers #Ardena

We’re pleased to share that Hibreniguss (Hibre) Terefe, Ph.D., Director of Product Development at Ardena’s recently acquired site in Somerset, NJ, has authored an article in Drug Development & Delivery exploring strategies to enhance bioavailability and solubility in oral solid dosage forms. Drawing on practical experience, dives into the growing role of hot melt extrusion (#HME) in addressing solubility challenges. He discusses how HME improves the dissolution rate and stability of poorly soluble compounds, while also offering excellent scalability, making it a valuable tool for both early-phase development and larger-scale manufacturing. A valuable read for those navigating the complexities of oral solid dosage formulation. Read the full article: https://lnkd.in/dVy-Wt52 #Ardena #OralDrugDelivery #FormulationDevelopment #Bioavailability #HotMeltExtrusion #PharmaInnovation #DrugDevelopment

We’re looking forward to the 4th Annual LNP Formulation & Process Development Summit, taking place in Boston on April 15–16. As specialists in #Nanomedicine development and manufacturing, Ardena supports complex formulations from early feasibility #FillAndFinish for clinical supply, including #LNPs and other precision delivery systems. Whether you're working with mRNA, siRNA, DNA, or other nucleic acid-based payloads, we help navigate your path from concept to clinic with tailored, phase-appropriate solutions. Meet us at #Booth29 to explore how we can support your LNP programs. Our attending team includes: 🔸 Mark van Eldijk, PhD – Business Unit Director, Nanomedicines 🔸 Aditya Kulkarni, PhD – Director, Business Development 🔸 Amber Basinger – Director, Business Development Let’s connect in Boston! #Ardena #LNPDevelopment #mRNA #DrugDevelopment #CDMO #BiotechEvents

Ardena is heading to the 19th Annual #WRIB Conference in New Orleans, April 7-11! Join us at Booth #10 to discuss how our bioanalytical expertise can support your drug development programs. Our team will be available to explore key topics, including #RegulatedBioanalysis, #ADCStrategies, #BiomarkerAssays, and #OligonucleotideAnalytics. Meet our experts at WRIB: 🔸Martha M. – Senior Director, Business Development & Bioanalytical Lead 🔸Amber Basinger – Director, Business Development 🔸Niels Nijstad – Technical Business Developer, Bioanalysis 🔸Foka Venema – Senior Scientist, Project Manager & Study Director, Bioanalysis 🔸Mark Boterman – Bioanalytical Laboratory Director Let’s discuss your project needs and explore how Ardena can help advance your bioanalytical strategies. Contact us to schedule a meeting at: See you in New Orleans! #WRIB2025 #Bioanalysis #Pharmacokinetics #Biomarkers #ADC #Oligonucleotides #Ardena

𝗝𝗼𝗶𝗻 𝘂𝘀 𝗳𝗼𝗿 𝗮 𝗹𝗶𝘃𝗲 𝘀𝗲𝗺𝗶𝗻𝗮𝗿 𝗼𝗻 𝗼𝗽𝘁𝗶𝗺𝗶𝘇𝗶𝗻𝗴 𝘀𝗺𝗮𝗹𝗹 𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗲 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁 𝗮𝗻𝗱 𝗯𝗶𝗼𝗮𝘃𝗮𝗶𝗹𝗮𝗯𝗶𝗹𝗶𝘁𝘆 𝗲𝗻𝗵𝗮𝗻𝗰𝗲𝗺𝗲𝗻𝘁! 📅 April 24, 2025 | 🕚 11 AM - 3 PM EDT | 📍 Life Sciences Pennsylvania, King of Prussia, PA From early-stage development to formulation and manufacturing, bringing a small molecule to market comes with critical challenges. This seminar will explore key strategies for enhancing clinical success and leveraging Hot Melt Extrusion (HME) to improve solubility and bioavailability. Speakers: Hibreniguss (Hibre) Terefe, Ph.D. – Ardena Samuel Chuang, PhD – Charles River Laboratories Agenda Highlights: 🔸Strategic #SmallMolecule development – from candidate selection to IND strategies 🔸#HotMeltExtrusion – a powerful approach to solubility and stability challenges 🔸Q&A and #Networking – engage with experts and industry peers 🎟 Seats are limited – register now! 🔗 #Register here: https://lnkd.in/dxjkZxcd #PharmaceuticalDevelopment #DrugFormulation #Bioavailability #HME #SmallMolecules #PharmaScience #LiveSeminar

Join us for an exclusive #webinar on Hot Melt Extrusion for poorly soluble drugs! 📅 May 20 | ⏰ 5PM CET | 11AM ET Poor solubility remains one of the biggest challenges in drug development. Hot Melt Extrusion (#HME) has emerged as a leading solution, enabling the creation of #AmorphousSolidDispersions (ASDs) that enhance bioavailability and dissolution rates. 🔗 #RegisterNow: https://lnkd.in/dzNTb8ih What you’ll learn: ✅ Strategies for optimizing HME formulations for solubility enhancement ✅ Excipient selection and drug-polymer compatibility for stable ASDs ✅ Process development and scale-up considerations for production ✅ Real-world case studies demonstrating HME success Meet the experts: 🔹Hibreniguss (Hibre) Terefe, Ph.D. – Director, Product Development, Ardena 🔹Shahab Kashani Rahimi, PhD – Lead Principal Scientist, Product Development, Ardena Designed for pharmaceutical scientists, formulation specialists, R&D professionals, and biotech leaders, this session will provide practical insights into leveraging HME for successful drug development. Learn more at https://lnkd.in/dcCrg2GJ #Ardena #HotMeltExtrusion #Bioavailability #PharmaceuticalFormulation #DrugDevelopment

In a recent article published by The Medicine Maker, our experts Hibreniguss (Hibre) Terefe, Ph.D. and Shahab Kashani Rahimi, PhD explore the myths and realities of #HotMeltExtrusion (HME) and its critical role in oral dosage form development. They address common misconceptions surrounding the technology and explain how HME can be a transformative approach for enhancing bioavailability in drug formulations, especially when combined with other advanced technologies. HME, a key capability at our recently acquired site in Somerset, NJ, adds to Ardena's already extensive expertise in #SprayDrying and other bioavailability enhancement technologies, strengthening our ability to support complex drug formulations. Read the full article here: https://lnkd.in/dYAAB68m #Ardena #TwinScrewExtrusion #HME #Bioavailability #DrugDevelopment #Expertise